Protein Alignment CG18281 and GEX2

DIOPT Version :10

• Sequence 1: NP_649236.1
• Gene: CG18281 / 40274
• FlyBaseID: FBgn0037003
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_013032.1
• Gene: GEX2 / 853981
• SGDID: S000001814
• Length: 615
• Species: Saccharomyces cerevisiae
• Alignment Length: 598
• Identity: 103/598 - (17%)
• Similarity: 195/598 - (32%)
• Gaps: 229/598 - (38%)

  Fly    49 KLSGSFGNRVLLVDGLVYGVRGIL--------------------GFVTTPVMGA--ISDFHGRKV 91
            :||..||...|.:...::.:.|.:                    |:|.|.::..  :|||...|.
Yeast   117 RLSDHFGRLRLFLVATIFYIMGTIIQSQATRLTMYAAGSVFYNCGYVGTNLLLTLILSDFSSLKW 181

  Fly    92 VMLLAVATTYAPIPFMMLKSWWFFAILTVSSICGSTYSSSLAYVADTTTVENRSKGYGIVAASFG 156
            .|            |....|:|.:.|:...|             .:..|..|..|.:
Yeast   182 RM------------FYQYASYWPYIIIPWIS-------------GNIITAANPQKNW-------- 213

  Fly   157 AGIAFSPSLGNYLMKSYGSASVILIAAITGL--INIMFIIFAVPESLVLKEKNNMLDEESDNKME 219
                              |.::.:.|.|..|  :.|:|:|      |.:|.|::...|     ..
Yeast   214 ------------------SWNIAMWAFIYPLSTLPIIFLI------LYMKYKSSKTAE-----WR 249

  Fly   220 DINPKERKEILNREEKLNNHVSANKSNHGTSQNLVTNKELGQQFNKEE----------------- 267
            .:..:.|||                ...|..:|||.      .|.|.:
Yeast   250 SLKEQARKE----------------RTGGLFENLVF------LFWKLDIVGILLITVSLGCILVP 292

  Fly   268 -NLQNDLTEK--------EKIDNGSLNSSDL-WEVLRKSRKDKNLLVIYLITFLSIWPFAGV--- 319
             .|.|:.::|        ..:..|.|....| ||.  |..|.. ||...|::...||...||
Yeast   293 LTLANETSQKWHNSKIIATLVSGGCLFFIFLYWEA--KFAKSP-LLPFKLLSDRGIWAPLGVTFF 354

  Fly   320 ---------DSTAPVYLKTNMGFEYEEVSMMLGLLSVLAITSNLLLGYII--------NIVG--A 365
                     |...||.| .:|.......:.::.|...:|.|::.....::        :::|  |
Yeast   355 NFFTFFISCDYLYPVLL-VSMKESSTSAARIVNLPDFVAATASPFYSLLVAKTRKLKLSVIGGCA 418

  Fly   366 KWSIRLGLLLLLLQLFFF----GFGTHHWMYWLSSILAALATIIPAANNAVASIYASPDNRGAVL 426
            .|.:.:||        |:    |.|:|..:. .:|::..|:.:: .:|:.:..:.|...:  :.:
Yeast   419 AWMVCMGL--------FYKYRGGSGSHEGVI-AASVIMGLSGLL-CSNSVIVILQAMTTH--SRM 471

  Fly   427 GIISGIEC----LSEGVGPAFFGVLFFIFQDDS--KNKVNSPI-----SMPF------------- 467
            .:|:||:.    |...:|.:..|.::.....:.  ||..|..:     :.|:
Yeast   472 AVITGIQYTFSKLGAAIGASVSGAIWTQTMPNQLYKNLGNDTLAEIAYASPYTFISDYPWGSPER 536

  Fly   468 ------------VISAIGVFVAI---VLTGFIKK-ETVEKAP--------LIYKIIDDASEDEVE 508
                        :|..:|:...:   ..|.|::. |.::||.        |:  ::.|  |:.:.
Yeast   537 DAVVESYRYVQRIIMTVGLACTVPFFTFTMFMRNPELIDKATHEEFTEDGLV--VLPD--EENIF 597

  Fly   509 PLAKTTFKYEKNN 521
            ...|..|::.::|
Yeast   598 SQIKALFRHNRSN 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18281	NP_649236.1	MFS	25..485	CDD:475125	94/551 (17%)
		235kDa-fam	<203..>299	CDD:130673	21/122 (17%)
GEX2	NP_013032.1	MFS_ARN_like	59..571	CDD:340880	94/553 (17%)