Protein Alignment kni and Esr1

DIOPT Version :10

• Sequence 1: NP_001287130.1
• Gene: kni / 40287
• FlyBaseID: FBgn0001320
• Length: 434
• Species: Drosophila melanogaster
• Sequence 2: NP_031982.1
• Gene: Esr1 / 13982
• MGIID: 1352467
• Length: 599
• Species: Mus musculus
• Alignment Length: 217
• Identity: 71/217 - (32%)
• Similarity: 100/217 - (46%)
• Gaps: 37/217 - (17%)

  Fly     1 MVFNLMNQT--CKVCGEPAAGFHFGAFTCEGCKSFFGRS---YNNISTISECKNEGKCIIDKKNR 60
            |:.....:|  |.||.:.|:|:|:|.::|||||:||.||   :|:..    |....:|.|||..|
Mouse   178 MIMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYM----CPATNQCTIDKNRR 238

  Fly    61 TTCKACRLRKCYNVGMSKGGSRYGRRSNWFKIHCLLQEHEQAAAAAGKAPPLAGGVSVGGAPSAS 125
            .:|:||||||||.|||.|||.|..||..     .:|:...|.....|:....|.| .:..|....
Mouse   239 KSCQACRLRKCYEVGMMKGGIRKDRRGG-----RMLKHKRQRDDLEGRNEMGASG-DMRAANLWP 297

  Fly   126 SPVGSPHT----PGFGDMAAHLHHHHQQQQQQQVPRHPHMPLLGYPSYLSDPSAALPFFSMMGGV 186
            ||:...||    |.....|       .|.....:...|  |:: |..|  |||......||||.:
Mouse   298 SPLVIKHTKKNSPALSLTA-------DQMVSALLDAEP--PMI-YSEY--DPSRPFSEASMMGLL 350

  Fly   187 PHQSPFQLPPHLL-----FPGY 203
            .:.:..:| .|::     .||:
Mouse   351 TNLADREL-VHMINWAKRVPGF 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kni	NP_001287130.1	NR_DBD_like	8..92	CDD:413390	42/88 (48%)
Esr1	NP_031982.1	Modulating (transactivation AF-1), mediates interaction with MACROD1. /evidence=ECO:0000250	1..188		2/9 (22%)
		Interaction with DDX5, self-association. /evidence=ECO:0000250	35..178		71/217 (33%)
		Required for interaction with NCOA1. /evidence=ECO:0000250	35..47
		Oest_recep	42..185	CDD:460469	1/6 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	147..175
		NR_DBD_ER	184..265	CDD:143545	41/84 (49%)
		Mediates interaction with DNTTIP2. /evidence=ECO:0000250	189..314		52/134 (39%)
		Hinge	255..314		17/64 (27%)
		Interaction with AKAP13. /evidence=ECO:0000250	266..599		28/125 (22%)
		Self-association. /evidence=ECO:0000250	268..599		28/118 (24%)
		NR_LBD_ER	314..551	CDD:132747	17/71 (24%)
		Transactivation AF-2. /evidence=ECO:0000250	315..599		17/70 (24%)
		ESR1_C	556..599	CDD:432757
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	557..581