DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18281 and CG8008

DIOPT Version :9

Sequence 1:	NP_649236.1	Gene:	CG18281 / 40274	FlyBaseID:	FBgn0037003	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_001137623.1	Gene:	CG8008 / 35935	FlyBaseID:	FBgn0033387	Length:	566	Species:	Drosophila melanogaster

Alignment Length:	567	Identity:	122/567 - (21%)
Similarity:	209/567 - (36%)	Gaps:	159/567 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 PFIEKLSGSFGNRVLLVDGLVYGVRGILGFVTTPVMGAISDFHGRKVVMLLAVATTYAPIPFMML 109
            |::..|   |..|.|| :.:|....|:.       :|:.||.:|||.::::::....|  .|:|:
  Fly    87 PYVANL---FLARTLL-ESIVPAFCGLF-------IGSWSDHYGRKPLLIVSMIGFSA--SFLMM 138

  Fly   110 KS------------WWFFAILTVSSICGSTYSSSLA---YVADTTTVENRSKGYGIVAASFGAGI 159
            .:            ||:.......|:.|.....|:|   :::|.|..::|......:.:.|..|:
  Fly   139 AAICELSSYYVVNPWWYIMAAVPHSLLGGNCVFSVAAFCFISDITDCKSRPYRMIFMESLFFIGL 203

  Fly   160 AFSPSLGNYLMKSYGSASVILIAAITGLINIMFIIFAVPESLVLKEKNNMLDEESDNKMEDINPK 224
            .....|.:::..:.|||:.|.|:........:||||.|||||...:     ::|:.|.   |...
  Fly   204 TSGSLLSSFVYAAVGSAATIGISGCIVTFATLFIIFFVPESLHFHK-----EQETKNA---ITAN 260

  Fly   225 ERKEILNREEKLN---------------NHVSANKSNHGTSQNLVTNKELGQQFNKE------EN 268
            ..||.::.:..:.               |.::..:........|.|.......|:.:      |.
  Fly   261 VEKECIDSKVPITACDLQLDRVAIDCPPNFMNDEEPGKDKRMELPTPATPAMSFDDDLLAKYVER 325

  Fly   269 LQNDLTEK------EKIDNGSLNS----SDLWEVLRKSRKDKNLLVIYLIT---FLSIWPFAGVD 320
            |.....|:      |:.....|.|    .|:.....|.|......:|:|:|   ||||:.|.||.
  Fly   326 LPQKAEERKRQEAEEQAKKAGLFSMVHIRDMISTCFKRRDHHARAIIWLVTLAMFLSIFVFDGVM 390

  Fly   321 STAPVYLKTNMGFE------YEEVSMMLGLLSVLAITSNLLLGYIINIVGAKWSIRLGLLLLLLQ 379
            :...::::....:.      :|.||.::.::..       |:|::|    .:...||.::.|.|.
  Fly   391 TVMYLFVREKFHWTVRDYTFFETVSHLVPMIGA-------LIGFLI----LRKVFRLSVVTLALL 444

  Fly   380 LFFF--------GFGTHHWMYWLSSILAALATIIPAANNAVASIYASPDNRGAVLGIISGIEC-- 434
            .||.        ||.|..|..:||..|                         .|...|||..|
  Fly   445 AFFSEILNNLAKGFATMPWHMYLSVTL-------------------------GVFRSISGPMCRT 484

  Fly   435 -LSEGVGPAFFGVLFFIFQDDSKNKVNSPISMPFVISAIGVFVAIVLTGFIKKETVEKAPLIYKI 498
             :|..|.|:..|.:|.|     ||          |:.:...|||..|...|.|.::...|.::..
  Fly   485 IVSNIVPPSDLGKIFSI-----KN----------VLQSFAPFVAAPLYTLIYKRSLTTYPGLFNF 534

  Fly   499 IDDASEDEVEPLAKTTFKYEKN---NGYVKLEIDDNYDSDCKEHSFK 542
            :             ::|.|..:   .||| |.|...|    |:|..|
  Fly   535 V-------------SSFLYLLSFVFIGYV-LRIKYRY----KQHYAK 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18281	NP_649236.1	MFS	25..485	CDD:119392	108/505 (21%)
CG18281	NP_649236.1	MFS_1	30..441	CDD:284993	97/461 (21%)
CG8008	NP_001137623.1	MFS	101..547	CDD:119392	107/526 (20%)
		MFS_1	101..>261	CDD:284993	40/176 (23%)
		MFS_1	375..>558	CDD:284993	56/251 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810