DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18281 and VBA5

DIOPT Version :9

Sequence 1:	NP_649236.1	Gene:	CG18281 / 40274	FlyBaseID:	FBgn0037003	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_013031.3	Gene:	VBA5 / 853980	SGDID:	S000001813	Length:	582	Species:	Saccharomyces cerevisiae

Alignment Length:	602	Identity:	114/602 - (18%)
Similarity:	194/602 - (32%)	Gaps:	215/602 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 FMHYFSWGLLTVPFIEKLSGSFGNRVLLVDGLVYG-VRGILGFVTTPVMGAISDFHGRKVVMLLA 96
            |.:|...|.|...:      |..|.:|   .|::| ...|:||..:.:: ||..|....::..||
Yeast    68 FGNYSKTGWLVTGY------SLPNAIL---SLIWGRFASIIGFQHSLIL-AILIFEAGSLIAALA 122

  Fly    97 VATTYAPIPFMMLKSWWFFAILTVSSICGSTYSSSLAYVADTTTVENRSKG--YGIVAASFGAGI 159
            .:..      |::    |..:  |:.:.||.. .:|.:|...|.|..||:.  ..|::.:|....
Yeast   123 SSMN------MLI----FGRV--VAGVGGSGL-QTLCFVIGCTMVGERSRPLVISILSCAFAVAA 174

  Fly   160 AFSPSLGN------------YLMKSYGSASVILIAAITGLINIMFIIFAVPESLVLKEKNNMLDE 212
            ...|.:|.            |:....|           ||..|||:       |..|.:|..:.:
Yeast   175 IVGPIIGGAFTTHVTWRWCFYINLPIG-----------GLAIIMFL-------LTYKAENKGILQ 221

  Fly   213 ESDNKMEDIN----PKERKEILNREEKLNNHV------------------------SANKSNHGT 249
            :..:.:..|:    .|.|.:: |.:..:|..:                        ..||.:..:
Yeast   222 QIKDAIGTISSFTFSKFRHQV-NFKRLMNGIIFKFDFFGFALCSAGLVLFLLGLTFGGNKYSWNS 285

  Fly   250 SQ--------------NLVTNKELGQQFNKEENLQNDLTEKEKIDNGSLNSSDLWEVLRKSRKDK 300
            .|              :||.:..|..:||.|.            ||.|....    :||:.....
Yeast   286 GQVITYLVLGVLLFIFSLVYDFFLFDKFNPEP------------DNISYRPL----LLRRLVAKP 334

  Fly   301 NLLVIYLITFL----------------------SIWPFAGVDSTAPVYLKTNMGFEYEEVSMMLG 343
            .::::.::|||                      |.|. ||:.....|............::..||
Yeast   335 AIIIVNMVTFLLCTGYNGQMIYSVQFFQLIFASSAWK-AGLHLIPIVITNVIAAIASGVITKKLG 398

  Fly   344 LLSVLAITSNLLLGYIINIVGAKWSIRLGLL--------------LLLLQLFFFGFGTHHWMYWL 394
            |:..|     |:.|.::.::||      ||:              :|||..|..||
Yeast   399 LVKPL-----LIFGGVLGVIGA------GLMTLMTNTSTKSTQIGVLLLPGFSLGF--------- 443

  Fly   395 SSILAALATIIPAANNAVASIYASPDNRGAVLGII--SGIECLSEGVGPAFFGVL-FFIFQDDSK 456
             ::.|:|.:         |.:..:.|...|.:..|  :......:.:|....||| ..:|.....
Yeast   444 -ALQASLMS---------AQLQITKDRPEAAMDFIEVTAFNTFMKSLGTTLGGVLSTTVFSASFH 498

  Fly   457 NKVNSPISMPF--------VI----------SAIG---------VF---VAIVLTGFIKKETVEK 491
            |||:.....|:        ::          |.||         ||   :.....||:.......
Yeast   499 NKVSRAHLEPYEGKTVDDMILYRLQNYDGSHSTIGNILSDSIKNVFWMDLGFYALGFLFCSFSSN 563

  Fly   492 APLIYKIIDDASEDEVE 508
            ..||....||..||.:|
Yeast   564 KKLIIPKKDDTPEDNLE 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18281	NP_649236.1	MFS	25..485	CDD:119392	107/577 (19%)
CG18281	NP_649236.1	MFS_1	30..441	CDD:284993	91/502 (18%)
VBA5	NP_013031.3	MFS_Azr1_MDR_like	43..493	CDD:341045	95/513 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341890
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930