DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG17637 and Mfsd14b

DIOPT Version :9

Sequence 1:	NP_649237.1	Gene:	CG17637 / 40275	FlyBaseID:	FBgn0037004	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001100804.1	Gene:	Mfsd14b / 306687	RGDID:	1308377	Length:	507	Species:	Rattus norvegicus

Alignment Length:	487	Identity:	157/487 - (32%)
Similarity:	243/487 - (49%)	Gaps:	95/487 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GIGKASVWHAVIVTFMHYFSWGLLTVPFIEKLSGSFGNRVLLVDGLVYGVRGILGFVTTPVMGAI 83
            |.|:.||:||..|.|..:|:|||||.|.:..|..:|.....|::||:.||:|:|.|::.|::||:
  Rat    41 GFGQPSVYHAAFVIFFEFFAWGLLTTPMLTVLHETFPQHTFLMNGLIQGVKGLLSFLSAPLIGAL 105

  Fly    84 SDFHGRKVVMLLAVATTYAPIPFMMLKSWWFFAILTVSSICGSTYSSSLAYVADTTTVENRSKGY 148
            ||..|||..:|..|..|..|||.|.:..||:|.:::||.:...|:|...|||||.|....||..|
  Rat   106 SDVWGRKPFLLGTVFFTCFPIPLMRISPWWYFGMISVSGVFSVTFSVIFAYVADFTQEHERSTAY 170

  Fly   149 GFVAASFGAGIAFSPSLGNYLMKSYGSASVILIATITGMINILFIIFAVPESLVLKEKKVILNEN 213
            |:|:|:|.|.:..||::|.||..:||.:.|:|:||:..:::|.||:.||||||
  Rat   171 GWVSATFAASLVSSPAIGTYLSSNYGDSLVVLVATVVALLDICFILVAVPESL------------ 223

  Fly   214 NDNKVEDTKVDDISPKEKKENLNGEGKVNVEVNKPTSQNIVTNKELDQQFSKEENLQNDLTEKEK 278
                                                                          .||
  Rat   224 --------------------------------------------------------------PEK 226

  Fly   279 IDNGSLNSSDLWE------VLRKSRKDKNLLVIYLITFLSIWPFAGVDSTAPVYLKTNMGFEYEE 337
            |...|..:...|:      .|:|..||..:|:|.:..|||..|.||..|:..:||:..:||...:
  Rat   227 IRPASWGAQISWKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVK 291

  Fly   338 V---SMMLGLLSVLAITSNILLGYIMNIVGAKWSIRLGLLLLFLQMLFFGFGTHHWMYWLSSILA 399
            :   ..|:|:||:||.|  :.|..:|..:|.|.::.|||....||:.::|||...||.|.:..:|
  Rat   292 IVAFIAMVGILSILAQT--VFLSKLMRSLGNKNTVLLGLGFQILQLAWYGFGAQAWMMWAAGTVA 354

  Fly   400 ALATIIPAANNAVASIYASPDNRGAVLGIISGIECLSEGVGPAFFGLLFFIFQDD-SETDLKV-- 461
            |:::|...|.:|:.|..|..|.:|...|||:||..|..|:|||.:|.:|::|..: :|...|:
  Rat   355 AMSSITFPAVSALISRNAESDQQGVAQGIITGIRGLCNGLGPALYGFIFYLFHVELNELGPKLDS 419

  Fly   462 -NSPI------SMPFVISAISVFVAIVLSSFI 486
             |.|:      ..||:..|..|.::.:::.||
  Rat   420 DNDPLQGAFIPGPPFLFGACIVLMSFLVALFI 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG17637	NP_649237.1	MFS	25..487	CDD:119392	154/481 (32%)
CG17637	NP_649237.1	MFS_1	30..441	CDD:284993	135/419 (32%)
Mfsd14b	NP_001100804.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		MFS_MFSD14	47..452	CDD:340945	154/481 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	462..483
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336027
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53596
OrthoDB	1	1.010	-	-		D139531at33208
OrthoFinder	1	1.000	-	-		FOG0001490
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23504
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860