DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4042 and Dmac2

DIOPT Version :9

Sequence 1:	NP_001262121.1	Gene:	CG4042 / 40291	FlyBaseID:	FBgn0037018	Length:	284	Species:	Drosophila melanogaster
Sequence 2:	NP_001277416.1	Gene:	Dmac2 / 66349	MGIID:	1913599	Length:	258	Species:	Mus musculus

Alignment Length:	255	Identity:	75/255 - (29%)
Similarity:	118/255 - (46%)	Gaps:	42/255 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 EVSATVKRIR--SELAA-DKQKLKWRTP---IGDRPEDWNSKLKLFSNAEQTSDFIVMMQKPIDL 94
            |.:...:||.  |||.. |..:.|.||.   :.|.          |.:.:...::  ::||.|..
Mouse    14 EWNGRARRIHGMSELVTPDSSREKKRTLLQFLSDH----------FQDIQTLREY--LLQKQISK 66

  Fly    95 SPRNIRQWWENREERIERHMQQFVPERHKILGAELAAAHFILYRGGAVKFINDTHWRRASKDGEF 159
                     .|||.|...::|    |::   |..:|.|.|||.:||||||.:...|.|.:....|
Mouse    67 ---------VNRENRSFTNIQ----EKY---GPYVAGAVFILKQGGAVKFQDKEEWIRPNNRSHF 115

  Fly   160 KLPNKFDPRYKVEALRCDNMELYYEGLENLRCLDSLKFLSFHNVKSFDDWCLDR---ISGGGFPN 221
            ....:......|||:......:.|:||.||..|..|:.||.....:.|||||.|   ::|    :
Mouse   116 LAEIQKFQNVPVEAVDASGCAINYQGLSNLLPLKELRSLSLQRCPNLDDWCLSRLYLLAG----S 176

  Fly   222 LEVLDLS-CTQITSNGLACLYRFPKLKLLILNDPKETLELELSTVMLEEAMPALKIVGAD 280
            |:.|.|: |.:|:..|||||:....|:.|.::|........|:.:::||.:|..:::|||
Mouse   177 LQELSLAGCPRISERGLACLHHLQNLRRLDISDLPAVSHPGLTQILVEEMLPHCEVLGAD 236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4042	NP_001262121.1	leucine-rich repeat	192..221	CDD:275381	11/31 (35%)
CG4042	NP_001262121.1	leucine-rich repeat	222..245	CDD:275381	10/23 (43%)
Dmac2	NP_001277416.1	leucine-rich repeat	127..140	CDD:275381	3/12 (25%)
		AMN1	149..>221	CDD:187754	24/75 (32%)
		leucine-rich repeat	151..176	CDD:275381	10/28 (36%)
		leucine-rich repeat	177..201	CDD:275381	10/23 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839430
Domainoid	1	1.000	87	1.000	Domainoid score	I7969
eggNOG	1	0.900	-	-		E1_KOG3864
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I5120
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007152
OrthoInspector	1	1.000	-	-		oto95395
orthoMCL	1	0.900	-	-		OOG6_109418
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4273
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.680