DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kni and nhr-23

DIOPT Version :9

Sequence 1:	NP_001287130.1	Gene:	kni / 40287	FlyBaseID:	FBgn0001320	Length:	434	Species:	Drosophila melanogaster
Sequence 2:	NP_001020975.1	Gene:	nhr-23 / 172460	WormBaseID:	WBGene00003622	Length:	588	Species:	Caenorhabditis elegans

Alignment Length:	410	Identity:	97/410 - (23%)
Similarity:	149/410 - (36%)	Gaps:	143/410 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 CKVCGEPAAGFHFGAFTCEGCKSFFGRSYNNISTISECKNEGKCIIDKKNRTTCKACRLRKCYNV 74
            |||||:.::|.|:|..||||||.||.||.::|... :|..:..|::|:.||..|:.|||:||..:
Worm   163 CKVCGDKSSGVHYGVITCEGCKGFFRRSQSSIVNY-QCPRQKNCVVDRVNRNRCQYCRLKKCIEL 226

  Fly    75 GMSKGGSRYGRRS--NWFKIHCLLQEHEQAAA-------------------------------AA 106
            |||:...::||.|  ...|:...::.|::.||                               .:
Worm   227 GMSRDAVKFGRMSKKQREKVEDEVRMHKELAANGLGYQAIYGDYSPPPSHPSYCFDQSMYGHYPS 291

  Fly   107 GKAPPLAG-GVSVGGAPSASSPVG-------------------------SPHTPGFGDMAAHLHH 145
            |.:.|:.| .::|...|:...|..                         ||..|. .|:|..:..
Worm   292 GTSTPVNGYSIAVAATPTTPMPQNMYGATPSSTNGTQYVAHQATGGSFPSPQVPE-EDVATRVIR 355

  Fly   146 HHQQQQQQQVPRH----------PHM--------------PLLGYPSYLSDPSAALPFFSMMGG- 185
            ...||......:|          ||:              ||:         .|.:.|...:.|
Worm   356 AFNQQHSSYTTQHGVCNVDPDCIPHLSRAGGWELFARELNPLI---------QAIIEFAKSIDGF 411

  Fly   186 --VPHQSPFQLPPHLLFPGYHASAAAAAASAADAAYRQEMYKHRQSV--------DSVESQNRFS 240
              :|.::..||....:|.  .:...||.....||   |.:...|.||        |..|.|
Worm   412 MNLPQETQIQLLKGSVFE--LSLVFAAMYYNVDA---QAVCGERYSVPFACLIAEDDAEMQ---- 467

  Fly   241 PASQPPVVQPTSSARQSPIDVCLEEDVHSVHSHQSSASLL------------HPIAIRATPTTPT 293
                 .:|:         ::..|:|.|| :..|||..:||            |.|.|..|.|..|
Worm   468 -----LIVE---------VNNTLQEIVH-LQPHQSELALLAAGLILEQVSSSHGIGILDTATIAT 517

  Fly   294 SSSPLSFAAKMQSLSPVSVC 313
            :.:..:  |..||:.|...|
Worm   518 AETLKN--ALYQSVMPRIGC 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kni	NP_001287130.1	NR_DBD_like	8..92	CDD:295381	36/83 (43%)
nhr-23	NP_001020975.1	NR_DBD_ROR	156..250	CDD:143526	37/87 (43%)
nhr-23	NP_001020975.1	NR_LBD	384..580	CDD:299703	41/187 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5442
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860