DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5078 and mfsd14a2

DIOPT Version :9

Sequence 1:	NP_649238.3	Gene:	CG5078 / 40276	FlyBaseID:	FBgn0037005	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_955878.1	Gene:	mfsd14a2 / 322115	ZFINID:	ZDB-GENE-030131-834	Length:	493	Species:	Danio rerio

Alignment Length:	445	Identity:	228/445 - (51%)
Similarity:	306/445 - (68%)	Gaps:	42/445 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KKLLVSLAST-SGIGKPSVGHILVVVFLEYFAWGLLTMPMIATLKETFPDHTFLMNGLVMGVKGI 70
            ||:::....| .|||:|||.|.:||:|||:|||||||.||:|.|::|||.||||||||:.||||:
Zfish    19 KKIIIKDGGTPQGIGEPSVYHAVVVIFLEFFAWGLLTTPMLAVLRQTFPQHTFLMNGLIHGVKGL 83

  Fly    71 LSFLSSPLIGALSDIYGRKVLLLITVIFTSLPIPMMTMDNWWFFVISSISGVLGVSFSVAFAYVA 135
            |||||:||||||||::|||..||:||.||..|||:|.:..||:|.:.|:|||..|:|||.|||||
Zfish    84 LSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVISMSGVFAVTFSVIFAYVA 148

  Fly   136 DVTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATLVSTTNVMFVLLAVPETL 200
            |:|.:.|||.:|.|||||||||||.:||:|..:.:.||...||::||.::..::.|:|:||||:|
Zfish   149 DITQEHERSTAYGLVSATFAASLVTSPAIGAYLSEVYGDTLVVILATAIALLDICFILVAVPESL 213

  Fly   201 QQNVRSTG----LSWKQADPFLSLRRVGSDPNVLLLCVVMFTFLLPEAGEYSSVPAYLKLTMGFD 261
            .:.:|...    :||:|||||.|||:||.|..|||:|:.:|...|||||.|||...||:..:||
Zfish   214 PEKMRPASWGAPISWEQADPFASLRKVGQDSTVLLICITVFLSYLPEAGPYSSFFLYLRQVIGF- 277

  Fly   262 FTELSTLVAFMAILGI-SI---NVTLGSIVKTLGAKNAIILGLLLELLQLILFAIGYEKWQMWLA 322
              ...|:.||:|::|| ||   .|.||.:::::|.||.|:|||..::|||..:..|.:.|.||.|
Zfish   278 --TSETVAAFIAVVGILSILAQTVVLGILMRSIGNKNTILLGLGFQILQLAWYGFGSQPWMMWAA 340

  Fly   323 GNVAALSSITFPAVSAYVSLYTDVETQGAVQGMITGMSGLCSGLGPALFGIVFY-----LSDMD- 381
            |.|||:|||||||:||.||...|.:.||.|||||||:.|||:||||||:|.|||     ||:||
Zfish   341 GAVAAMSSITFPAISAIVSRNADPDQQGVVQGMITGIRGLCNGLGPALYGFVFYLFHVELSEMDP 405

  Fly   382 ---------------LDKNRILIGSVSGDRTVTNPFMIGAISVFIGILLASYIPD 421
                           .|::.|:.|.         ||:.||.||.:.:|:|.:||:
Zfish   406 AESPEKGVKPNMANPTDESAIIPGP---------PFLFGACSVLLSLLVALFIPE 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5078	NP_649238.3	MFS	27..375	CDD:119392	198/355 (56%)
CG5078	NP_649238.3	MFS_1	27..368	CDD:284993	193/348 (55%)
mfsd14a2	NP_955878.1	MFS	40..393	CDD:119392	198/355 (56%)
mfsd14a2	NP_955878.1	MFS_1	42..386	CDD:284993	193/346 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575218
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53596
OrthoDB	1	1.010	-	-		D139531at33208
OrthoFinder	1	1.000	-	-		FOG0001490
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102321
Panther	1	1.100	-	-	O	PTHR23504
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.720