Protein Alignment Pitslre and cdk-11.1

DIOPT Version :10

• Sequence 1: NP_649251.2
• Gene: Pitslre / 40292
• FlyBaseID: FBgn0016696
• Length: 952
• Species: Drosophila melanogaster
• Sequence 2: NP_495617.1
• Gene: cdk-11.1 / 174244
• WormBaseID: WBGene00015203
• Length: 719
• Species: Caenorhabditis elegans
• Alignment Length: 850
• Identity: 309/850 - (36%)
• Similarity: 426/850 - (50%)
• Gaps: 201/850 - (23%)

  Fly   165 HSGSRHGDYPMEEPTRRSSKYAESKDA-------ESLEQDLR----SRLLKKRHNYVKDYETEEN 218
            |.||.|.:..:.:.:.:.|:.|.|.|.       :.||..:|    |||.|::::...|..||:.
 Worm     4 HLGSSHDEGELSDESHKKSQRASSSDEPNPAKSNKGLESKMRESILSRLSKRKNSESDDDTTEQR 68

  Fly   219 Y-----------EHRV---ERSDRREGGRKERERTVRSTH----------KQNRHDRVIELLDSP 259
            :           |.|.   ||..:||..:::..|.||...          :|.|..|     |..
 Worm    69 FSIQPKNAQKAKEDRYRDKERDKKREKDKRDDRRDVRGPDARQKDRDFKGRQERSGR-----DQK 128

  Fly   260 EQEHHHQHQHKSHRSKWREEVEVIRRKVPEDLELLARREKLLAAERESRQRKQTAREELEARREL 324
            ..||.|.|.|:.|.:               |.....|..:..::||:|.:.|:..
 Worm   129 VHEHRHHHHHRKHET---------------DGHRTNRSNRDRSSERDSEKHKRHI---------- 168

  Fly   325 LRERNEHSDALSPTTVAASVTAGLNIHVKRKSKPDNYEKEIKL--------KKRREDDIEVIRDD 381
              :|::.|...||....:.         .:|||..:...:.||        .|:::||:.||.|.
 Worm   169 --DRHKKSSTTSPDNDKSP---------HKKSKHTDVPADAKLFDRILDPNYKKKDDDVLVIEDV 222

  Fly   382 DDEESEESDSNEEVPEQDSEGSATESGSEDSYASKKKSKIKSKSQLEDDDEDLPLPDSPLSVGEL 446
            :       .|..|:.|:..|....|...:.....||.||.:|..:.:.||
 Worm   223 E-------MSPIEILEEKEEKEIVEFTIDSPAGPKKYSKFESDPESDHDD--------------- 265

  Fly   447 YKSPKQRQRSRSVSSKSSSQSSRSSRSRSRSRSQSSLEDEVDRQDVGADASPSSSTRSEERGMTQ 511
                                        ::.:|....||:.|..:|..||..|......:.....
 Worm   266 ----------------------------TKPKSPGKAEDDDDVIEVLDDALHSDDDADSDEDKYL 302

  Fly   512 EQPEEKPEEKLKE----------------KQKSLEEQIPCDDKGIPLPNYYPGVQGCRSVEEFQC 560
            :.||::..|::.|                |||:|..|         ||.:|||:.|||:::|::|
 Worm   303 KTPEDREWEEMTETEQRLHKEAMKKRASMKQKTLIAQ---------LPVFYPGLMGCRNIDEYEC 358

  Fly   561 LNRIEEGTYGVVYRAKDKRTNEIVALKRLKMEKEKEGFPITSLREINTLLK-GQHPNIVTVREIV 624
            :||::|||:|||||.|||||:||||||||||||||||||||:|||||.||| |.|||||.|:||:
 Worm   359 VNRVDEGTFGVVYRGKDKRTDEIVALKRLKMEKEKEGFPITALREINMLLKAGNHPNIVNVKEIL 423

  Fly   625 VGSNMDKIFIVMDYVEHDLKSLMETMKNRKQSFFPGEVKCLTQQLLRAVAHLHDNWILHRDLKTS 689
            :|||||||::.|::||||:|||::||..|.:.|..||.|.|.||||..:.|:|..||||||||||
 Worm   424 LGSNMDKIYMAMEFVEHDMKSLLDTMSRRNKRFSIGEQKTLLQQLLSGIEHMHKLWILHRDLKTS 488

  Fly   690 NLLLSHKGILKVGDFGLAREYGSPIKKYTSLVVTLWYRAPELLLCSPVYSTPIDVWSVGCIFAEF 754
            |||:|||||||:.|||||||||.|:||:||:|||||||:|||||.:.:||||:|:||||||.|||
 Worm   489 NLLMSHKGILKIADFGLAREYGDPLKKFTSIVVTLWYRSPELLLGTRLYSTPVDMWSVGCIMAEF 553

  Fly   755 LQMLPLFPGKSEIDELNRIFKELGTPNEKIWPGYTELPAVKNMLSQNSQFTEYPVSQLRKHF--Q 817
            :.:.|||||:.|::::.:||.|:|||.|.||||.|||...|.:     .|.:||.:||||.|  .
 Worm   554 ILLKPLFPGRGELEQIKKIFMEMGTPTESIWPGVTELDGWKAL-----TFEKYPYNQLRKRFLAG 613

  Fly   818 EKTSEMGLSLLQGLLTYDPKQRLSADAALKHGFFKELPLPIDPSMFPTWPAKSELGARKAQASSP 882
            ...::.|..||.||||.|||.|.||..||.|.:|.|.|.|:.|..|||:|||||      |..:|
 Worm   614 RLLNDTGFKLLNGLLTLDPKNRFSATQALDHEWFTEEPYPVPPEEFPTFPAKSE------QNKAP 672

  Fly   883 KPPSGGSQFKQLGRDEPIIVGPGNKLSSGIITGNKKSHGAGGSSASTGFVLNAGITQRQLAMGPG 947
            .|.....|..::...:|                            .|..:|.....:.:.....|
 Worm   673 PPAKQKQQENRISHVDP----------------------------ETAKLLKQFEVRPEQVKPGG 709

  Fly   948 FSLKF 952
            |||||
 Worm   710 FSLKF 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pitslre	NP_649251.2	STKc_CDC2L1	552..851	CDD:173741	190/301 (63%)
cdk-11.1	NP_495617.1	STKc_CDC2L1	350..647	CDD:173741	190/301 (63%)