DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17637 and MFSD14A

DIOPT Version :9

Sequence 1:	NP_649237.1	Gene:	CG17637 / 40275	FlyBaseID:	FBgn0037004	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_149044.2	Gene:	MFSD14A / 64645	HGNCID:	23363	Length:	490	Species:	Homo sapiens

Alignment Length:	492	Identity:	170/492 - (34%)
Similarity:	256/492 - (52%)	Gaps:	90/492 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GIGKASVWHAVIVTFMHYFSWGLLTVPFIEKLSGSFGNRVLLVDGLVYGVRGILGFVTTPVMGAI 83
            |||..||:|||||.|:.:|:|||||.|.:..|..:|.....|::||:.||:|:|.|::.|::||:
Human    31 GIGSPSVYHAVIVIFLEFFAWGLLTAPTLVVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGAL 95

  Fly    84 SDFHGRKVVMLLAVATTYAPIPFMMLKSWWFFAILTVSSICGSTYSSSLAYVADTTTVENRSKGY 148
            ||..|||..:||.|..|.||||.|.:..||:||:::||.:...|:|...|||||.|....||..|
Human    96 SDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAY 160

  Fly   149 GFVAASFGAGIAFSPSLGNYLMKSYGSASVILIATITGMINILFIIFAVPESLVLKEKKVILNEN 213
            |.|:|:|.|.:..||::|.||.:.||.:.|:::||...:::|.||:.||||||
Human   161 GLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESL------------ 213

  Fly   214 NDNKVEDTKVDDISPKEKKENLNGEGKVNVEVNKPTSQNIVTNKELDQQFSKEENLQNDLTEKEK 278
                                         .|..:|.|.....:.|
Human   214 -----------------------------PEKMRPASWGAPISWE-------------------- 229

  Fly   279 IDNGSLNSSDLWEVLRKSRKDKNLLVIYLITFLSIWPFAGVDSTAPVYLKTNMGFEYEEVS---M 340
                   .:|.:..|:|..:|..:|:|.:..|||..|.||..|:..:||:..|.|..|.|:   .
Human   230 -------QADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPESVAAFIA 287

  Fly   341 MLGLLSVLAITSNILLGYIMNIVGAKWSIRLGLLLLFLQMLFFGFGTHHWMYWLSSILAALATII 405
            :||:||::|.|  |:|..:|..:|.|.:|.|||....||:.::|||:..||.|.:..:||:::|.
Human   288 VLGILSIIAQT--IVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSIT 350

  Fly   406 PAANNAVASIYASPDNRGAVLGIISGIECLSEGVGPAFFGLLFFIFQDD------SETDLKVN-S 463
            ..|.:|:.|..|..|.:|.|.|:|:||..|..|:|||.:|.:|:||..:      :.|||..| |
Human   351 FPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFHVELKELPITGTDLGTNTS 415

  Fly   464 P----------ISMPFVISAISVFVAIVLSSFIKKDT 490
            |          ...||:..|.||.:|::::.||.:.|
Human   416 PQHHFEQNSIIPGPPFLFGACSVLLALLVALFIPEHT 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17637	NP_649237.1	MFS	25..487	CDD:119392	164/481 (34%)
CG17637	NP_649237.1	MFS_1	30..441	CDD:284993	140/413 (34%)
MFSD14A	NP_149044.2	MFS_MFSD14	37..449	CDD:340945	164/481 (34%)
MFSD14A	NP_149044.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	465..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142516
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2848
OMA	1	1.010	-	-		QHG53596
OrthoDB	1	1.010	-	-		D139531at33208
OrthoFinder	1	1.000	-	-		FOG0001490
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23504
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.770