Protein Alignment CG18281 and VBA5

DIOPT Version :10

• Sequence 1: NP_649236.1
• Gene: CG18281 / 40274
• FlyBaseID: FBgn0037003
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_013031.3
• Gene: VBA5 / 853980
• SGDID: S000001813
• Length: 582
• Species: Saccharomyces cerevisiae
• Alignment Length: 602
• Identity: 114/602 - (18%)
• Similarity: 194/602 - (32%)
• Gaps: 215/602 - (35%)

  Fly    33 FMHYFSWGLLTVPFIEKLSGSFGNRVLLVDGLVYG-VRGILGFVTTPVMGAISDFHGRKVVMLLA 96
            |.:|...|.|...:      |..|.:|   .|::| ...|:||..:.:: ||..|....::..||
Yeast    68 FGNYSKTGWLVTGY------SLPNAIL---SLIWGRFASIIGFQHSLIL-AILIFEAGSLIAALA 122

  Fly    97 VATTYAPIPFMMLKSWWFFAILTVSSICGSTYSSSLAYVADTTTVENRSKG--YGIVAASFGAGI 159
            .:..      |::    |..:  |:.:.||.. .:|.:|...|.|..||:.  ..|::.:|....
Yeast   123 SSMN------MLI----FGRV--VAGVGGSGL-QTLCFVIGCTMVGERSRPLVISILSCAFAVAA 174

  Fly   160 AFSPSLGN------------YLMKSYGSASVILIAAITGLINIMFIIFAVPESLVLKEKNNMLDE 212
            ...|.:|.            |:....|           ||..|||:       |..|.:|..:.:
Yeast   175 IVGPIIGGAFTTHVTWRWCFYINLPIG-----------GLAIIMFL-------LTYKAENKGILQ 221

  Fly   213 ESDNKMEDIN----PKERKEILNREEKLNNHV------------------------SANKSNHGT 249
            :..:.:..|:    .|.|.:: |.:..:|..:                        ..||.:..:
Yeast   222 QIKDAIGTISSFTFSKFRHQV-NFKRLMNGIIFKFDFFGFALCSAGLVLFLLGLTFGGNKYSWNS 285

  Fly   250 SQ--------------NLVTNKELGQQFNKEENLQNDLTEKEKIDNGSLNSSDLWEVLRKSRKDK 300
            .|              :||.:..|..:||.|.            ||.|....    :||:.....
Yeast   286 GQVITYLVLGVLLFIFSLVYDFFLFDKFNPEP------------DNISYRPL----LLRRLVAKP 334

  Fly   301 NLLVIYLITFL----------------------SIWPFAGVDSTAPVYLKTNMGFEYEEVSMMLG 343
            .::::.::|||                      |.|. ||:.....|............::..||
Yeast   335 AIIIVNMVTFLLCTGYNGQMIYSVQFFQLIFASSAWK-AGLHLIPIVITNVIAAIASGVITKKLG 398

  Fly   344 LLSVLAITSNLLLGYIINIVGAKWSIRLGLL--------------LLLLQLFFFGFGTHHWMYWL 394
            |:..|     |:.|.::.::||      ||:              :|||..|..||
Yeast   399 LVKPL-----LIFGGVLGVIGA------GLMTLMTNTSTKSTQIGVLLLPGFSLGF--------- 443

  Fly   395 SSILAALATIIPAANNAVASIYASPDNRGAVLGII--SGIECLSEGVGPAFFGVL-FFIFQDDSK 456
             ::.|:|.:         |.:..:.|...|.:..|  :......:.:|....||| ..:|.....
Yeast   444 -ALQASLMS---------AQLQITKDRPEAAMDFIEVTAFNTFMKSLGTTLGGVLSTTVFSASFH 498

  Fly   457 NKVNSPISMPF--------VI----------SAIG---------VF---VAIVLTGFIKKETVEK 491
            |||:.....|:        ::          |.||         ||   :.....||:.......
Yeast   499 NKVSRAHLEPYEGKTVDDMILYRLQNYDGSHSTIGNILSDSIKNVFWMDLGFYALGFLFCSFSSN 563

  Fly   492 APLIYKIIDDASEDEVE 508
            ..||....||..||.:|
Yeast   564 KKLIIPKKDDTPEDNLE 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18281	NP_649236.1	MFS	25..485	CDD:475125	107/577 (19%)
		235kDa-fam	<203..>299	CDD:130673	21/137 (15%)
VBA5	NP_013031.3	MFS_Azr1_MDR_like	43..493	CDD:341045	95/513 (19%)