Protein Alignment Pss and PTDSS2

DIOPT Version :10

• Sequence 1: NP_649242.1
• Gene: Pss / 40281
• FlyBaseID: FBgn0287585
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_001316473.1
• Gene: PTDSS2 / 81490
• HGNCID: 15463
• Length: 503
• Species: Homo sapiens
• Alignment Length: 484
• Identity: 159/484 - (32%)
• Similarity: 236/484 - (48%)
• Gaps: 70/484 - (14%)

  Fly    26 AGDAERDHPAYKSGAASAPATPTKRRDG-SDGSVSSAG-ARRKRKDEIAQTFVIVNERPVDDISL 88
            ||....:.|. .:|.||....|    || |.|..:..| .||..:.|:           .||.:.
Human     9 AGGPRPESPV-PAGRASLEEPP----DGPSAGQATGPGEGRRSTESEV-----------YDDGTN 57

  Fly    89 DFFYKPHTITLLAVSVLAVMYFAFVRNEANVDE--NLWAGLLCIVFFFLIVSVIAFPNGPFTRPH 151
            .||::.||:|:|.:....:.|...: .|...|.  |...|::..:..||...|....:|||:|||
Human    58 TFFWRAHTLTVLFILTCTLGYVTLL-EETPQDTAYNTKRGIVASILVFLCFGVTQAKDGPFSRPH 121

  Fly   152 PAVWRILFGCSVLYLLTLQFLMFQNYP-------------TI---RSIFYWIDPKLKNFHIDM-E 199
            ||.||.....||:|.|.|.|::||..|             |:   |....::||||   .:.: |
Human   122 PAYWRFWLCVSVVYELFLIFILFQLPPLTVAPLTGALALQTVQDGRQFLKYVDPKL---GVPLPE 183

  Fly   200 KEYGVNCSDIS-----------WDRVKGHLDVFAWGHFLGWAFKAILIRHMGILWAISVMWEITE 253
            ::||.||....           ||:    ||.|...|||||..|.::||...:...||||:|..|
Human   184 RDYGGNCLIYDPDNETDPFHNIWDK----LDGFVPAHFLGWYLKTLMIRDWWMCMIISVMFEFLE 244

  Fly   254 ITFAHLLPNFIECWWDALILDVIICNGLGIWMGLKICQILEMREYKWASIKDISTTTGKIKRAML 318
            .:..|.||||.|||||..|:||::||||||:.|:|..:.|.::.|||..:.:|.|..||:||...
Human   245 YSLEHQLPNFSECWWDHWIMDVLVCNGLGIYCGMKTLEWLSLKTYKWQGLWNIPTYKGKMKRIAF 309

  Fly   319 QFTPESWSAIRWLDPKSTAMRFAAVIQLVIFWQVTELNTFFLKHIFEMPPDHFIVIGRLIFIGLF 383
            ||||.||....| .|.|:..|:.||..:::.:.:.|||||:||.:..|||:|::|:.||:|....
Human   310 QFTPYSWVRFEW-KPASSLRRWLAVCGIILVFLLAELNTFYLKFVLWMPPEHYLVLLRLVFFVNV 373

  Fly   384 VAPSVRQYYVYVTDTR-CKRVGTQCWVYGAIMVSEAILCIKNGKE--------LFERTQAINIVL 439
            ...::|:.|.::.|.: .|::|.|.|:..||..:|.::.:|....        ...:...:..||
Human   374 GGVAMREIYDFMDDPKPHKKLGPQAWLVAAITATELLIVVKYDPHTLTLSLPFYISQCWTLGSVL 438

  Fly   440 WLTVQV----IISVAFVYLAVYWQQRQLK 464
            .||..|    :..:...|....||:.|.|
Human   439 ALTWTVWRFFLRDITLRYKETRWQKWQNK 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pss	NP_649242.1	PSS	150..425	CDD:460783	114/303 (38%)
PTDSS2	NP_001316473.1	PSS	120..416	CDD:460783	114/303 (38%)