Protein Alignment kni and Nr3c2

DIOPT Version :10

• Sequence 1: NP_001287130.1
• Gene: kni / 40287
• FlyBaseID: FBgn0001320
• Length: 434
• Species: Drosophila melanogaster
• Sequence 2: NP_001077375.1
• Gene: Nr3c2 / 110784
• MGIID: 99459
• Length: 980
• Species: Mus musculus
• Alignment Length: 220
• Identity: 59/220 - (26%)
• Similarity: 81/220 - (36%)
• Gaps: 72/220 - (32%)

  Fly     7 NQTCKVCGEPAAGFHFGAFTCEGCKSFFGRS----YNNISTISECKNEGKCIIDKKNRTTCKACR 67
            ::.|.|||:.|:|.|:|..||..||.||.|:    :|.:     |.....|||||..|..|.|||
Mouse   600 SKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYL-----CAGRNDCIIDKIRRKNCPACR 659

  Fly    68 LRKCYNVGMSKGGSRYGRRSNWFKIHCLLQEHEQAAAAAGKAPPLAGGVSVGGAPSASSPVGSPH 132
            |:||...||:.|    .|:|.                ..||...|
Mouse   660 LQKCLQAGMNLG----ARKSK----------------KLGKLKGL-------------------- 684

  Fly   133 TPGFGDMAAHLHHHHQQQQQQQVPRHPHMPLLG--YPSYLSDP---SAALPFFSMMGGVPHQSPF 192
                          |::|.||..|..|..|..|  |.:...:|   ||.:|..:.:......||.
Mouse   685 --------------HEEQPQQPPPPPPQSPEEGTTYIAPTKEPSVNSALVPQLASITRALTPSPS 735

  Fly   193 ----QLPPHLLFPGYHASAAAAAAS 213
                .:.|.:::.||..|....|.|
Mouse   736 MILENIEPEIVYAGYDNSKPDTAES 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kni	NP_001287130.1	NR_DBD_like	8..92	CDD:413390	35/87 (40%)
Nr3c2	NP_001077375.1	Modulating	1..602		0/1 (0%)
		Herpes_BLLF1	<200..>394	CDD:282904
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	234..331
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	353..372
		NR_DBD_GR_PR	599..673	CDD:143546	33/81 (41%)
		Hinge	669..721		18/105 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	683..708		10/58 (17%)
		NR_LBD_MR	733..980	CDD:132760	8/28 (29%)
		Important for coactivator binding. /evidence=ECO:0000250	778..781