DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11399 and Pcif1

DIOPT Version :9

Sequence 1:	NP_649254.2	Gene:	CG11399 / 40295	FlyBaseID:	FBgn0037021	Length:	920	Species:	Drosophila melanogaster
Sequence 2:	NP_001361055.1	Gene:	Pcif1 / 228866	MGIID:	2443858	Length:	723	Species:	Mus musculus

Alignment Length:	753	Identity:	318/753 - (42%)
Similarity:	449/753 - (59%)	Gaps:	93/753 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 ASASNNMSPSPTAGAPTVTGPILPDNLGVGAGSSPVASCSSPSTPTKTHAPSPLESMGHTPQGPP 124
            |..:|....||..||     .:|..:.|..:.|.|   ||          |.|:..:
Mouse    16 AEMANENHGSPREGA-----SLLSHSPGTSSQSQP---CS----------PKPVRLV-------- 54

  Fly   125 TLGPGGYGEELTAELVNQGWRKFWSKRENRPYYWNKVTGESLWEMPGTRPFDPLTDPLGICHAGG 189
                    ::|..|||:.||.|.||:||:||||:|:.|.:||||||.....|.|:||||:.....
Mouse    55 --------QDLPEELVHAGWEKCWSRRESRPYYFNRFTNQSLWEMPVLGQHDVLSDPLGLNATPL 111

  Fly   190 P-------TPIIPNMHQQQQHQHHHLK----RRPSDDMHIHPNQHHMGGGPPM------------ 231
            |       ||.:.|..:::|.......    ::|..::.:.|....:...|.:
Mouse   112 PQDSSLVETPPVENKSRKRQLSEEQPSGNGVKKPKIEIPVTPTSQSVPSSPSIPGTPTLKIWGSS 176

  Fly   232 ---KKFVLAGP----WDLEVCTNAVIVERPPTLLPQPHPEVEALRAAFTMKLLKTYEDLCMRREN 289
               |:..|..|    |||::.|||||..|.|:.:..|||:||.||:...:||.:.|.:||.:||.
Mouse   177 TEDKQAALLRPTEVYWDLDIQTNAVIKHRGPSEVLPPHPDVELLRSQLILKLRQHYRELCQQREG 241

  Fly   290 IKAPRDSFNRWLMERKVIDTGCDPLLPSSCMPEISSSMYREIMSDIPIKIVKPKFTGDARKQLSR 354
            |:.||:|||||::||||:|.||||||||:|.|.:|.||:||||:||||::.:.||..:|::.|.:
Mouse   242 IEPPRESFNRWMLERKVVDKGCDPLLPSNCEPVVSPSMFREIMNDIPIRLSRIKFREEAKRLLFK 306

  Fly   355 YAEAAKQIIESRSAPAESKKVVKWNVEDTFQWLRRTVGASYEDFQDRLAHLKRQCEPHLVETVKS 419
            |||||:::||||||..:|:|||||||||||.|||:...||.||:.|||.||:|||.||:....|.
Mouse   307 YAEAARRLIESRSASPDSRKVVKWNVEDTFSWLRKEHSASKEDYMDRLEHLRRQCGPHVSAAAKD 371

  Fly   420 SVETLCVKIYHLSADHARKIRERHSQLLKEHGIPEPTPPPP-PPHLKKVWCYPIQFAVPSPRMPT 483
            |||.:|.||||:|.::.::|||:|..:|||:.|||...... .|.|  |:|||::.||.:|.||:
Mouse   372 SVEGICSKIYHISLEYVKRIREKHLAVLKENNIPEEVEASELEPRL--VYCYPVRLAVSAPPMPS 434

  Fly   484 IEYLQDRDHMIIKYTPATINQPDAQYINLTYLQKLEQLYRHNCFDDKKFDLFIGRVWCLLKRYQT 548
            :|...:...:.|:|....:.      ::.:|..||..|||::|.||..|:.|:.||||||:|||.
Mouse   435 VEMHVENSVVCIRYKGEMVK------VSRSYFSKLWLLYRYSCVDDSAFERFLPRVWCLLRRYQM 493

  Fly   549 FLGNALNSSQEAELTQAALPVPVFECLHRQFGVSFECFASPFNSYFRQYCSAFADTDAYFGSRGP 613
            ..|..|   .|....|.:|||.|||.|||.|||||||||||.|.|||||||||.|||.|||||||
Mouse   494 MFGVGL---YEGTGLQGSLPVHVFETLHRLFGVSFECFASPLNCYFRQYCSAFPDTDGYFGSRGP 555

  Fly   614 FLDFKPVSGSFQVNPPHCEELIEASLLHIDKLLTDTMEPLSFIVFLPEWK-----SISKLDDSMY 673
            .|||.|:||||:.|||.||||::|.:.|.:|||..:.||||||||:|||:     ::::::.|.:
Mouse   556 CLDFTPLSGSFEANPPFCEELMDAMVSHFEKLLESSAEPLSFIVFIPEWREPPTPALTRMEQSRF 620

  Fly   674 KRRSMVVLGMAHEYRHGYQHMLQKSDVLIKCMQGTQVVWLQNSAGYARWGPNEIRVEALREAFRP 738
            ||..:|:....||||.|.||:.:|.::..|.:..|.|::|||..|:|:|||...|::.|..|:
Mouse   621 KRHQLVLPAFEHEYRSGSQHICKKEEMHYKAVHNTAVLFLQNGPGFAKWGPTPERLQELTAAY-- 683

  Fly   739 QRDRERERAAAAAAAAGVTSS---------QQSPSTPP 767
             :...|...:::::::..:||         :|.||..|
Mouse   684 -KQSGRSHGSSSSSSSSSSSSEAKDRDSGREQGPSREP 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11399	NP_649254.2	WW	143..170	CDD:238122	17/26 (65%)
CG11399	NP_649254.2	PCIF1_WW	524..685	CDD:289041	93/165 (56%)
Pcif1	NP_001361055.1	WW	64..94	CDD:238122	19/29 (66%)
Pcif1	NP_001361055.1	PCIF1_WW	462..632	CDD:371982	98/172 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834965
Domainoid	1	1.000	291	1.000	Domainoid score	I1533
eggNOG	1	0.900	-	-		E1_28P6D
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11134
Inparanoid	1	1.050	592	1.000	Inparanoid score	I975
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52676
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007279
OrthoInspector	1	1.000	-	-		oto93134
orthoMCL	1	0.900	-	-		OOG6_106120
Panther	1	1.100	-	-	LDO	PTHR21727
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5561
SonicParanoid	1	1.000	-	-		X5383
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790