DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5078 and Mfsd14a

DIOPT Version :9

Sequence 1:	NP_649238.3	Gene:	CG5078 / 40276	FlyBaseID:	FBgn0037005	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_032272.2	Gene:	Mfsd14a / 15247	MGIID:	1201609	Length:	490	Species:	Mus musculus

Alignment Length:	436	Identity:	222/436 - (50%)
Similarity:	300/436 - (68%)	Gaps:	25/436 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KKLLVSLAST-SGIGKPSVGHILVVVFLEYFAWGLLTMPMIATLKETFPDHTFLMNGLVMGVKGI 70
            ||:::....| .|||.|||.|.::|:|||:|||||||.|.:..|.||||.||||||||:.||||:
Mouse    19 KKIIIKDGGTPQGIGSPSVYHAVIVIFLEFFAWGLLTAPTLVVLHETFPKHTFLMNGLIQGVKGL 83

  Fly    71 LSFLSSPLIGALSDIYGRKVLLLITVIFTSLPIPMMTMDNWWFFVISSISGVLGVSFSVAFAYVA 135
            |||||:||||||||::|||..||:||.||..|||:|.:..||:|.:.|:|||..|:|||.|||||
Mouse    84 LSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVISVSGVFAVTFSVVFAYVA 148

  Fly   136 DVTTKEERSRSYELVSATFAASLVIAPAMGNLIMDRYGINTVVLVATLVSTTNVMFVLLAVPETL 200
            |:|.:.|||.:|.|||||||||||.:||:|..:...||.:.||::||.::..::.|:|:||||:|
Mouse   149 DITQEHERSMAYGLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESL 213

  Fly   201 QQNVRSTG----LSWKQADPFLSLRRVGSDPNVLLLCVVMFTFLLPEAGEYSSVPAYLKLTMGFD 261
            .:.:|...    :||:|||||.||::||.|..|||:|:.:|...|||||:|||...||:..|.|
Mouse   214 PEKMRPASWGAPISWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKF- 277

  Fly   262 FTELSTLVAFMAILGI-SI---NVTLGSIVKTLGAKNAIILGLLLELLQLILFAIGYEKWQMWLA 322
              ...::.||:|:||| ||   .:.|..:::::|.||.|:|||..::|||..:..|.|.|.||.|
Mouse   278 --SPESVAAFIAVLGILSIIAQTIVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAA 340

  Fly   323 GNVAALSSITFPAVSAYVSLYTDVETQGAVQGMITGMSGLCSGLGPALFGIVFYLSDMDLDKNRI 387
            |.|||:||||||||||.||...|.:.||.|||||||:.|||:||||||:|.:||:..::| |...
Mouse   341 GAVAAMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFHVEL-KELP 404

  Fly   388 LIGSVSGDRTVTN------------PFMIGAISVFIGILLASYIPD 421
            :.|:..|..|...            ||:.||.||.:.:|:|.:||:
Mouse   405 ITGTDLGTNTSPQHHFEQNSIIPGPPFLFGACSVLLALLVALFIPE 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5078	NP_649238.3	MFS	27..375	CDD:119392	195/355 (55%)
CG5078	NP_649238.3	MFS_1	27..368	CDD:284993	190/348 (55%)
Mfsd14a	NP_032272.2	MFS_MFSD14	37..449	CDD:340945	212/415 (51%)
Mfsd14a	NP_032272.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	466..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832364
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53596
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001490
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102321
Panther	1	1.100	-	-	O	PTHR23504
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.710