DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pitslre and cdk12

DIOPT Version :9

Sequence 1:	NP_649251.2	Gene:	Pitslre / 40292	FlyBaseID:	FBgn0016696	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	XP_003200579.2	Gene:	cdk12 / 100149834	ZFINID:	ZDB-GENE-081104-294	Length:	1293	Species:	Danio rerio

Alignment Length:	1058	Identity:	270/1058 - (25%)
Similarity:	418/1058 - (39%)	Gaps:	270/1058 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 EEDEHEGDADALYIQP----PQASRESG-----------SGPRREKKKHSRERRRHKERD----- 69
            |.|:...|:|.....|    |..:|::.           :|..:|.:.|.|:|.|.|.:|
Zfish    85 EYDDISSDSDTFLDSPATGNPVDTRDAEQLDLSDYGEVVAGVAKENRTHKRKRSRKKSKDRHRVR 149

  Fly    70 -----DVGGAALALERDHRYDYRSREEHYHHHQRERSSNAA--AAYAKHHLGHAYHYPQPPQQQQ 127
                 .||......:|: |....||::     .:||:|..|  ||.:....|..
Zfish   150 ESAERPVGAKKSIKDRE-RVSKESRKK-----VKERASPVACLAASSSRRSGET----------- 197

  Fly   128 QPLPPAPSYAAHHYHHHQHLSGARAAPREYHSYPSGYHSGSRHGDYPMEEPTRRSSKYAESKDAE 192
                           ..:.|.|..:....  :..|....||             |:..|.|..::
Zfish   198 ---------------GAKKLGGGESVSSS--AVQSAVSLGS-------------SASSASSSISK 232

  Fly   193 SLEQDLRSRLLKKRHNYVKDYETEENYEHRVERSDRREG--GRKERERTVRSTHKQNRHDRVIEL 255
            ...:..:||..|:|:.     |.||:..||.....|:..  |:.:..|||
Zfish   233 ESVRSSKSRKEKRRNE-----EYEEDRSHRKAAKSRKSSPKGKSQSRRTV--------------- 277

  Fly   256 LDSP---EQEHHHQHQHKS----------HRSKWREEVEVIRRK--VPE--DLELLARREKLLA- 302
            :|||   |.|:.:..:.|:          .||:.|.|....||:  .||  ....::|:....:
Zfish   278 VDSPSVAELENSYSSKRKAASPSPYREPPRRSRQRSESPYGRRRSSSPEKDGSPYVSRKHSPGSP 342

  Fly   303 -AERESRQRKQTAREELEA----------RRELLRERNE--------------HSD---ALSPTT 339
             |.|.|......:|..|.|          ||.....|::              ||.   :.||::
Zfish   343 YASRRSPSSSPVSRTSLRARSRSPHYSSSRRSTSHSRSKKHSLYSGGASGASSHSSRPGSRSPSS 407

  Fly   340 VAASVTAGLNIHVKRKSKPDNYEKEIKLKKR----REDDIEV----IRDDDDEESEESDSNEEVP 396
            ....:|:.|...:.|:.:    |::....|.    :.:...|    :::.|....|.:.:....|
Zfish   408 SRLPITSSLGAELTRRKQ----ERQAAAAKNSPALQPNTSNVTNTPVKNTDPPPLETAAAAAAPP 468

  Fly   397 EQD---SEGSATESGSEDSYASKKKSKIKSKSQLEDDDEDLPLPDS-----------PLSVGELY 447
            |..   |..:.|.:..|.:........:.|...|...... |||.|           ||.:....
Zfish   469 EPQRPPSPPAITVAVEEPAALPPPPLPLSSPPPLPLTSPP-PLPASSPPPPPLSSPPPLPLNSPP 532

  Fly   448 KSPKQRQRSRSVSSKSSSQSSRSSRSRSRSRSQSSLEDEV-------DRQDVGADASPSSSTRSE 505
            .:|.....:.::||:..|.:.:.::|.:.....|:|....       |.:|     ||..|
Zfish   533 PAPPPLAPAPALSSRPKSPAQKPAKSPAHQMKTSTLPPLPLPPALLGDCRD-----SPKKS---- 588

  Fly   506 ERGMTQEQPEEKPEEKLKEKQKSLEEQI-------PCDDKGIPLPNYYPG------VQ------- 550
              |::| :...|..||.|||:|.:..::       |....|.|.|...|.      :|
Zfish   589 --GLSQ-RLSRKEREKEKEKEKEVRTRLLSELPLPPVLSGGDPSPPQSPARVSPPLLQPSFKKRP 650

  Fly   551 -----------------GCRSVEEFQCLNRIEEGTYGVVYRAKDKRTNEIVALKRLKMEKEKEGF 598
                             |.|.|::|..:..|.|||||.||:||||.|.|:||||:::::.|||||
Zfish   651 KICSPRYGERKQTQTDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGF 715

  Fly   599 PITSLREINTLLKGQHPNIVTVREIVVGS------NMDK--IFIVMDYVEHDLKSLMETMKNRKQ 655
            |||::|||..|.:..|.::|.::|||...      ..||  .::|.:|::|||..|:|   :...
Zfish   716 PITAIREIKILRQLNHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLE---SGLV 777

  Fly   656 SFFPGEVKCLTQQLLRAVAHLHDNWILHRDLKTSNLLLSHKGILKVGDFGLAREYGS-PIKKYTS 719
            ||....|:...:||:..:.:.|....||||:|.||:||::.|.:|:.||||||.|.| ..:.||:
Zfish   778 SFSHEHVQSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTN 842

  Fly   720 LVVTLWYRAPELLLCSPVYSTPIDVWSVGCIFAEFLQMLPLFPGKSEIDELNRIFKELGTPNEKI 784
            .|:|||||.|||||....||..|||||.|||..|.....|:|....|:.:|..|.:..|:|....
Zfish   843 KVITLWYRPPELLLGEERYSPAIDVWSCGCILGELFTKKPIFQANQELLQLELISRLCGSPCPAA 907

  Fly   785 WPGYTELPAVKNMLSQNSQFTEYPVSQLRKHFQEKTSEM---GLSLLQGLLTYDPKQRLSADAAL 846
            ||....||....|         .|..|.|:..:|:.|.:   .|.||..:||.||.:|.:|:.||
Zfish   908 WPDVIRLPYFNTM---------RPKKQYRRRLREEFSFLPTPALDLLDHMLTLDPSRRCTAEQAL 963

  Fly   847 KHGFFKEL-PLPIDPSMFPTWPAKSELGARKAQASSPKPPSGGSQFKQLGRDEPIIVGPGNKLSS 910
            ...|..:: |..:.|...|.|....||.::|.:.   :..||.|:      |.|:...|
Zfish   964 ASQFLCDVEPNKMPPPDLPHWQDCHELWSKKRRR---QRQSGVSE------DLPVAKVP------ 1013

  Fly   911 GIITGNKKSHGAGGSSAS 928
                 .|:..||.|...|
Zfish  1014 -----RKEPAGASGGENS 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pitslre	NP_649251.2	STKc_CDC2L1	552..851	CDD:173741	124/310 (40%)
Pitslre	NP_649251.2	PLN00009	555..854	CDD:177649	124/310 (40%)
cdk12	XP_003200579.2	STKc_CDK12	667..968	CDD:270847	125/312 (40%)
cdk12	XP_003200579.2	S_TKc	675..968	CDD:214567	122/304 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925637at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920