Protein Alignment Rcd2 and OTOG

DIOPT Version :10

• Sequence 1: NP_649244.3
• Gene: Rcd2 / 40283
• FlyBaseID: FBgn0037012
• Length: 452
• Species: Drosophila melanogaster
• Sequence 2: NP_001264198.1
• Gene: OTOG / 340990
• HGNCID: 8516
• Length: 2925
• Species: Homo sapiens
• Alignment Length: 315
• Identity: 73/315 - (23%)
• Similarity: 107/315 - (33%)
• Gaps: 63/315 - (20%)

  Fly   112 LSDNNEYHRNGDIW----MENNGCTTCMCEGGYVTRNAVQCNHYYRCNNP--------VEVKGQC 164
            |.::.|..|.|.::    .:.:|....:||..|   :|.....:..|.:|        ..|:| |
Human  1381 LYEHTEVFRRGTLFRLLDAKPSGAAYPICEWRY---DACASPCFQTCRDPRAASCRDVPRVEG-C 1441

  Fly   165 CPVCP-----DELGVSNSIY-DD-------------GNHKYRNTTSAPILGESESSSSGWSSTVP 210
            .||||     ||: ....:| :|             ||.....:...|...:.|...|..|...|
Human  1442 VPVCPTPQVLDEV-TQRCVYLEDCVEPAVWVPTEALGNETLPPSQGLPTPSDEEPQLSQESPRTP 1505

  Fly   211 TDTSDSVP----DTSGSPNSSSTSSELATPTPNTSELSSSTERTSTD------SSYEQLGEFA-- 263
            |......|    .|:.:|..::|...:.:|.|..:.|....|.|::.      .|....|..|
Human  1506 THRPALTPAAPLTTALNPPVTATEEPVVSPGPTQTTLQQPLELTASQLPAGPTESPASKGVTASL 1570

  Fly   264 -----TSESPDLRTDSEEQETSSSDSAMETTTNPTTFEATATSTVSSTSMELPTATDDGITK-MD 322
                 |.||..|....:.........|||||.....|..:...||||.|.  |......:|| :.
Human  1571 LAIPHTPESSSLPVALQTPTPGMVSGAMETTRVTVIFAGSPNITVSSRSP--PAPRFPLMTKAVT 1633

  Fly   323 FNPDGRTPKATDEPTVILVNATNFLSVVTDNPITNQP-------AVVAPESTSQI 370
            ....|..|..|..|...|..:.:...|.:...|:..|       ||:.|..|..|
Human  1634 VRGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVLTPAVTKVI 1688

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rcd2	NP_649244.3	VWC	114..168	CDD:214564	14/65 (22%)
OTOG	NP_001264198.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	39..69
		VWD	152..302	CDD:459671
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	316..335
		C8	349..412	CDD:462584
		TIL	426..474	CDD:460351
		VWC_out	476..>511	CDD:214565
		VWD	514..669	CDD:459671
		C8	713..767	CDD:462584
		TIL	780..844	CDD:410995
		TIL	884..946	CDD:410995
		VWD	977..1131	CDD:214566
		C8	1166..1240	CDD:214843
		beta-trefoil_ABD_OTOG	1245..1396	CDD:467810	4/14 (29%)
		PHA03247	<1476..2041	CDD:223021	51/215 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1476..1540		14/63 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1636..1679		8/42 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1693..1715
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1737..1788
		VWD	2112..2266	CDD:459671
		C8	2304..2370	CDD:214843
		TIL	2373..2434	CDD:460351
		Rossmann-fold NAD(P)(+)-binding proteins	<2676..2736	CDD:473865
		CT	2842..2924	CDD:214482