DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pitslre and CDK11B

DIOPT Version :9

Sequence 1:	NP_649251.2	Gene:	Pitslre / 40292	FlyBaseID:	FBgn0016696	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	XP_011540792.1	Gene:	CDK11B / 984	HGNCID:	1729	Length:	804	Species:	Homo sapiens

Alignment Length:	968	Identity:	394/968 - (40%)
Similarity:	497/968 - (51%)	Gaps:	235/968 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EDGQLR----------SP--NDVHYHSRGEEDEHEGDADALYIQPP-QASRESGSGPRREKKKHS 59
            |:|:||          ||  .:.....|||||      |:|.|:|| |.||:..:..|:::|:
Human    49 EEGELRDHRMEITIRNSPYRREDSMEDRGEED------DSLAIKPPQQMSRKEKAHHRKDEKR-- 105

  Fly    60 RERRRHKERDDVGGAALALERDHRYDYRSREEHYHHHQRERSSNAAAAYAKHHLGHAYHYPQPPQ 124
            :|:|||:.....||       .|.   |.:|:...|.:|:|
Human   106 KEKRRHRSHSAEGG-------KHA---RVKEKEREHERRKR------------------------ 136

  Fly   125 QQQQPLPPAPSYAAHHYHHHQHLSGARAAPREYHSYPSGYHSGSRHGDYPMEEPTRRSSKYAESK 189
                              |.:....||   ||:..             ....|..|..|:.....
Human   137 ------------------HREEQDKAR---REWER-------------QKRREMAREHSRRERGN 167

  Fly   190 DAESLEQDLRSRLLKKRHNYVKDYETEENYEHRVERSDRREGGRKERE--RTVRSTHKQNRHDRV 252
            |...|.:|...:|.:||....|..|.::....:.||..|.|..|||||  |.|.:.|:..|.|
Human   168 DGVCLFRDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRED-- 230

  Fly   253 IELLDSPEQEHHHQHQHKSHRSKW--------REEVEVIRRKVPEDLELLARREKLLAAERESRQ 309
                          :..|...|.|        ||..|:...:.|.:            |.....|
Human   231 --------------YSDKVKASHWSRSPPRPPRERFELGDGRKPGE------------ARPAPAQ 269

  Fly   310 RKQTAREELEARRELLRERNEHSDALSPTTVAASVTAGLNIHVKRKSKPDNYEKEIKLKKRREDD 374
            :....:||....|:||.:..:.||:...|:.|.|.:|                 |.......|::
Human   270 KPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSA-----------------ESGSGSEEEEE 317

  Fly   375 IEVIRDDDDEESEESDSNEEVPEQDSEGSATESGSEDSYASKKKSKIKSKSQLEDDDEDLPLPDS 439
            .|...:::...||||:..||..|::.|    |:||....||::.::..|:.::.:|:|
Human   318 EEEEEEEEGSTSEESEEEEEEEEEEEE----ETGSNSEEASEQSAEEVSEEEMSEDEE------- 371

  Fly   440 PLSVGELYKSPKQRQRSRSVSSKSSSQSSRSSRSRSRSRSQSSLEDEVDRQDVGADASPSSSTRS 504
                         |:....:.....|:..|.|.           |.|...::|| :.:|.||..:
Human   372 -------------RENENHLLVVPESRFDRDSG-----------ESEEAEEEVG-EGTPQSSALT 411

  Fly   505 EERGMTQEQPEEKPEEKLKEKQKSLEEQIPCDDKGIPLPNYYPGVQGCRSVEEFQCLNRIEEGTY 569
             |.....:.|...|.| ||::                ||.|.|.:||||||||||||||||||||
Human   412 -EGDYVPDSPALSPIE-LKQE----------------LPKYLPALQGCRSVEEFQCLNRIEEGTY 458

  Fly   570 GVVYRAKDKRTNEIVALKRLKMEKEKEGFPITSLREINTLLKGQHPNIVTVREIVVGSNMDKIFI 634
            |||||||||:|:|||||||||||||||||||||||||||:||.||||||||||||||||||||:|
Human   459 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYI 523

  Fly   635 VMDYVEHDLKSLMETMKNRKQSFFPGEVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGIL 699
            ||:|||||||||||||   ||.|.|||||.|..||||.|.|||||||||||||||||||||.|||
Human   524 VMNYVEHDLKSLMETM---KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGIL 585

  Fly   700 KVGDFGLAREYGSPIKKYTSLVVTLWYRAPELLLCSPVYSTPIDVWSVGCIFAEFLQMLPLFPGK 764
            ||||||||||||||:|.||.:|||||||||||||.:..|||.:|:|||||||.|.|...||||||
Human   586 KVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGK 650

  Fly   765 SEIDELNRIFKELGTPNEKIWPGYTELPAVKNMLSQNSQFTEYPVSQLRKHFQEKTSEMGLSLLQ 829
            ||||::|::||:||||:|||||||:||||||.|     .|:|:|.:.|||.|....|:.|..|:.
Human   651 SEIDQINKVFKDLGTPSEKIWPGYSELPAVKKM-----TFSEHPYNNLRKRFGALLSDQGFDLMN 710

  Fly   830 GLLTYDPKQRLSADAALKHGFFKELPLPIDPSMFPTWPAKSELGARKAQASSPKPPSGGSQFKQL 894
            ..|||.|.:|:||:..|||.:|:|.||||||||||||||||| ..|..:.:||:||.||..:.||
Human   711 KFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSE-QQRVKRGTSPRPPEGGLGYSQL 774

  Fly   895 GRDEPIIVGPGNKLSSGIITGNKKSHGAGGSSASTGFVLNAGITQRQLAMGPGFSLKF 952
            |.|:                           ...|||.|.. ..|...|.||||||||
Human   775 GDDD---------------------------LKETGFHLTT-TNQGASAAGPGFSLKF 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pitslre	NP_649251.2	STKc_CDC2L1	552..851	CDD:173741	225/298 (76%)
Pitslre	NP_649251.2	PLN00009	555..854	CDD:177649	223/298 (75%)
CDK11B	XP_011540792.1	STKc_CDC2L1	441..732	CDD:173741	225/298 (76%)
CDK11B	XP_011540792.1	PLN00009	444..734	CDD:177649	223/297 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147941
Domainoid	1	1.000	434	1.000	Domainoid score	I581
eggNOG	1	0.900	-	-		E1_KOG0663
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	582	1.000	Inparanoid score	I1017
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D392617at33208
OrthoFinder	1	1.000	-	-		FOG0001516
OrthoInspector	1	1.000	-	-		otm40636
orthoMCL	1	0.900	-	-		OOG6_102464
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R970
SonicParanoid	1	1.000	-	-		X2585
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790