DRSC/TRiP Functional Genomics Resources

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Protein Alignment kni and NR1D1

DIOPT Version :10

Sequence 1:NP_001287130.1 Gene:kni / 40287 FlyBaseID:FBgn0001320 Length:434 Species:Drosophila melanogaster
Sequence 2:NP_068370.1 Gene:NR1D1 / 9572 HGNCID:7962 Length:614 Species:Homo sapiens


Alignment Length:398 Identity:97/398 - (24%)
Similarity:142/398 - (35%) Gaps:97/398 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 NLMNQTCKVCGEPAAGFHFGAFTCEGCKSFFGRSYNNISTISECKNEGKCIIDKKNRTTCKACRL 68
            |.|...|||||:.|:|||:|...|||||.||.||.........|.....|.|.:.||..|:.||.
Human   126 NGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQCRF 190

  Fly    69 RKCYNVGMSKGGSRYGRRSNWFKIHCLLQEHEQAAAAAGKAPPLAGGVSVGGAPSASSPVGSPHT 133
            :||.:||||:...|:||...        :|.::..|....|..||........|..:||...| |
Human   191 KKCLSVGMSRDAVRFGRIPK--------REKQRMLAEMQSAMNLANNQLSSQCPLETSPTQHP-T 246

  Fly   134 PGFGDMAAHLHHHHQQQQQQQVPRHPH-------MPLLG---YPSYLSDPSAALP------FFSM 182
            ||                    |..|.       .||:|   :|..|:.|.:..|      ..|.
Human   247 PG--------------------PMGPSPPPAPVPSPLVGFSQFPQQLTPPRSPSPEPTVEDVISQ 291

  Fly   183 MGGVPHQSPFQLPPHLL--FPGYHASAAAAAASAADAAYRQE---------------MYKHRQSV 230
            :... |:..|......|  .||...:..|:.:..|...:|.|               ..:|.:::
Human   292 VARA-HREIFTYAHDKLGSSPGNFNANHASGSPPATTPHRWENQGCPPAPNDNNTLAAQRHNEAL 355

  Fly   231 DSVESQNRFSPASQPPVVQPTSSARQSPIDVCLEEDVHSVHSHQSSASLLHPIAIRATPTTPTSS 295
            :.:    |.:|:|.||...|..:.             ||.|...|:...|.|..:.|   .|...
Human   356 NGL----RQAPSSYPPTWPPGPAH-------------HSCHQSNSNGHRLCPTHVYA---APEGK 400

  Fly   296 SPLSFAAKMQSLSPVSVCSIGGETTSVVPVHPPTVSAQEGPMDLSMKTS---------RSSVHSF 351
            :|.:...:..|.:.:..|.:     ::.|......:.||...|.||..:         ...:..|
Human   401 APANSPRQGNSKNVLLACPM-----NMYPHGRSGRTVQEIWEDFSMSFTPAVREVVEFAKHIPGF 460

  Fly   352 NDSGSEDQ 359
            .|....||
Human   461 RDLSQHDQ 468

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kniNP_001287130.1 NR_DBD_like 8..92 CDD:413390 36/83 (43%)
NR1D1NP_068370.1 Modulating 1..128 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..119
Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000250|UniProtKB:Q3UV55 1..70
Crucial for activation of GJA1. /evidence=ECO:0000250 49..284 59/186 (32%)
NR_DBD_REV_ERB 127..215 CDD:143540 38/95 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 233..285 16/72 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 311..345 6/33 (18%)
NR_LBD 418..611 CDD:472173 11/56 (20%)
Blue background indicates that the domain is not in the aligned region.

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