DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pitslre and cdk-12

DIOPT Version :9

Sequence 1:	NP_649251.2	Gene:	Pitslre / 40292	FlyBaseID:	FBgn0016696	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_001367220.1	Gene:	cdk-12 / 175559	WormBaseID:	WBGene00007135	Length:	734	Species:	Caenorhabditis elegans

Alignment Length:	767	Identity:	205/767 - (26%)
Similarity:	316/767 - (41%)	Gaps:	161/767 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 SGYHSGSRHGDYPMEEPTRRSSK-----YAESKDAESLEQDLRSRLLKKRHNYVKDYETEENYEH 221
            |..|...|.|.|...|.||..|.     |::.|...| .|.:|.|....:.:....|: :.|:
Worm     7 SSTHERDRKGSYGHRERTRSHSGSPSRFYSKDKRGSS-RQGVRPRDRDSKDSISPQYK-QRNW-- 67

  Fly   222 RVERSDRREGGRKERERTVRSTHKQNRHDRVIELLDSPEQEHHHQHQHKSHRSKWREEVEVIRRK 286
                |....||.::|.|...|..|:.:              .:::.:.|..||:.|.
Worm    68 ----SRGGGGGGRDRGRNDFSYRKKGK--------------DYNKRRDKRSRSRSRH-------- 106

  Fly   287 VPEDLELLARREKLLAAERESRQRKQTAREELEAR-RELLRERNEHSDALSPTTVAASVTAGLNI 350
                     |..|...:.::|::|..:.....:.. ..|:.|..:|.|..|.:
Worm   107 ---------RSPKRSGSSKKSKRRNSSGSSSSDLMDTSLMSELKKHGDYGSSS------------ 150

  Fly   351 HVKRKSKPDNYEKEIKLKKRREDDIEVIRDDDDEESEESDSNE--EVPEQDSEGSATESGSEDSY 413
                |||.       |.:|||:          ...|..|.|.|  ::|...:..:.|......|:
Worm   151 ----KSKK-------KSRKRRK----------HSSSSSSSSGEAMDLPVSSNGMNVTAIPPPPSF 194

  Fly   414 ASKKKSKIKSKSQLEDDDEDLPLPDSPLSVGELYKSPKQRQRSRSVSSKSSSQSSRSSRSRSRSR 478
            .......:.|:.           |..||.....:.:|..|......|....|.....  :.:.|.
Worm   195 NINPFQPMFSQP-----------PPPPLPPNSQFMTPPPRPPPAPFSIPPPSVDIHF--AATASF 246

  Fly   479 SQSSLEDEVDRQDVGADAS--------PSSSTR-------SEERGMTQEQPEEKPEEKLKEKQKS 528
            |.||:.....:.|.||.:|        |..|.|       :..||....:|.:.
Worm   247 SLSSIPPPPPQTDGGASSSKRQDPLPMPPDSKRIATRPVITTRRGHATNRPSDS----------- 300

  Fly   529 LEEQIPCDDKGIPLPNYYPGVQGCRSVEEFQCLNRIEEGTYGVVYRAKDKRTNEIVALKRLKMEK 593
                          .::|.     .::..:..|::|.|||||.||:|.:..|.|.|||||:::|.
Worm   301 --------------DSWYK-----TNLTHYTMLDQIGEGTYGQVYKAVNNLTGEQVALKRVRLEN 346

  Fly   594 EKEGFPITSLREINTLLKGQHPNIVTVREIVVGS-NMDKI-------FIVMDYVEHDLKSLMETM 650
            ||||||||::|||..|.:..|.|||.:.:||:.. :||::       ::|.:||:|||..|:|:
Worm   347 EKEGFPITAIREIKILRQLHHKNIVRLMDIVIDDISMDELKRTRANFYLVFEYVDHDLIGLLES- 410

  Fly   651 KNRKQSFFPGEVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGILKVGDFGLAREYGSPIK 715
             .....|...::..|.:|||..:|::|:...||||:|.||:|:::||.||:.|.||||.:....:
Worm   411 -KELVDFNKDQICSLFKQLLEGLAYIHNTGFLHRDIKCSNILVNNKGELKIADLGLARLWEKESR 474

  Fly   716 KYTSLVVTLWYRAPELLLCSPVYSTPIDVWSVGCIFAEFLQMLPLFPGKSEIDELNRIFKELGTP 780
            .||:.|:|||||.|||||....|...|||||.||:..|.....|||.|.:|..:|..|.|..|:|
Worm   475 LYTNRVITLWYRPPELLLGDERYGPAIDVWSTGCMLGELFTRKPLFNGNNEFGQLELISKVCGSP 539

  Fly   781 NEKIWPGYTELPAVKNMLSQNSQFTEYPVSQLRKHFQEKTSEMGLSLLQGLLTYDPKQRLSADAA 845
            |...||..|||........:.:.     ..::|:.|:.......:.||..:||.:|::|:||..|
Worm   540 NVDNWPELTELVGWNTFRMKRTY-----QRRIREEFEHIMPREAVDLLDKMLTLNPEKRISAKEA 599

  Fly   846 LKHGFFKE--------LPLPIDPSMFPTWPAKSELGARKAQASSPKPPSGGS 889
            |.|.:.:.        |.||........|..|.:..||..:.:.....||.|
Worm   600 LNHPWIRSLEHTTVQPLKLPQHQDCHEMWSKKQKKSARLGRQAEGSSGSGHS 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pitslre	NP_649251.2	STKc_CDC2L1	552..851	CDD:173741	121/306 (40%)
Pitslre	NP_649251.2	PLN00009	555..854	CDD:177649	121/314 (39%)
cdk-12	NP_001367220.1	STKc_CDK12	303..605	CDD:270847	122/313 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925637at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920