DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pitslre and Eip63E

DIOPT Version :9

Sequence 1:	NP_649251.2	Gene:	Pitslre / 40292	FlyBaseID:	FBgn0016696	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_001261373.1	Gene:	Eip63E / 38433	FlyBaseID:	FBgn0005640	Length:	538	Species:	Drosophila melanogaster

Alignment Length:	561	Identity:	169/561 - (30%)
Similarity:	261/561 - (46%)	Gaps:	87/561 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   335 LSPTTVAASVTAGLNIH---VKRKSKPDNYEKEIKLKKRREDD---IEVIRDDDDEESEESDSNE 393
            ::.||...:.|...|..   ..|:.|....:   |||||....   :.:.|:|.||.:.....:.
  Fly     1 MATTTTTTTTTGATNAKDGVTMREKKGGALQ---KLKKRLSHSFGRLTISREDGDESTHHHHHHH 62

  Fly   394 EVPEQDSEGSATESGSEDSYASKKKSKIKSKSQLE--DDDEDLPLPDSPLSVGELYKSPKQRQRS 456
            .  .:...|.....|::..|     :...|:..|:  :.:.::|...:....|
  Fly    63 H--HRGGHGGHHNHGNKVPY-----NGYNSEEYLDRLEPNGNIPADKTNCRYG------------ 108

  Fly   457 RSVSSKSSSQSSRSSRSRSRSRSQSSLEDEVDRQDVGADASPSSSTRSEERGMTQE--------- 512
                ::.|:::..:.....||...:...|.|.||     .|.||.::..:..:.:|
  Fly   109 ----AQESAKNDNNKPQDWRSTDSTDHHDRVQRQ-----LSVSSDSKLLDEDIREEMKYHSHVVM 164

  Fly   513 QPEEKPEEKLK---EKQKSLEEQIPCDDKGIPLPNYYPGVQGCRSVEEFQCLNRIEEGTYGVVYR 574
            :|::.|..|.:   .||::...:......|...|.   |.|     |.:..|..:.||:|..||:
  Fly   165 RPKKPPRPKSEVFLNKQETHPRRKRFSAFGGDSPF---GKQ-----EAYVKLEPLGEGSYATVYK 221

  Fly   575 AKDKRTNEIVALKRLKMEKEKEGFPITSLREINTLLKGQHPNIVTVREIVVGSNMDKIFIVMDYV 639
            ...|.|.:.||||.:::: |:||.|.|::||.:.|.:.:|.||||:.:||  ...:.:..|.:||
  Fly   222 GFSKLTYQRVALKEIRLQ-EEEGAPFTAIREASLLKELKHSNIVTLHDIV--HTRETLTFVFEYV 283

  Fly   640 EHDLKSLMETMKNRKQSFFPG-----EVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGIL 699
            ..||...||.        .||     .|:....||||.:::.|...:||||:|..|||:|..|.|
  Fly   284 NTDLSQYMEK--------HPGGLDHRNVRLFLFQLLRGLSYCHKRRVLHRDVKPQNLLISDCGEL 340

  Fly   700 KVGDFGLAREYGSPIKKYTSLVVTLWYRAPELLLCSPVYSTPIDVWSVGCIFAEFLQMLPLFPG- 763
            |:.||||||....|...|:..|||||||.|::||.|..|||.:|:|.|||||.|.:..:|.|||
  Fly   341 KLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTSLDMWGVGCIFVEMVTGMPTFPGI 405

  Fly   764 KSEIDELNRIFKELGTPNEKIWPGYTELPAVKNMLSQNSQFTEYPVSQLRKHFQEKTSEM-GLSL 827
            :...|:|::|||.||||.|..|||.|..|..|     ..:...|...:|..:|......: |.::
  Fly   406 RDTYDQLDKIFKLLGTPTEDTWPGVTHFPGYK-----PHKLGFYRPRKLGHNFPRLYDIIEGETI 465

  Fly   828 LQGLLTYDPKQRLSADAALKHGFFKELP-----LPIDPSMF 863
            ..|.|..:|:|||.||.||:|.:|.:||     ||.:.|:|
  Fly   466 ANGFLQLNPEQRLGADDALQHPYFAQLPKKLYELPDETSIF 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pitslre	NP_649251.2	STKc_CDC2L1	552..851	CDD:173741	120/305 (39%)
Pitslre	NP_649251.2	PLN00009	555..854	CDD:177649	121/305 (40%)
Eip63E	NP_001261373.1	PLN00009	203..492	CDD:177649	121/304 (40%)
Eip63E	NP_001261373.1	STKc_PCTAIRE_like	204..489	CDD:270835	119/300 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442398
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24056
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940