Protein Alignment Rcd2 and VWF

DIOPT Version :10

• Sequence 1: NP_649244.3
• Gene: Rcd2 / 40283
• FlyBaseID: FBgn0037012
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: NP_000543.3
• Gene: VWF / 7450
• HGNCID: 12726
• Length: 2813
• Species: Homo sapiens
• Alignment Length: 434
• Identity: 81/434 - (18%)
• Similarity: 134/434 - (30%)
• Gaps: 182/434 - (41%)

  Fly     7 ICLLLRILQSCAMPIIDPDSIDESLACPP------CENDFPICYKVIVEVERGNGLPGSCCPRYE 65
            :|:..|....|||            :|||      ||:.                     |||:
Human  2189 VCVDWRTPDFCAM------------SCPPSLVYNHCEHG---------------------CPRH- 2219

  Fly    66 CLDEEPVCDGSKRRFYKNKCTVCDPCEPLAIQCKEICPMEEPEPICLSDNNEYHRNGDIWMENN- 129
                   |||:......:....|. |.|..:..:..|..||....|:.::...|:..:.|:.::
Human  2220 -------CDGNVSSCGDHPSEGCF-CPPDKVMLEGSCVPEEACTQCIGEDGVQHQFLEAWVPDHQ 2276

  Fly   130 -------------GCT----------TC-MCEGGYVTRNAVQCNHYYRC---------------- 154
                         .||          || :||...:.:||.||...|.|
Human  2277 PCQICTCLSGRKVNCTTQPCPTAKAPTCGLCEVARLRQNADQCCPEYECVCDPVSCDLPPVPHCE 2341

  Fly   155 -------NNPVEV---------KGQC-------CP----------VCPDELGVSNSIYDDGNHKY 186
                   .||.|.         |.:|       ||          .|.||       |:...:..
Human  2342 RGLQPTLTNPGECRPNFTCACRKEECKRVSPPSCPPHRLPTLRKTQCCDE-------YECACNCV 2399

  Fly   187 RNTTSAPI--LGESESSSSGWSST--VP--------------------------TDTSDS----- 216
            .:|.|.|:  |..:.::..|.::|  :|                          ||..|:
Human  2400 NSTVSCPLGYLASTATNDCGCTTTTCLPDKVCVHRSTIYPVGQFWEEGCDVCTCTDMEDAVMGLR 2464

  Fly   217 VPDTSGSPNSSSTSSEL----------ATPTPNTSELSSSTERTSTDSSYEQLG-EFATSESPDL 270
            |...|..|...|..|..          ....|:..|:.:.:.|..:.||::.:| ::|:.|:|.|
Human  2465 VAQCSQKPCEDSCRSGFTYVLHEGECCGRCLPSACEVVTGSPRGDSQSSWKSVGSQWASPENPCL 2529

  Fly   271 RTD----SEE---QETSSSDSAMETTTNPTTFEATATSTVSSTS 307
            ..:    .||   |:.:.|...:|....|:.|:.:..::....|
Human  2530 INECVRVKEEVFIQQRNVSCPQLEVPVCPSGFQLSCKTSACCPS 2573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rcd2	NP_649244.3	VWC	114..168	CDD:214564	21/127 (17%)
VWF	NP_000543.3	VWD	35..179	CDD:459671
		C8	222..291	CDD:214843
		TIL	295..348	CDD:410995
		VWC	350..>394	CDD:450195
		VWD	388..541	CDD:459671
		C8	579..648	CDD:214843
		TIL	652..707	CDD:410995
		Amino-terminal	764..787
		E1	788..833
		TIL	<788..827	CDD:410995
		CX	826..853
		VWD	856..1011	CDD:214566
		C8	1053..1127	CDD:214843
		TIL	1146..1196	CDD:410995
		VWA_N2	1198..1276	CDD:465038
		VWA	1277..1449	CDD:214621
		VWA	1498..1658	CDD:459670
		VWA	1691..1862	CDD:459670
		VWD	1950..2102	CDD:459671
		C8	2135..2200	CDD:214843	2/10 (20%)
		TIL	2203..2254	CDD:410995	17/80 (21%)
		E2	2216..2261		13/53 (25%)
		VWC	2261..2321	CDD:214564	12/59 (20%)
		VWC	2431..2494	CDD:214564	8/62 (13%)
		Cell attachment site	2507..2509		1/1 (100%)
		VWC	2582..2644	CDD:278520
		CT	2727..2808	CDD:214482