DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5078 and MFSD14B

DIOPT Version :9

Sequence 1:	NP_649238.3	Gene:	CG5078 / 40276	FlyBaseID:	FBgn0037005	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_115947.2	Gene:	MFSD14B / 84641	HGNCID:	23376	Length:	506	Species:	Homo sapiens

Alignment Length:	424	Identity:	214/424 - (50%)
Similarity:	290/424 - (68%)	Gaps:	19/424 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GIGKPSVGHILVVVFLEYFAWGLLTMPMIATLKETFPDHTFLMNGLVMGVKGILSFLSSPLIGAL 82
            |.|:|||.|..:|:|||:|||||||.||:..|.|||..||||||||:.||||:|||||:||||||
Human    39 GFGRPSVYHAAIVIFLEFFAWGLLTTPMLTVLHETFSQHTFLMNGLIQGVKGLLSFLSAPLIGAL 103

  Fly    83 SDIYGRKVLLLITVIFTSLPIPMMTMDNWWFFVISSISGVLGVSFSVAFAYVADVTTKEERSRSY 147
            ||::|||..||.||.||..|||:|.:..||:|.:.|:|||..|:|||.||||||||.:.|||.:|
Human   104 SDVWGRKPFLLGTVFFTCFPIPLMRISPWWYFAMISVSGVFSVTFSVIFAYVADVTQEHERSTAY 168

  Fly   148 ELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATLVSTTNVMFVLLAVPETLQQNVRSTG---- 208
            ..||||||||||.:||:|..:...||.:.||||||:|:..::.|:|:||||:|.:.:|...
Human   169 GWVSATFAASLVSSPAIGAYLSASYGDSLVVLVATVVALLDICFILVAVPESLPEKMRPVSWGAQ 233

  Fly   209 LSWKQADPFLSLRRVGSDPNVLLLCVVMFTFLLPEAGEYSSVPAYLKLTMGFDFTELSTLVAFMA 273
            :||||||||.||::||.|..|||:|:.:|...|||||:|||...||:..:||...:::..:|.:.
Human   234 ISWKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIAAFIAMVG 298

  Fly   274 ILGISINVT-LGSIVKTLGAKNAIILGLLLELLQLILFAIGYEKWQMWLAGNVAALSSITFPAVS 337
            ||.|..... |..::::||.||.::|||..::|||..:..|.:.|.||.||.|||:|||||||:|
Human   299 ILSIVAQTAFLSILMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSITFPAIS 363

  Fly   338 AYVSLYTDVETQGAVQGMITGMSGLCSGLGPALFGIVFYLSDMD-------LDKNRI-LIGSV-S 393
            |.||...:.:.||..||:|||:.|||:||||||:|.:||:..::       |:.|.: |.|:| .
Human   364 ALVSRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIFYMFHVELTELGPKLNSNNVPLQGAVIP 428

  Fly   394 GDRTVTNPFMIGAISVFIGILLASYIPDEKVSRG 427
            |.     ||:.||..|.:..|:|.:||:...:.|
Human   429 GP-----PFLFGACIVLMSFLVALFIPEYSKASG 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5078	NP_649238.3	MFS	27..375	CDD:119392	190/352 (54%)
CG5078	NP_649238.3	MFS_1	27..368	CDD:284993	185/345 (54%)
MFSD14B	NP_115947.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		MFS	48..450	CDD:119392	205/406 (50%)
		MFS_1	49..394	CDD:284993	185/344 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	457..481		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142527
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53596
OrthoDB	1	1.010	-	-		D139531at33208
OrthoFinder	1	1.000	-	-		FOG0001490
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102321
Panther	1	1.100	-	-	O	PTHR23504
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.720