DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18281 and mfsd14a1

DIOPT Version :9

Sequence 1:	NP_649236.1	Gene:	CG18281 / 40274	FlyBaseID:	FBgn0037003	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_998692.2	Gene:	mfsd14a1 / 406848	ZFINID:	ZDB-GENE-040426-2935	Length:	485	Species:	Danio rerio

Alignment Length:	528	Identity:	173/528 - (32%)
Similarity:	255/528 - (48%)	Gaps:	129/528 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAQLKFLRPLVKVLVNRS----------------GIGKASVWHAVIVTFMHYFSWGLLTVPFIEK 49
            |.|.|      |..||||                |.|..||:|||||.|:.:|:|||||.|.:..
Zfish     1 MTQKK------KKRVNRSLLLAKKIIIKDGGTPQGFGSPSVYHAVIVIFLEFFAWGLLTAPTLGA 59

  Fly    50 LSGSFGNRVLLVDGLVYGVRGILGFVTTPVMGAISDFHGRKVVMLLAVATTYAPIPFMMLKSWWF 114
            |..:|.....|::||:.||:|:|.|::.|::||:||..|||..:||.|..|.||||.|.:..||:
Zfish    60 LDETFPKHTFLMNGLIQGVKGLLSFLSAPLIGALSDVWGRKSFLLLTVFFTCAPIPLMKISPWWY 124

  Fly   115 FAILTVSSICGSTYSSSLAYVADTTTVENRSKGYGIVAASFGAGIAFSPSLGNYLMKSYGSASVI 179
            ||:::||.:...|:|...|||||.|....||..||:|:|:|.|.:..||::|.||...||...|:
Zfish   125 FAMISVSGVFAVTFSVIFAYVADITQEHERSMAYGMVSATFAASLVISPAIGAYLSHVYGDTLVV 189

  Fly   180 LIAAITGLINIMFIIFAVPESLVLKEKNNMLDEESDNKMEDINPKERKEILNREEKLNNHVSANK 244
            ::|:...:::|.||:.||||||
Zfish   190 VLASAIAMLDICFILVAVPESL------------------------------------------- 211

  Fly   245 SNHGTSQNLVTNKELGQQFNKEENLQNDLTEKEKIDNGSLNSSDLWE------VLRKSRKDKNLL 303
                                           .||:...|..:...||      .|||..:|..:|
Zfish   212 -------------------------------PEKMRPASWGAPISWEQADPFASLRKVGQDSTVL 245

  Fly   304 VIYLITFLSIWPFAGVDSTAPVYLKTNMGFEYEEVS---MMLGLLSVLAITSNLLLGYIINIVGA 365
            :|.:..|||..|.||.:|:..:||:..|||..|.|:   .:||||||:|.|  ::|..::..:|.
Zfish   246 LICITVFLSYLPEAGQNSSFFLYLQQIMGFSSESVAAFIAVLGLLSVVAQT--VVLSLLMRSIGN 308

  Fly   366 KWSIRLGLLLLLLQLFFFGFGTHHWMYWLSSILAALATIIPAANNAVASIYASPDNRGAVLGIIS 430
            |.:|.|||...:|||.::|||:..||.|.:..:||:::|...|.:|:.|..|.||.:|...|:::
Zfish   309 KNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVAAMSSITFPAVSALISRTADPDQQGVGQGMVT 373

  Fly   431 GIECLSEGVGPAFFGVLFFIFQ---DDSKNK----------------VNSPISMPFVISAIGVFV 476
            ||..|..|:|||.:|.:|:||.   |....|                :..|   ||:..|..|.:
Zfish   374 GIRGLCNGLGPALYGFIFYIFHVELDKVPEKGPDVQHHRDLHQQSAIIPGP---PFLFGACSVLL 435

  Fly   477 AIVLTGFI 484
            |:::..||
Zfish   436 ALLVALFI 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18281	NP_649236.1	MFS	25..485	CDD:119392	162/488 (33%)
CG18281	NP_649236.1	MFS_1	30..441	CDD:284993	141/419 (34%)
mfsd14a1	NP_998692.2	MFS	38..395	CDD:119392	149/432 (34%)
mfsd14a1	NP_998692.2	MFS_1	40..384	CDD:284993	141/419 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575221
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53596
OrthoDB	1	1.010	-	-		D139531at33208
OrthoFinder	1	1.000	-	-		FOG0001490
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23504
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.820