DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13252 and muc5.1

DIOPT Version :9

Sequence 1:	NP_649248.3	Gene:	CG13252 / 40289	FlyBaseID:	FBgn0037016	Length:	384	Species:	Drosophila melanogaster
Sequence 2:	XP_021326297.1	Gene:	muc5.1 / 100148804	ZFINID:	ZDB-GENE-120822-1	Length:	5282	Species:	Danio rerio

Alignment Length:	384	Identity:	79/384 - (20%)
Similarity:	121/384 - (31%)	Gaps:	114/384 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 DLCQSVKCPPDAEMQCPADSSIRHNLLAVDLIKSNAVELPNASEMASAADGVSYNRGLISDEDYV 100
            ::|:.|..|...    |.|..........:.:.|     |..|......|...:.:..:|  |..
Zfish   231 EICEEVTLPSTG----PCDELSEQASFCEEYLIS-----PGFSGCYDVMDMRIFQKACVS--DLC 284

  Fly   101 QCCLNRKCVCKTCYIPDCPSDADEDVVVVELVPENNQTPGECCGTYECQAEPNCTVVRDTDFHWL 165
            ||..|..|:|.|               :.|:..:.....|: .||:  :.|..|......:..:|
Zfish   285 QCYGNHDCLCNT---------------LTEISRQCTHAGGQ-PGTW--RTEQLCPKTCPLNLQYL 331

  Fly   166 K---QCRR-CKCESGLKICHKTCDERA---EGVCQSKI---------------SGMFYKDGENWT 208
            :   .||. |...:...:|...|.:..   ||..:..|               .|..||.||::.
Zfish   332 ECGGPCRNTCSAPTANLMCTDHCVDGCFCPEGTVEDDIGQSGCVPVNECPCVHDGTVYKSGESYQ 396

  Fly   209 ENCKTCECEKGEPKCTMSFCGNLNCPSEQQVMLKDTC---------------------CPVCWPK 252
            :.||:|.|:.|...||.     |:||.        ||                     |.....|
Zfish   397 QACKSCTCDAGHWTCTY-----LDCPG--------TCSVVGGSHVTTFDGKSFTFSGNCDYILTK 448

  Fly   253 CAPMPHEKQDDGSYEDYVDESETPEEDSLPPLLPDPLTTQQSAELVATSTTT--SSNGTTSTTVV 315
                 |....|.:....:.:.|....|          |...|..||.:.||.  ||:|.
Zfish   449 -----HSADSDFAVVGNLAKCEASRTD----------TCLHSVTLVISGTTISFSSSGD------ 492

  Fly   316 PLAATVNCNNAFDQPKVVEVVN--QTNYYFYWLVPYSVIASIAIV-VMSFYIYQQRAKK 371
               .|:|..|:.:.|..:..|:  |.:..|..:...||...|.:. ||..||.....:|
Zfish   493 ---VTLNNINSKELPFSIGPVSIFQPSSSFIIVDLTSVRLEIQLAPVMQLYIVASTEEK 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13252	NP_649248.3	VWC	197..249	CDD:302663	18/72 (25%)
muc5.1	XP_021326297.1	VWD	72..217	CDD:214566
		C8	263..320	CDD:312319	15/76 (20%)
		TIL	324..380	CDD:307783	9/55 (16%)
		VWD	420..571	CDD:306577	31/153 (20%)
		C8	606..680	CDD:214843
		Pacifastin_I	848..>874	CDD:253170
		VWD	867..1025	CDD:214566
		C8	1063..1135	CDD:214843
		Mucin2_WxxW	1386..1476	CDD:315900
		Mucin2_WxxW	1631..1721	CDD:315900
		Mucin2_WxxW	1895..1985	CDD:315900
		Mucin2_WxxW	2141..2231	CDD:315900
		Mucin2_WxxW	2366..2456	CDD:315900
		Mucin2_WxxW	2612..2702	CDD:315900
		Mucin2_WxxW	2814..2904	CDD:315900
		Mucin2_WxxW	3060..3150	CDD:315900
		Mucin2_WxxW	3306..3396	CDD:315900
		Mucin2_WxxW	3552..3642	CDD:315900
		Mucin2_WxxW	3798..3888	CDD:315900
		VWD	4616..4779	CDD:214566
		C8	4818..4880	CDD:312319
		CT	5198..5274	CDD:214482
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900