DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5078 and ATR2

DIOPT Version :9

Sequence 1:	NP_649238.3	Gene:	CG5078 / 40276	FlyBaseID:	FBgn0037005	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_014006.1	Gene:	ATR2 / 855322	SGDID:	S000004892	Length:	540	Species:	Saccharomyces cerevisiae

Alignment Length:	522	Identity:	98/522 - (18%)
Similarity:	164/522 - (31%)	Gaps:	213/522 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 AWGLLTMPMIATLKETFPDHTFLMNGLVMGVKGILSFLSSPLIGALSDIYGRKVLLLITVIFTSL 101
            ||.:.:.|:.|        .:|::                 :.|.|.||||.|.:|::..:..
Yeast   109 AWLMASFPLAA--------GSFIL-----------------ISGRLGDIYGLKKMLIVGYVIV-- 146

  Fly   102 PIPMMTMDNWWFFVISSISGVLGVSFSVAFAYVADVTTKEERSRSYELVSATFAASLVIAPAMGN 166
                        .|.|.|||:...|.|.||...         ||:::.|...|     |.|.:..
Yeast   147 ------------IVWSIISGLSKYSNSDAFFIT---------SRAFQGVGIAF-----ILPNIMG 185

  Fly   167 LIMDRYGI-----NTVVLVATLVSTTNVMF------------------------------VLLA- 195
            |:...|.:     |.|:......:.|..||                              :|:|
Yeast   186 LVGHVYKVGSFRKNIVISFIGACAPTGGMFGGLFGGLIVTEDPNQWPWVFYAFGIATFLSLLMAW 250

  Fly   196 --VPETLQQNVRSTGLS-------------------WKQADPFLSLRRVGSD-PNVLLLCVVMFT 238
              :|..:..|:.  |||                   |.|| |.     ||.| |.:::|.::...
Yeast   251 YSIPNNVPTNIH--GLSMDWTGSALAIIGLILFNFVWNQA-PI-----VGWDKPYIIVLLIISVI 307

  Fly   239 FLLP---EAGEYSSVPA-------------------------------YLKLTMG---------- 259
            ||:.   ...:|:.||.                               |:...:.
Yeast   308 FLVAFFVYESKYAEVPLLPRAMTKNRHMIMILLAVFLGWGSFGIWTFYYVSFQLNLRHYSPVWTG 372

  Fly   260 ---FDFTELSTLVAFMAILGISINVTLGSIVKTLGAKNAIILGLLLELLQLILFAI-----GYEK 316
               |.|....::.||.....|          |.||....:...|:......|:|::     .|.|
Yeast   373 GTYFVFVIFGSMAAFFVAFSI----------KRLGPALLLCFSLMAFDAGSIMFSVLPVEQSYWK 427

  Fly   317 WQMWLAGNVAALSSITFPAVSAYVSLYTDVETQG----AVQGMITGMSGLCSGLGPALFGIVFYL 377
            ....:...:.....::|||.|..:|....::.||    .|..:|...:.||.|:|    |.|.:
Yeast   428 LNFAMQAILCFGMDLSFPASSIILSDGLPMQYQGMAGSLVNTVINYSASLCLGMG----GTVEH- 487

  Fly   378 SDMDLDKNRILIGSVSGDRTVTNPFMIGAISVFIGILLAS--------YIPDEKVSRGRREEFSA 434
             .::...|.:|.|.              ..:|::|:.|||        |:.:...:|.|:.|..:
Yeast   488 -QINKSGNDLLKGY--------------RAAVYLGVGLASLGVVISVTYMLENLWNRHRKSEDRS 537

  Fly   435 LK 436
            |:
Yeast   538 LE 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5078	NP_649238.3	MFS	27..375	CDD:119392	84/451 (19%)
CG5078	NP_649238.3	MFS_1	27..368	CDD:284993	82/444 (18%)
ATR2	NP_014006.1	MFS_Amf1_MDR_like	74..519	CDD:341029	93/500 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341862
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930