DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13252 and VWCE

DIOPT Version :9

Sequence 1:	NP_649248.3	Gene:	CG13252 / 40289	FlyBaseID:	FBgn0037016	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	NP_689931.2	Gene:	VWCE / 220001	HGNCID:	26487	Length:	955	Species:	Homo sapiens

Alignment Length:	379	Identity:	84/379 - (22%)
Similarity:	123/379 - (32%)	Gaps:	112/379 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 TTLDQEPLPDLCQSVKCPP----DAEMQCPA-DSSIRHNLLAVDLIKSNAVELPNA---SEMASA 83
            ||....|.|.|..|....|    ...:..|. .:|:..||....|::...:..|::   .|....
Human   315 TTRLPSPTPRLPTSSPSAPVWLLSTLLATPVPTASLLGNLRPPSLLQGEVMGTPSSPRGPESPRL 379

  Fly    84 ADGVS---------YNRGLISDEDYVQC-CLNRKCVCK------TCYIPDCPSDADEDVVVVELV 132
            |.|.|         .:|...::....|| |.:.|..|:      .|..|               :
Human   380 AAGPSPCWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAACSHP---------------I 429

  Fly   133 PENNQTPGECCGTYECQAEPNCT------VVR---DTDFHWLKQCRRCKCESGLKICHKTCDERA 188
            |..:   |.||        |:||      |||   |......:.|..|.|.:|...|  ...|..
Human   430 PSRD---GGCC--------PSCTGCFHSGVVRAEGDVFSPPNENCTVCVCLAGNVSC--ISPECP 481

  Fly   189 EGVCQSK--------------ISGMFYKDGENWT---ENCKTCECEKGEPKCTMSFCGNLNCPSE 236
            .|.||:.              ..|.:|.||..::   :.|.||.|:.||.:|:...|..|.||.|
Human   482 SGPCQTPPQTDCCTCVPVRCYFHGRWYADGAVFSGGGDECTTCVCQNGEVECSFMPCPELACPRE 546

  Fly   237 QQVMLKDTCCPVCWPKCAPMPHE--KQDDGSYEDYVDESETPEE--------------------- 278
            :..:....||..|.   .|.|..  ..||...|..:.:..:|.:
Human   547 EWRLGPGQCCFTCQ---EPTPSTGCSLDDNGVEFPIGQIWSPGDPCELCICQADGSVSCKRTDCV 608

  Fly   279 DSLP-PL-LPDPLTTQQSAELVATSTTTSSNGTTSTTVVP------LAATVNCN 324
            ||.| |: :|.......||....|.....:|.|..:.:.|      |..:|.|:
Human   609 DSCPHPIRIPGQCCPDCSAGCTYTGRIFYNNETFPSVLDPCLSCICLLGSVACS 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13252	NP_649248.3	VWC	197..249	CDD:302663	18/54 (33%)
VWCE	NP_689931.2	EGF_CA	142..180	CDD:214542
		cEGF	200..223	CDD:315355
		EGF_CA	220..262	CDD:214542
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..329		5/13 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..380		2/19 (11%)
		VWC	386..440	CDD:327433	13/79 (16%)
		VWC	501..559	CDD:327433	18/57 (32%)
		VWC	572..625	CDD:214564	8/52 (15%)
		VWC	629..684	CDD:327433	7/34 (21%)
		VWC	687..742	CDD:327433
		Atrophin-1	<726..944	CDD:331285
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	812..889
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	903..955
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900