DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pitslre and CG7028

DIOPT Version :9

Sequence 1:	NP_649251.2	Gene:	Pitslre / 40292	FlyBaseID:	FBgn0016696	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_001286884.1	Gene:	CG7028 / 38032	FlyBaseID:	FBgn0027587	Length:	912	Species:	Drosophila melanogaster

Alignment Length:	1012	Identity:	227/1012 - (22%)
Similarity:	353/1012 - (34%)	Gaps:	311/1012 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 ASRESGSGPRREKKKHSRERRRHKERDDVGGAALALERDHRYDYRSREEHYHHHQRERSSNAAAA 107
            :|..|.:..||.|.|.:::.::|| :...|    ..|:|.....:.::.....|:...|:|.:.|
  Fly     9 SSNNSETEERRAKHKKAKKHKKHK-KSSTG----KTEKDRHVHKKQKKAKKRPHRTSESTNESDA 68

  Fly   108 --YAK----HHLGHAYHYPQPPQQQQQP----------LPPAPSYAAHHYH---HHQHLSGARAA 153
              .||    .:.|.:..:.:..|:..:.          ||..||.......   .::.|.....|
  Fly    69 PENAKLKLSQNCGLSSKFTEIMQKASRNGADFRVGKPLLPTDPSSLVEEITKTIQNKMLPVLEVA 133

  Fly   154 PREYHSYPSGYHSGSRHGDYPMEEPTRRSSKYAESKDAESLEQDLRSR-LLKKRHN-YVKDYETE 216
                        |.|...|.|.:..:.......|  |..:||:.:|.: ||:.|.. |:.|.|.|
  Fly   134 ------------SSSSESDVPADAASPIILSIIE--DELNLEELMRQKALLQARLGAYMSDPEAE 184

  Fly   217 EN-----YEH---------------------RVERSDRREGGRKERERTVR--STHKQNRHDRVI 253
            :.     :.|                     :..:|.........:...::  :||..|..|  :
  Fly   185 DKGDLLPHTHSQQLVVHTKSVLKAVTSVPQPQPSKSAAPLATATSKHANIKKSTTHNSNESD--V 247

  Fly   254 ELLD---------SPEQEHHHQHQH---KSHRSKWREEVEVIRRKVPEDLELLARREKLLAAERE 306
            .|||         ||..|...:|..   .:.||:.|.:    ||....|.....||    |::::
  Fly   248 ILLDDSSGGQRTPSPTPEKRRRHASPLPAAPRSRCRRD----RRSRDRDRSPPRRR----ASDQQ 304

  Fly   307 SRQRKQTAREEL-----EARRELLRERNEHS--------DALSPTTVAASVTAGLNIHVKRKSKP 358
            ::.|.::....:     |..|:..|||.:||        |...|.|
  Fly   305 TQVRPRSRNRNMEDLRQEINRDKQRERRDHSRDRDRRGLDRPPPPT------------------- 350

  Fly   359 DNYEKEIKLKKRREDDIEVIRDDDDE-----ESEESDSNEEVPEQDSEG------SATESGSEDS 412
                 :::..:.||.|:...|.....     ||:.....|...::|..|      |.|::|..|.
  Fly   351 -----DMRPGRARERDVRPSRMQRSHSRSKFESDRRRERERQKDRDRGGGRVGARSGTDNGDRDR 410

  Fly   413 Y---ASKKKSKIKSKSQ----------LEDDDEDLPLPDSPLSVGELYKSPKQRQRS----RSVS 460
            |   .|:.::|:..:|.          ||:|||:..:........||.|.....|.|    .|||
  Fly   411 YKGSLSEGQNKLDKESSDEEVNVNIDILEEDDEERIIELRRKKREELLKKLGTGQESPAPHNSVS 475

  Fly   461 SKSSSQSSRSSRSRSRSRSQS-------SLEDEV--DRQDVGADASPSSSTRSEERG---MTQEQ 513
            .:|.|.|..||:.....|:.|       .|..|:  ||:|:....|..:.:..|:|.   |..:|
  Fly   476 YESRSTSQGSSQRERPLRTPSPTMPCPNPLISEIPKDREDMDNSTSQKTCSAKEKRNEWDMFADQ 540

  Fly   514 -------------PEEKPEEKLKEKQKSLEEQIPCDDK--------GIPLPNYY--PGVQGCRSV 555
                         |....:.|.:.:..:|.:.  .||.        |..|.|.|  .|..|
  Fly   541 DVDSNFDVSRKISPNTIVQNKHQHENPALTDN--WDDAEGYYRVRIGEVLDNRYLVNGYTG---- 599

  Fly   556 EEFQCLNRIEEGTYGVVYRAKDKRTNEIVALKRLKMEKEKEGFPITSLREINTLLK--------- 611
                      :|.:..|.|.:|:...:  |...:|:.:..|....|.|||:..|.|
  Fly   600 ----------QGVFSNVVRGRDQARGQ--ANVAIKIIRNNEIMHKTGLRELEILKKLNDADPEDR 652

  Fly   612 ------------GQH------PNIVTVREIV--VGSNMDKIFIVMDYVEHDLKSLMETMKNRKQS 656
                        .||      |..:.:||::  .|.|          |...:|:
  Fly   653 FHCLRLYRHFFHKQHLCMVFEPLAMNLREVLKKYGKN----------VGLHIKA----------- 696

  Fly   657 FFPGEVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKG-ILKVGDFGLAREYGSPIKKYTSL 720
                 |:..||||..|:..|....|||.|:|..|:|::... |||:.|||.|.....  .:.|..
  Fly   697 -----VRSYTQQLFLALKLLKKTGILHADIKPDNILVNENNLILKLCDFGSASAISD--NEITPY 754

  Fly   721 VVTLWYRAPELLLCSPVYSTPIDVWSVGCIFAEFLQMLPLFPGKSEIDEL-----------NRI- 773
            :|:.:||:||::|..| |...||.||.||...|......||.|||....|           |||
  Fly   755 LVSRFYRSPEIILGIP-YDYGIDTWSAGCTIYELYTGKILFSGKSNNQMLKFFMDVKGKIPNRII 818

  Fly   774 ----FKELG---------------TPNEKIWPGYTELPAVKNMLSQNSQF---TEYPVSQLRKHF 816
                |:|..               |..|||    ..:|.||...|...:.   ...|..|.||..
  Fly   819 RKGQFREQHFDQSCNFLYHEIDKLTEREKI----VVMPVVKPSRSLQQELIADQNLPDDQHRKVT 879

  Fly   817 QEKTSEMGLSLLQGLLTYDPKQRLSADAALKHGFFKE 853
            |.|      .||:.:...||.:|:|.:.||.|.|.:|
  Fly   880 QLK------DLLENMFALDPAKRISLNQALVHPFIQE 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pitslre	NP_649251.2	STKc_CDC2L1	552..851	CDD:173741	93/362 (26%)
Pitslre	NP_649251.2	PLN00009	555..854	CDD:177649	95/363 (26%)
CG7028	NP_001286884.1	STKc_PRP4	591..908	CDD:271037	96/371 (26%)
CG7028	NP_001286884.1	S_TKc	599..908	CDD:214567	94/363 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442397
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24056
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030