Protein Alignment CG18281 and VBA1

DIOPT Version :10

• Sequence 1: NP_649236.1
• Gene: CG18281 / 40274
• FlyBaseID: FBgn0037003
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_013806.1
• Gene: VBA1 / 855113
• SGDID: S000004694
• Length: 562
• Species: Saccharomyces cerevisiae
• Alignment Length: 511
• Identity: 98/511 - (19%)
• Similarity: 176/511 - (34%)
• Gaps: 149/511 - (29%)

  Fly    78 PVMGAISDFHGRKVVMLLA--------VATTYAPIPFMMLKSWWFFAILTVSSIC-----GSTYS 129
            |:.|.:||..|||..:|.|        :.|.:|       ::...|:|  ..:||     |....
Yeast    89 PLYGKLSDITGRKSALLTAQFFFGLGCLLTCFA-------RNVTEFSI--ARAICGIGAGGLNAI 144

  Fly   130 SSLAYVADTTTVENRSKGYGIVAASFGAGIAFSPSLGNYLMKSYG-------SASVILIAAITGL 187
            ||:| |:|..|...|....|.....||.|......||...:::.|       ...||::.::..:
Yeast   145 SSIA-VSDICTARERGVYQGYANIVFGFGQLLGAPLGGVFIETIGWRALFGIQVPVIMLCSVLAI 208

  Fly   188 INIMFIIFAVPESLVLKEKNNMLDEESDNKMEDINPKERKEILNREEKLNNHVSANKSNHGTSQN 252
            .||...:|.||                        |.:.:..|....:::  :..:.|...|...
Yeast   209 KNINIKLFHVP------------------------PMKERYTLKNLSRID--IFGSLSLVATISG 247

  Fly   253 LV------TNKELGQQFNKEENLQNDLTEK----EKIDNGSLNSSDLWEVLRKSRKDKNLLVIYL 307
            ::      .||.....|.....:...|.|:    |||..        :|:|.:|     ..:...
Yeast   248 VLFLCSSQLNKLYLALFTIGSFIVFILVERYYATEKILP--------FELLTRS-----FCLSSA 299

  Fly   308 ITFLSIWPFAGVDSTAPVYLKTNMGFEYEEVSMMLGLLSVLAITSNLLLGYI-----INIVGAKW 367
            :|.:|.:...|....:|:||:........:..:.|...|:.....:|:.|::     ||:....:
Yeast   300 VTVISSFVVFGEIFRSPIYLQLLQNISVTKTGLFLIFPSISVAVGSLVTGWVLRNTKINLAHCAY 364

  Fly   368 SIRLGLLLLLLQLFFFGFGTHHWMYWLSSILAALATIIPAANNAVASIYASPDNRGAVLGIISGI 432
            .|..|  .:::||...|.|     |:|.|                   :.:||.  .:..::..|
Yeast   365 QIIFG--GMIMQLLGLGLG-----YFLLS-------------------HLNPDY--TIYDMLESI 401

  Fly   433 ECLSEGVGPAFFGVLFFIFQDDSKNKVNSPISMPFVISAIGVFVAIVLTGFIKKETVEKAP---- 493
            ...|..:    :..|.::|       .:..:|..:....:...|:||.       ||||:.
Yeast   402 TFRSNSI----WWKLIYVF-------ASVLVSFGYACLLVATLVSIVF-------TVEKSQQGTM 448

  Fly   494 ----LIYKIIDDASEDEVEPLAKTTFKYEKN------NGYVKLEIDDNYDSDCKEH 539
                .:::.|.:     |...:.|...||.:      |...|.:.||.|....|::
Yeast   449 TGVFYLWRSIGN-----VLGASLTLVSYENSLSSMLWNYMFKTKRDDEYHFTKKQY 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18281	NP_649236.1	MFS	25..485	CDD:475125	83/441 (19%)
		235kDa-fam	<203..>299	CDD:130673	15/105 (14%)
VBA1	NP_013806.1	MFS_Azr1_MDR_like	42..469	CDD:341045	90/479 (19%)