DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13252 and Vwce

DIOPT Version :9

Sequence 1:	NP_649248.3	Gene:	CG13252 / 40289	FlyBaseID:	FBgn0037016	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_082189.1	Gene:	Vwce / 71768	MGIID:	1919018	Length:	929	Species:	Mus musculus

Alignment Length:	356	Identity:	78/356 - (21%)
Similarity:	116/356 - (32%)	Gaps:	107/356 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 PDAEMQCPADSSIRHNLLAVDLIKSNAVELPNA-----SEMASAAD------GVSYNRGLISDED 98
            |...:..|..||.....|....:...||..|::     |....|..      |.:|..|  |..:
Mouse   330 PTQLISTPVPSSSPLGTLGPPSLLQGAVGTPSSPRGPESPKLGAGSSSCWHLGATYESG--SRWN 392

  Fly    99 YVQCCLNRKCVCK----TCYIPDCPSDADEDVVVVELVPENNQTPGECC----GTYECQA----- 150
            ...|   .:|:|:    ||....|      |......||..:   |.||    |.:...|
Mouse   393 QPGC---SQCLCQDGEVTCGGVRC------DATCSHPVPPRD---GGCCPSCTGCFHSGAIRAEG 445

  Fly   151 ------EPNCTVVRDTDFHWLKQCRRCKCESGLKICHKTCDERAEGVCQSK-------------- 195
                  |.||||              |.|.:|...|  ...|...|.|::.
Mouse   446 DVFSPPEENCTV--------------CVCLAGNVSC--ISPECPPGPCKASPQSDCCTCVPGRCY 494

  Fly   196 ISGMFYKDGENWT---ENCKTCECEKGEPKCTMSFCGNLNCPSEQQVMLKDTCCPVCWPKCAPMP 257
            ..|.:|.||..::   ::|.||.|:.||.:|:.:.|..|.||.|:.::....||..| .:..|..
Mouse   495 FHGRWYTDGAVFSGGGDDCTTCVCQNGEVECSFTPCPELECPREEWLLGPGQCCFTC-REPTPTT 558

  Fly   258 HEKQDDGSYEDYVDESETPEE---------------------DSLP-PL-LPDPLTTQQSAELVA 299
            ....||...|..:.:..:|.:                     ||.| |: :|.......||....
Mouse   559 GCSLDDNGVEFPIGQIWSPGDPCELCVCQADGSVSCKRTDCVDSCPHPIRIPGQCCPDCSAGCTY 623

  Fly   300 TSTTTSSNGTTSTTVVP------LAATVNCN 324
            |.....:|.|..:.:.|      |..:|.|:
Mouse   624 TGRIFYNNETFPSVLDPCLSCICLLGSVACS 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13252	NP_649248.3	VWC	197..249	CDD:302663	18/54 (33%)
Vwce	NP_082189.1	EGF_CA	142..180	CDD:214542
		cEGF	200..223	CDD:289433
		EGF_CA	220..262	CDD:214542
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	291..317
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	339..374		7/34 (21%)
		VWC	378..432	CDD:302663	16/67 (24%)
		VWC	493..551	CDD:302663	18/57 (32%)
		VWC	564..617	CDD:214564	8/52 (15%)
		VWC	621..676	CDD:302663	7/34 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	731..774
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	791..861
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	879..929
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900