Protein Alignment kni and Esr1

DIOPT Version :10

• Sequence 1: NP_001287130.1
• Gene: kni / 40287
• FlyBaseID: FBgn0001320
• Length: 434
• Species: Drosophila melanogaster
• Sequence 2: XP_017444286.2
• Gene: Esr1 / 24890
• RGDID: 2581
• Length: 665
• Species: Rattus norvegicus
• Alignment Length: 496
• Identity: 119/496 - (23%)
• Similarity: 179/496 - (36%)
• Gaps: 145/496 - (29%)

  Fly     1 MVFNLMNQT--CKVCGEPAAGFHFGAFTCEGCKSFFGRS---YNNISTISECKNEGKCIIDKKNR 60
            |:.....:|  |.||.:.|:|:|:|.::|||||:||.||   :|:..    |....:|.|||..|
  Rat   212 MIMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYM----CPATNQCTIDKNRR 272

  Fly    61 TTCKACRLRKCYNVGMSKGGSRYGRRSNWFKIHCLLQEHEQAAAAAGKAPPLAGGVSVGGAPSAS 125
            .:|:||||||||.|||.|||.|..||..     .:|:...|.....|:......| .:..|....
  Rat   273 KSCQACRLRKCYEVGMMKGGIRKDRRGG-----RMLKHKRQRDDLEGRNEMGTSG-DMRAANLWP 331

  Fly   126 SPVGSPHT----PGFGDMAAHLHHHHQQQQQQQVPRHPHMPLLGYPSYLSDPSAALPFFSMMGGV 186
            ||:...||    |.....|       .|.....:...|  ||: |..|  |||......||||.:
  Rat   332 SPLVIKHTKKNSPALSLTA-------DQMVSALLDAEP--PLI-YSEY--DPSRPFSEASMMGLL 384

  Fly   187 PHQSPFQLPPHLL-----FPGY---------HASAAA------------AAASAADAAYRQEMYK 225
            .:.:..:| .|::     .||:         |....|            :........:...:..
  Rat   385 TNLADREL-VHMINWAKRVPGFGDLNLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLL 448

  Fly   226 HRQSVDSVE--------SQNRFSPASQPP-------------------VVQPTSSA-----RQSP 258
            .|..:..::        |:..|:|.::.|                   ::..|||.     .|..
  Rat   449 DRDIISGLQILLVSLDFSERTFNPLTKCPFSSLRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGE 513

  Fly   259 IDVCLEEDV---HSVHSHQSSA--SL-----LHPIAIRATPTTPTSSSPLSFAAKMQS------- 306
            ..|||:..:   ..|::..||.  ||     :|.:..:.|.|.....:......:.|.
  Rat   514 EFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHRRLAQLL 578

  Fly   307 --LSPVSVCSIGG-------ETTSVVPVHPPTVSAQEGPMDLSMKTSRSSVHSFNDSGSEDQEVE 362
              ||.:...|..|       :..:|||::...:...:... |....||..|.....|.|:
  Rat   579 LILSHIRHMSNKGMEHLYNMKCKNVVPLYDLLLEMLDAHR-LHAPASRMGVPPEEPSQSQ----- 637

  Fly   363 VAPRRKFYQLEAECLTTSSSSSSHS---------AAHSPNT 394
                          |||:||:|:||         |...|||
  Rat   638 --------------LTTTSSTSAHSLQTYYIPPEAEGFPNT 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kni	NP_001287130.1	NR_DBD_like	8..92	CDD:413390	42/88 (48%)
Esr1	XP_017444286.2	Oest_recep	75..219	CDD:460469	1/6 (17%)
		NR_DBD_ER	218..299	CDD:143545	41/84 (49%)
		NR_LBD_ER	348..617	CDD:132747	48/281 (17%)
		ESR1_C	622..665	CDD:432757	17/62 (27%)