DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pitslre and cdk-11.1

DIOPT Version :9

Sequence 1:	NP_649251.2	Gene:	Pitslre / 40292	FlyBaseID:	FBgn0016696	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_495617.1	Gene:	cdk-11.1 / 174244	WormBaseID:	WBGene00015203	Length:	719	Species:	Caenorhabditis elegans

Alignment Length:	850	Identity:	309/850 - (36%)
Similarity:	426/850 - (50%)	Gaps:	201/850 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 HSGSRHGDYPMEEPTRRSSKYAESKDA-------ESLEQDLR----SRLLKKRHNYVKDYETEEN 218
            |.||.|.:..:.:.:.:.|:.|.|.|.       :.||..:|    |||.|::::...|..||:.
Worm     4 HLGSSHDEGELSDESHKKSQRASSSDEPNPAKSNKGLESKMRESILSRLSKRKNSESDDDTTEQR 68

  Fly   219 Y-----------EHRV---ERSDRREGGRKERERTVRSTH----------KQNRHDRVIELLDSP 259
            :           |.|.   ||..:||..:::..|.||...          :|.|..|     |..
Worm    69 FSIQPKNAQKAKEDRYRDKERDKKREKDKRDDRRDVRGPDARQKDRDFKGRQERSGR-----DQK 128

  Fly   260 EQEHHHQHQHKSHRSKWREEVEVIRRKVPEDLELLARREKLLAAERESRQRKQTAREELEARREL 324
            ..||.|.|.|:.|.:               |.....|..:..::||:|.:.|:..
Worm   129 VHEHRHHHHHRKHET---------------DGHRTNRSNRDRSSERDSEKHKRHI---------- 168

  Fly   325 LRERNEHSDALSPTTVAASVTAGLNIHVKRKSKPDNYEKEIKL--------KKRREDDIEVIRDD 381
              :|::.|...||....:.         .:|||..:...:.||        .|:::||:.||.|.
Worm   169 --DRHKKSSTTSPDNDKSP---------HKKSKHTDVPADAKLFDRILDPNYKKKDDDVLVIEDV 222

  Fly   382 DDEESEESDSNEEVPEQDSEGSATESGSEDSYASKKKSKIKSKSQLEDDDEDLPLPDSPLSVGEL 446
            :       .|..|:.|:..|....|...:.....||.||.:|..:.:.||
Worm   223 E-------MSPIEILEEKEEKEIVEFTIDSPAGPKKYSKFESDPESDHDD--------------- 265

  Fly   447 YKSPKQRQRSRSVSSKSSSQSSRSSRSRSRSRSQSSLEDEVDRQDVGADASPSSSTRSEERGMTQ 511
                                        ::.:|....||:.|..:|..||..|......:.....
Worm   266 ----------------------------TKPKSPGKAEDDDDVIEVLDDALHSDDDADSDEDKYL 302

  Fly   512 EQPEEKPEEKLKE----------------KQKSLEEQIPCDDKGIPLPNYYPGVQGCRSVEEFQC 560
            :.||::..|::.|                |||:|..|         ||.:|||:.|||:::|::|
Worm   303 KTPEDREWEEMTETEQRLHKEAMKKRASMKQKTLIAQ---------LPVFYPGLMGCRNIDEYEC 358

  Fly   561 LNRIEEGTYGVVYRAKDKRTNEIVALKRLKMEKEKEGFPITSLREINTLLK-GQHPNIVTVREIV 624
            :||::|||:|||||.|||||:||||||||||||||||||||:|||||.||| |.|||||.|:||:
Worm   359 VNRVDEGTFGVVYRGKDKRTDEIVALKRLKMEKEKEGFPITALREINMLLKAGNHPNIVNVKEIL 423

  Fly   625 VGSNMDKIFIVMDYVEHDLKSLMETMKNRKQSFFPGEVKCLTQQLLRAVAHLHDNWILHRDLKTS 689
            :|||||||::.|::||||:|||::||..|.:.|..||.|.|.||||..:.|:|..||||||||||
Worm   424 LGSNMDKIYMAMEFVEHDMKSLLDTMSRRNKRFSIGEQKTLLQQLLSGIEHMHKLWILHRDLKTS 488

  Fly   690 NLLLSHKGILKVGDFGLAREYGSPIKKYTSLVVTLWYRAPELLLCSPVYSTPIDVWSVGCIFAEF 754
            |||:|||||||:.|||||||||.|:||:||:|||||||:|||||.:.:||||:|:||||||.|||
Worm   489 NLLMSHKGILKIADFGLAREYGDPLKKFTSIVVTLWYRSPELLLGTRLYSTPVDMWSVGCIMAEF 553

  Fly   755 LQMLPLFPGKSEIDELNRIFKELGTPNEKIWPGYTELPAVKNMLSQNSQFTEYPVSQLRKHF--Q 817
            :.:.|||||:.|::::.:||.|:|||.|.||||.|||...|.:     .|.:||.:||||.|  .
Worm   554 ILLKPLFPGRGELEQIKKIFMEMGTPTESIWPGVTELDGWKAL-----TFEKYPYNQLRKRFLAG 613

  Fly   818 EKTSEMGLSLLQGLLTYDPKQRLSADAALKHGFFKELPLPIDPSMFPTWPAKSELGARKAQASSP 882
            ...::.|..||.||||.|||.|.||..||.|.:|.|.|.|:.|..|||:|||||      |..:|
Worm   614 RLLNDTGFKLLNGLLTLDPKNRFSATQALDHEWFTEEPYPVPPEEFPTFPAKSE------QNKAP 672

  Fly   883 KPPSGGSQFKQLGRDEPIIVGPGNKLSSGIITGNKKSHGAGGSSASTGFVLNAGITQRQLAMGPG 947
            .|.....|..::...:|                            .|..:|.....:.:.....|
Worm   673 PPAKQKQQENRISHVDP----------------------------ETAKLLKQFEVRPEQVKPGG 709

  Fly   948 FSLKF 952
            |||||
Worm   710 FSLKF 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pitslre	NP_649251.2	STKc_CDC2L1	552..851	CDD:173741	190/301 (63%)
Pitslre	NP_649251.2	PLN00009	555..854	CDD:177649	189/301 (63%)
cdk-11.1	NP_495617.1	STKc_CDC2L1	350..647	CDD:173741	190/301 (63%)
cdk-11.1	NP_495617.1	PLN00009	353..647	CDD:177649	188/298 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	383	1.000	Domainoid score	I432
eggNOG	1	0.900	-	-		E1_KOG0663
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	474	1.000	Inparanoid score	I822
Isobase	1	0.950	-	0	Normalized mean entropy	S790
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D392617at33208
OrthoFinder	1	1.000	-	-		FOG0001516
OrthoInspector	1	1.000	-	-		otm14318
orthoMCL	1	0.900	-	-		OOG6_102464
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R970
SonicParanoid	1	1.000	-	-		X2585
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.810