Protein Alignment CG4042 and DMAC2

DIOPT Version :10

• Sequence 1: NP_649250.2
• Gene: CG4042 / 40291
• FlyBaseID: FBgn0037018
• Length: 284
• Species: Drosophila melanogaster
• Sequence 2: NP_001161339.1
• Gene: DMAC2 / 55101
• HGNCID: 25496
• Length: 263
• Species: Homo sapiens
• Alignment Length: 213
• Identity: 67/213 - (31%)
• Similarity: 103/213 - (48%)
• Gaps: 45/213 - (21%)

  Fly    97 RNIRQWWEN--------REERIERHMQQ---------FVPERHKILGAELAAAHFILYRGGAVKF 144
            |.|.|:..|        |:..::|.|.:         ::.::|...|   |.|.|||.:||||||
Human    45 RTILQFLTNYFYDVEALRDYLLQREMYKVHEKNRSYTWLEKQHGPYG---AGAFFILKQGGAVKF 106

  Fly   145 INDTHWRRASKDGEF--------KLPNKFDPRYKVEALRCDNMELYYEGLENLRCLDSLKFLSFH 201
             .|..|.|..|.|.|        ::|        |||:...:.::.||||:||..|..|:.||..
Human   107 -RDKEWIRPDKYGHFSQEFWNFCEVP--------VEAVDAGDCDINYEGLDNLLRLKELQSLSLQ 162

  Fly   202 NVKSFDDWCLDRISGGGFP---NLEVLDLS-CTQITSNGLACLYRFPKLKLLILNDPKETLELEL 262
            .....|||||.|:    :|   :|:.|.|: |.:|:..|||||:....|:.|.::|........|
Human   163 RCCHVDDWCLSRL----YPLADSLQELSLAGCPRISERGLACLHHLQNLRRLDISDLPAVSNPGL 223

  Fly   263 STVMLEEAMPALKIVGAD 280
            :.:::||.:|..::||.|
Human   224 TQILVEEMLPNCEVVGVD 241

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4042	NP_649250.2	leucine-rich repeat	192..221	CDD:275381	11/31 (35%)
		leucine-rich repeat	222..245	CDD:275381	10/23 (43%)
DMAC2	NP_001161339.1	leucine-rich repeat	132..155	CDD:275381	10/22 (45%)
		PPP1R42	<145..>214	CDD:455733	28/72 (39%)
		leucine-rich repeat	156..181	CDD:275381	10/28 (36%)
		leucine-rich repeat	182..206	CDD:275381	10/23 (43%)
		leucine-rich repeat	207..227	CDD:275381	4/19 (21%)