DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG13252 and VWF

DIOPT Version :9

Sequence 1:NP_649248.3 Gene:CG13252 / 40289 FlyBaseID:FBgn0037016 Length:384 Species:Drosophila melanogaster
Sequence 2:NP_000543.3 Gene:VWF / 7450 HGNCID:12726 Length:2813 Species:Homo sapiens


Alignment Length:320 Identity:66/320 - (20%)
Similarity:94/320 - (29%) Gaps:108/320 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 CPPDAEM------------QCPADSSIRHNLL--------------AVDLIKSNAVELPNASEMA 81
            ||||..|            ||..:..::|..|              .:...|.|....|..:..|
Human  2237 CPPDKVMLEGSCVPEEACTQCIGEDGVQHQFLEAWVPDHQPCQICTCLSGRKVNCTTQPCPTAKA 2301

  Fly    82 SAADGVSYNRGLISDEDYVQCCLNRKCVCK------------------------------TCYI- 115
            ... |:.....|..:.|  |||...:|||.                              ||.. 
Human  2302 PTC-GLCEVARLRQNAD--QCCPEYECVCDPVSCDLPPVPHCERGLQPTLTNPGECRPNFTCACR 2363

  Fly   116 ---------PDCPSDADEDVVVVELVPENNQTPGECCGTYECQAEPNC---TVVRDTDFHWLKQC 168
                     |.||.         ..:|...:|  :||..|||..  ||   ||.....:......
Human  2364 KEECKRVSPPSCPP---------HRLPTLRKT--QCCDEYECAC--NCVNSTVSCPLGYLASTAT 2415

  Fly   169 RRCKCESGLKICHKTCDERAEGVCQSKISGMFYKDGENWTENCKTCECEKGE--------PKCTM 225
            ..|.|.:...:..|.|..|:          ..|..|:.|.|.|..|.|...|        .:|:.
Human  2416 NDCGCTTTTCLPDKVCVHRS----------TIYPVGQFWEEGCDVCTCTDMEDAVMGLRVAQCSQ 2470

  Fly   226 SFCGNLNCPSE-QQVMLKDTCCPVCWPK-CAPMPHEKQDD--GSYEDYVDESETPEEDSL 281
            ..|.: :|.|. ..|:.:..||..|.|. |..:....:.|  .|::....:..:||...|
Human  2471 KPCED-SCRSGFTYVLHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVGSQWASPENPCL 2529

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG13252NP_649248.3 VWC 197..249 CDD:302663 15/60 (25%)
VWFNP_000543.3 VWD 35..179 CDD:395046
C8 222..291 CDD:214843
TIL 295..348 CDD:410995
VWC 350..>394 CDD:327433
VWD 377..540 CDD:214566
C8 584..648 CDD:400886
TIL 652..707 CDD:410995
Amino-terminal 764..787
E1 788..833
TIL <788..827 CDD:410995
CX 826..853
VWD 856..1011 CDD:214566
C8 1053..1127 CDD:214843
TIL 1146..1196 CDD:410995
VWA_N2 1198..1276 CDD:406551
VWA 1277..1449 CDD:214621
VWA 1498..1658 CDD:395045
VWA 1691..1862 CDD:395045
VWD 1950..2102 CDD:395046
C8 2138..2199 CDD:400886
TIL 2203..2254 CDD:410995 5/16 (31%)
E2 2216..2261 7/23 (30%)
VWC 2261..2321 CDD:214564 11/62 (18%)
VWC 2431..2494 CDD:214564 17/73 (23%)
Cell attachment site 2507..2509 0/1 (0%)
VWC 2582..2644 CDD:278520
CT 2727..2808 CDD:214482
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1216
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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