Protein Alignment kni and esr2b

DIOPT Version :10

• Sequence 1: NP_001287130.1
• Gene: kni / 40287
• FlyBaseID: FBgn0001320
• Length: 434
• Species: Drosophila melanogaster
• Sequence 2: XP_005157029.1
• Gene: esr2b / 317733
• ZFINID: ZDB-GENE-030116-1
• Length: 600
• Species: Danio rerio
• Alignment Length: 514
• Identity: 111/514 - (21%)
• Similarity: 170/514 - (33%)
• Gaps: 198/514 - (38%)

  Fly    10 CKVCGEPAAGFHFGAFTCEGCKSFFGRS---YNNISTISECKNEGKCIIDKKNRTTCKACRLRKC 71
            |.||.:.|:|:|:|.::|||||:||.||   :|:..    |....:|.|||..|.:|:|||||||
Zfish   165 CAVCHDYASGYHYGVWSCEGCKAFFKRSIQGHNDYI----CPATNQCTIDKSRRKSCQACRLRKC 225

  Fly    72 YNVGMSKGGSRYGRRSNWFKIHCLLQEHEQAAAAAGKAPP----LAGGVSVGGAPSASSPVGSPH 132
            |.|||.|.|.:...|      .|:.:|......|..:..|    .:|||           ||.
Zfish   226 YEVGMMKCGMQLTLR------FCVRRERCSYRGARHRRNPQIRDSSGGV-----------VGL-- 271

  Fly   133 TPGFGDMAAHLHHHHQQQQQQQVPRHPHMPLLGYPSYLSDPSAALPFFSMMGGVP-----HQSPF 192
                         ..|.||..:.|..|...|  :||               ||..     :.||.
Zfish   272 -------------RGQSQQHLEFPLSPSQHL--FPS---------------GGRAEGRGLNYSPE 306

  Fly   193 QL--------PPHLLF------PGYHASAAAAAASAADAAYRQEMYKHRQSVDSVESQNRFSPAS 243
            ||        ||.:..      |...||...:..|.||
Zfish   307 QLVSCILEAEPPQIYLREPVKKPYTEASMMMSLTSLAD--------------------------- 344

  Fly   244 QPPVVQPTSSARQSP--IDVCLEEDVHSVHSHQSSASLL--------HPIAIRATPTTPTSSSP- 297
             ..:|...|.|::.|  :::.|.:.||.:........:|        ||..:..||....:...
Zfish   345 -KELVLMISWAKKIPGFVELTLSDQVHLLECCWLDILMLGLMWRSVDHPGKLIFTPDLKLNREEG 408

  Fly   298 -------------LSFAAKMQSLS---PVSVC-----SIGGETTSVVPVHPPTVSAQEGPMDLSM 341
                         |:..::.:.|.   ...||     .:.....|.:|..|..|.::...::|..
Zfish   409 NCVEGIMEIFDMLLATTSRFRELKLQREEYVCLKAMILLNSNNCSSLPQTPEDVESRGKVLNLLD 473

  Fly   342 KTSRSSVHSFNDSG--SEDQEVEVA----------------------PRRK----FYQLEAECLT 378
            ..:.:.|...:.:|  |:.|.:.:|                      .:||    .|.|..|.|.
Zfish   474 SVTDALVWIISRTGLSSQQQSIRLAHLLMLLSHIRHLSNKGIEHLSNMKRKNVVLLYDLLLEMLD 538

  Fly   379 TSSSSSS-------------HSA-------------AHSPN-----TTTAHAEVKRQKL 406
            .::|.||             |::             .|||.     ..|.|:.:.|:.:
Zfish   539 ANTSQSSRMLEDRQQSPENLHTSRPQPDLKDSDQETPHSPRAEETVNKTLHSSLLREDM 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kni	NP_001287130.1	NR_DBD_like	8..92	CDD:413390	38/84 (45%)
esr2b	XP_005157029.1	ERbeta_N	31..134	CDD:463610
		NR_DBD_ER	160..249	CDD:143545	40/93 (43%)
		NR_LBD_ER	304..527	CDD:132747	40/250 (16%)