DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pitslre and CDK11A

DIOPT Version :9

Sequence 1:	NP_649251.2	Gene:	Pitslre / 40292	FlyBaseID:	FBgn0016696	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_001300825.1	Gene:	CDK11A / 728642	HGNCID:	1730	Length:	783	Species:	Homo sapiens

Alignment Length:	938	Identity:	373/938 - (39%)
Similarity:	484/938 - (51%)	Gaps:	213/938 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 RREKKKHSRERRRHKERDDVGGAALALE----RDHRYD-------YRSREEHYHHHQRERSSNAA 105
            ||::::...|.:|.|..||......:||    |||..:       || ||:.......|..|.|.
Human    22 RRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYR-REDSMEDRGEEDDSLAI 85

  Fly   106 AAYAKHHLGHAYHYPQPPQQQQQPLPPAPSYAAHHYHHHQHLSGARAAPREYHSYPSGYHSGSRH 170
                           :||||..
Human    86 ---------------KPPQQMS------------------------------------------- 92

  Fly   171 GDYPMEEPTRRSSKYAESKDAESLEQDLRSRLLKKRHNYVKDYETEENYEHRVERSDRREGGRKE 235
                      |..|....||.:..|        |.:|..||:.|.|....||.|:...|....::
Human    93 ----------RKEKVHHRKDEKRKE--------KWKHARVKEREHERRKRHREEQDKARREWERQ 139

  Fly   236 RERTVRSTHKQNRHDRVIELLDSPEQEHHHQHQHKSHRSKWREEVEVIRRKVPEDLELLARREKL 300
            :.|.:...|.:...||:.:|....|:|...:.|.|..    ||:.|..||
Human   140 KRREMAREHSRRERDRLEQLERKRERERKMREQQKEQ----REQKERERR--------------- 185

  Fly   301 LAAERESRQRKQTAREELEARRELLRERNEHSDALSPTTVAASVTAGLNIHVKR----------- 354
                .|.|::::.||.|:.|....:||  ::||     .|.||       |..|
Human   186 ----AEERRKEREARREVSAHHRTMRE--DYSD-----KVKAS-------HWSRSPPRPPRERFE 232

  Fly   355 --------KSKPDNYEKEIKLKKRREDDIEVIRD-DDDEESEESDSNEEVPEQDSEGSATESGSE 410
                    :::|...:|..:||:.:.::.:::.| .|..:||...|:.|....:| ||.:|...|
Human   233 LGDGRKPGEARPAPAQKPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAES-GSGSEEEEE 296

  Fly   411 DSYASKKKSKIKSKSQLEDDDEDLPLPDSPLSVGELYKSPKQRQRSRSVSSKSSSQSSRSSRSRS 475
            :....:::.....:|:.|:::|:                 ::.:.:.|.|.::|.||:...
Human   297 EEEEEEEEGSTSEESEEEEEEEE-----------------EEEEETGSNSEEASEQSAEEV---- 340

  Fly   476 RSRSQSSLEDEVDRQDVGADASPSSSTRSEERGMTQEQPEEKPEEKLKEKQKSLEEQIPCDDKGI 540
               |:..:.::.:|::.........|....:.|.::|..||..|...:....:..:.:|.....:
Human   341 ---SEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALL 402

  Fly   541 P------LPNYYPGVQGCRSVEEFQCLNRIEEGTYGVVYRAKDKRTNEIVALKRLKMEKEKEGFP 599
            |      ||.|.|.:|||||||||||||||||||||||||||||:|:||||||||||||||||||
Human   403 PIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFP 467

  Fly   600 ITSLREINTLLKGQHPNIVTVREIVVGSNMDKIFIVMDYVEHDLKSLMETMKNRKQSFFPGEVKC 664
            |||||||||:||.||||||||||||||||||||:|||:|||||||||||||   ||.|.|||||.
Human   468 ITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM---KQPFLPGEVKT 529

  Fly   665 LTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGILKVGDFGLAREYGSPIKKYTSLVVTLWYRAP 729
            |..||||.|.|||||||||||||||||||||.|||||||||||||||||:|.||.:|||.|||||
Human   530 LMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAP 594

  Fly   730 ELLLCSPVYSTPIDVWSVGCIFAEFLQMLPLFPGKSEIDELNRIFKELGTPNEKIWPGYTELPAV 794
            ||||.:..|||.:|:|||||||.|.|...|||||.||||::|::|||||||:|||||||:|||.|
Human   595 ELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVV 659

  Fly   795 KNMLSQNSQFTEYPVSQLRKHFQEKTSEMGLSLLQGLLTYDPKQRLSADAALKHGFFKELPLPID 859
            |.|     .|:|:|.:.|||.|....|:.|..|:...|||.|.:|:||:..|||.:|:|.|||||
Human   660 KKM-----TFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPID 719

  Fly   860 PSMFPTWPAKSELGARKAQASSPKPPSGGSQFKQLGRDEPIIVGPGNKLSSGIITGNKKSHGAGG 924
            |||||||||||| ..|..:.:||:||.||..:.|||.|:
Human   720 PSMFPTWPAKSE-QQRVKRGTSPRPPEGGLGYSQLGDDD-------------------------- 757

  Fly   925 SSASTGFVLNAGITQRQLAMGPGFSLKF 952
             ...|||.|.. ..|...|.||||||||
Human   758 -LKETGFHLTT-TNQGASAAGPGFSLKF 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pitslre	NP_649251.2	STKc_CDC2L1	552..851	CDD:173741	223/298 (75%)
Pitslre	NP_649251.2	PLN00009	555..854	CDD:177649	221/298 (74%)
CDK11A	NP_001300825.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..396		98/512 (19%)
		STKc_CDC2L1	420..711	CDD:173741	223/298 (75%)
		PLN00009	423..713	CDD:177649	221/297 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	721..783		34/90 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147940
Domainoid	1	1.000	434	1.000	Domainoid score	I581
eggNOG	1	0.900	-	-		E1_KOG0663
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	582	1.000	Inparanoid score	I1017
Isobase	1	0.950	-	0	Normalized mean entropy	S790
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D392617at33208
OrthoFinder	1	1.000	-	-		FOG0001516
OrthoInspector	1	1.000	-	-		otm40636
orthoMCL	1	0.900	-	-		OOG6_102464
Panther	1	1.100	-	-	O	PTHR24056
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2585
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.710