Protein Alignment Pitslre and CDK16

DIOPT Version :10

• Sequence 1: NP_649251.2
• Gene: Pitslre / 40292
• FlyBaseID: FBgn0016696
• Length: 952
• Species: Drosophila melanogaster
• Sequence 2: XP_011542222.1
• Gene: CDK16 / 5127
• HGNCID: 8749
• Length: 571
• Species: Homo sapiens
• Alignment Length: 526
• Identity: 173/526 - (32%)
• Similarity: 258/526 - (49%)
• Gaps: 74/526 - (14%)

  Fly   390 DSNEEVPEQ---DSEGSATESGSEDSYASKKKSKIKSKSQLEDDDEDLPLPDSPLSVGELYKSPK 451
            |.....|||   |..|..  .||:...|..:.:..:.:|...      ||..:|..|.|..|
Human    96 DKTNGAPEQIGLDESGGG--GGSDPGEAPTRAAPGELRSARG------PLSSAPEIVHEDLK--- 149

  Fly   452 QRQRSRSVSSKSSSQSSRSSRSRSRSRSQSSLEDEVDRQDVGADASPSSSTRSEE---RGMTQEQ 513
              ..|...|.::|:.||...:|..|.|.::....::..:|:....|..:..|..|   ..:|...
Human   150 --MGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNS 212

  Fly   514 P-EEKPEEKLKEKQKSLEEQIPCDDKGIPLPNYYPGVQGCRSVEEFQCLNRIEEGTYGVVYRAKD 577
            | .:||..: :.::.||.|                  .|...:|.:..|:::.||||..||:.|.
Human   213 PIFDKPLSR-RLRRVSLSE------------------IGFGKLETYIKLDKLGEGTYATVYKGKS 258

  Fly   578 KRTNEIVALKRLKMEKEKEGFPITSLREINTLLKGQHPNIVTVREIVVGSNMDK-IFIVMDYVEH 641
            |.|:.:||||.:::|.| ||.|.|::||::.|...:|.||||:.:|:   :.:| :.:|.:|::.
Human   259 KLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHANIVTLHDII---HTEKSLTLVFEYLDK 319

  Fly   642 DLKSLME------TMKNRKQSFFPGEVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGILK 700
            |||..::      .|.|         ||....||||.:|:.|...:||||||..|||::.:|.||
Human   320 DLKQYLDDCGNIINMHN---------VKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELK 375

  Fly   701 VGDFGLAREYGSPIKKYTSLVVTLWYRAPELLLCSPVYSTPIDVWSVGCIFAEFLQMLPLFPGKS 765
            :.||||||....|.|.|::.|||||||.|::||.|..|||.||:|.|||||.|.....|||||.:
Human   376 LADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGST 440

  Fly   766 EIDELNRIFKELGTPNEKIWPGYTELPAVKNMLSQNSQFTEYPVSQLRKHFQEKTSEMGLSLLQG 830
            ..::|:.||:.||||.|:.|||     .:.|...:...:.:|....|..|.....|: |..||..
Human   441 VEEQLHFIFRILGTPTEETWPG-----ILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTK 499

  Fly   831 LLTYDPKQRLSADAALKHGFFKEL-----PLPIDPSMFPTWPAKSELGARKAQASSPKPPSGGSQ 890
            ||.::.:.|:||:.|:||.||..|     .||...|:|.....:.:..|....:|.|...:||
Human   500 LLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSSMPDSVAGG-- 562

  Fly   891 FKQLGR 896
              |.||
Human   563 --QHGR 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pitslre	NP_649251.2	STKc_CDC2L1	552..851	CDD:173741	122/305 (40%)
CDK16	XP_011542222.1	STKc_PCTAIRE1	236..532	CDD:270854	126/314 (40%)