DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18281 and Mfsd14b

DIOPT Version :9

Sequence 1:	NP_649236.1	Gene:	CG18281 / 40274	FlyBaseID:	FBgn0037003	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_001077370.1	Gene:	Mfsd14b / 66631	MGIID:	1913881	Length:	507	Species:	Mus musculus

Alignment Length:	530	Identity:	166/530 - (31%)
Similarity:	261/530 - (49%)	Gaps:	106/530 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GIGKASVWHAVIVTFMHYFSWGLLTVPFIEKLSGSFGNRVLLVDGLVYGVRGILGFVTTPVMGAI 83
            |.|..||:||..|.|:.:|:|||||.|.:..|..:|.....|::||:.||:|:|.|::.|::||:
Mouse    41 GFGHPSVYHAAFVIFLEFFAWGLLTTPMLTVLHETFPQHTFLMNGLIQGVKGLLSFLSAPLIGAL 105

  Fly    84 SDFHGRKVVMLLAVATTYAPIPFMMLKSWWFFAILTVSSICGSTYSSSLAYVADTTTVENRSKGY 148
            ||..|||..:|..|..|..|||.|.:..||:|.:::||.:...|:|...|||||.|....||..|
Mouse   106 SDVWGRKPFLLGTVFFTCFPIPLMRINPWWYFGMISVSGVFSVTFSVIFAYVADFTQEHERSTAY 170

  Fly   149 GIVAASFGAGIAFSPSLGNYLMKSYGSASVILIAAITGLINIMFIIFAVPESLVLKEKNNMLDEE 213
            |.|:|:|.|.:..||::|.||..:||.:.|:|:|.:..|::|.||:.||||||
Mouse   171 GWVSATFAASLVSSPAIGTYLSANYGDSLVVLVATLVALLDICFILIAVPESL------------ 223

  Fly   214 SDNKMEDINPKERKEILNREEKLNNHVSANKSNHGTSQNLVTNKELGQQFNKEENLQNDLTEKEK 278
                .|.|.|                                 ...|.|.
Mouse   224 ----SEKIRP---------------------------------ASWGAQI--------------- 236

  Fly   279 IDNGSLNSSDLWEVLRKSRKDKNLLVIYLITFLSIWPFAGVDSTAPVYLKTNMGFEYEEV---SM 340
                |...:|.:..|:|..||..:|:|.:..|||..|.||..|:..:||:..:||...::   ..
Mouse   237 ----SWKQADPFASLKKVGKDSTVLLICITVFLSYLPEAGQYSSFFLYLRQVIGFGSVKIVAFIA 297

  Fly   341 MLGLLSVLAITSNLLLGYIINIVGAKWSIRLGLLLLLLQLFFFGFGTHHWMYWLSSILAALATII 405
            |:|:||::|.|  :.|..::..:|.|.::.|||...:|||.::|||:..||.|.:..:||:::|.
Mouse   298 MVGILSIVAQT--VFLSKLMRSLGNKNTVLLGLGFQMLQLAWYGFGSQAWMMWAAGTVAAMSSIT 360

  Fly   406 PAANNAVASIYASPDNRGAVLGIISGIECLSEGVGPAFFGVLFFIFQDDSKN---KVNS---PI- 463
            ..|.:|:.|..|..|.:|...||::||..|..|:|||.:|.:|::|..:...   |:||   |:
Mouse   361 FPAVSALISRNAESDQQGVAQGIVTGIRGLCNGLGPALYGFIFYMFHVELSELGPKLNSDDDPLQ 425

  Fly   464 -----SMPFVISAIGVFVAIVLTGFI----KKETVEK-----------APLIYKIIDDASEDEVE 508
                 ..||:..|..|.::.::..||    |...|:|           .|      :..|::::|
Mouse   426 GAFIPGPPFLFGACIVLMSFLVALFIPEYRKTSGVQKHNNSTSGSLSTPP------ERGSDEDIE 484

  Fly   509 PLAKTTFKYE 518
            ||.:.:..:|
Mouse   485 PLLQDSSIWE 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18281	NP_649236.1	MFS	25..485	CDD:119392	154/478 (32%)
CG18281	NP_649236.1	MFS_1	30..441	CDD:284993	135/413 (33%)
Mfsd14b	NP_001077370.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		MFS_MFSD14	47..452	CDD:340945	153/474 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..483		4/29 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832376
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53596
OrthoDB	1	1.010	-	-		D139531at33208
OrthoFinder	1	1.000	-	-		FOG0001490
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23504
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.820