DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18281 and Mfsd14a

DIOPT Version :9

Sequence 1:	NP_649236.1	Gene:	CG18281 / 40274	FlyBaseID:	FBgn0037003	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_032272.2	Gene:	Mfsd14a / 15247	MGIID:	1201609	Length:	490	Species:	Mus musculus

Alignment Length:	498	Identity:	166/498 - (33%)
Similarity:	251/498 - (50%)	Gaps:	104/498 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GIGKASVWHAVIVTFMHYFSWGLLTVPFIEKLSGSFGNRVLLVDGLVYGVRGILGFVTTPVMGAI 83
            |||..||:|||||.|:.:|:|||||.|.:..|..:|.....|::||:.||:|:|.|::.|::||:
Mouse    31 GIGSPSVYHAVIVIFLEFFAWGLLTAPTLVVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGAL 95

  Fly    84 SDFHGRKVVMLLAVATTYAPIPFMMLKSWWFFAILTVSSICGSTYSSSLAYVADTTTVENRSKGY 148
            ||..|||..:||.|..|.||||.|.:..||:||:::||.:...|:|...|||||.|....||..|
Mouse    96 SDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAY 160

  Fly   149 GIVAASFGAGIAFSPSLGNYLMKSYGSASVILIAAITGLINIMFIIFAVPESLVLKEKNNMLDEE 213
            |:|:|:|.|.:..||::|.||.:.||.:.|:::|....|::|.||:.||||||
Mouse   161 GLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESL------------ 213

  Fly   214 SDNKMEDINPKERKEILNREEKLNNHVSANKSNHGTSQNLVTNKELGQQFNKEENLQNDLTEKEK 278
                                                                          .||
Mouse   214 --------------------------------------------------------------PEK 216

  Fly   279 IDNGSLNSSDLWE------VLRKSRKDKNLLVIYLITFLSIWPFAGVDSTAPVYLKTNMGFEYEE 337
            :...|..:...||      .|:|..:|..:|:|.:..|||..|.||..|:..:||:..|.|..|.
Mouse   217 MRPASWGAPISWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPES 281

  Fly   338 VS---MMLGLLSVLAITSNLLLGYIINIVGAKWSIRLGLLLLLLQLFFFGFGTHHWMYWLSSILA 399
            |:   .:||:||::|.|  ::|..::..:|.|.:|.|||...:|||.::|||:..||.|.:..:|
Mouse   282 VAAFIAVLGILSIIAQT--IVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVA 344

  Fly   400 ALATIIPAANNAVASIYASPDNRGAVLGIISGIECLSEGVGPAFFGVLFFIFQDDSKN------- 457
            |:::|...|.:|:.|..|..|.:|.|.|:|:||..|..|:|||.:|.:|:||..:.|.
Mouse   345 AMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFHVELKELPITGTD 409

  Fly   458 -----------KVNSPI-SMPFVISAIGVFVAIVLTGFIKKET 488
                       :.||.| ..||:..|..|.:|:::..||.:.|
Mouse   410 LGTNTSPQHHFEQNSIIPGPPFLFGACSVLLALLVALFIPEHT 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18281	NP_649236.1	MFS	25..485	CDD:119392	160/487 (33%)
CG18281	NP_649236.1	MFS_1	30..441	CDD:284993	139/419 (33%)
Mfsd14a	NP_032272.2	MFS_MFSD14	37..449	CDD:340945	160/487 (33%)
Mfsd14a	NP_032272.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	466..490
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832363
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53596
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001490
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23504
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.810