DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cmpy and CRIM1

DIOPT Version :9

Sequence 1:	NP_001097652.1	Gene:	cmpy / 40288	FlyBaseID:	FBgn0037015	Length:	273	Species:	Drosophila melanogaster
Sequence 2:	XP_011531200.1	Gene:	CRIM1 / 51232	HGNCID:	2359	Length:	1077	Species:	Homo sapiens

Alignment Length:	255	Identity:	66/255 - (25%)
Similarity:	96/255 - (37%)	Gaps:	95/255 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 RGLAGKQQHNNAKLPLRMRSNGSYFGRLNVSALLIYLWCYLLLVMAASGGSNHVVNGLKCY-CNP 93
            |||||                   .|.|.||.|      .|||::|.||     ...|.|. |:.
Human     8 RGLAG-------------------CGHLLVSLL------GLLLLLARSG-----TRALVCLPCDE 42

  Fly    94 KECDVIRSPDCPGKGLMLWDPCKCCRICAKTLGESCGGPGGFSGQCEPPLQCVTKLPISSG---- 154
            .:|:..|  :|||.  ::...|.||..||....|||||..|..|.|:..|:||.:.|::..
Human    43 SKCEEPR--NCPGS--IVQGVCGCCYTCASQRNESCGGTFGIYGTCDRGLRCVIRPPLNGDSLTE 103

  Fly   155 --LGVCMDLQHLTALTYSQH------------------------------DNCSDSDSIVLEP-- 185
              .||| ::..|....|.:|                              :|.:|...:..:|
Human   104 YEAGVC-EVFSLNDKIYGKHGISDTPTAPRLPFLKKELEEPSDVSSYLEDENWTDDQLLGFKPCN 167

  Fly   186 -----GCEITNKRCQCWPTMRTCLSELTSDGGSPDDSRWHFKNLEDCQLNLQNLIKLEQE 240
                 ||.|.|.:|:| .|:|||            .:.:.|.:.:.|   |..|.::|:|
Human   168 ENLIAGCNIINGKCEC-NTIRTC------------SNPFEFPSQDMC---LSALKRIEEE 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cmpy	NP_001097652.1	IGFBP	91..145	CDD:395164	20/53 (38%)
CRIM1	XP_011531200.1	IGFBP	39..90	CDD:278641	20/54 (37%)
		VWC	377..431	CDD:214564
		VWC	444..497	CDD:214564
		Antistasin	608..633	CDD:280912
		VWC	653..703	CDD:302663
		VWC	724..775	CDD:302663
		VWC	799..849	CDD:214564
		VWC	860..914	CDD:302663
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910