Protein Alignment CG18281 and SLC46A1

DIOPT Version :10

• Sequence 1: NP_649236.1
• Gene: CG18281 / 40274
• FlyBaseID: FBgn0037003
• Length: 542
• Species: Drosophila melanogaster
• Sequence 2: NP_542400.2
• Gene: SLC46A1 / 113235
• HGNCID: 30521
• Length: 459
• Species: Homo sapiens
• Alignment Length: 438
• Identity: 83/438 - (18%)
• Similarity: 152/438 - (34%)
• Gaps: 94/438 - (21%)

  Fly    64 LVYGVRGIL-GFVTTPVMGAISDFHGRKVVMLLA------VATTYAPIPFMMLKSWWFF---AIL 118
            |...|.|.| |..::.::||.||..||:.:::||      .|.....:..:.|...:|.   .:.
Human    87 LYMNVGGFLVGLFSSTLLGAWSDSVGRRPLLVLASLGLLLQALVSVFVVQLQLHVGYFVLGRILC 151

  Fly   119 TVSSICGSTYSSSLAYVADTTTVENRSKGYGIVAASFGAGIAFSPSLGNYLMKSYGSASVILIAA 183
            .:....|...::|.|.|||.::..:|:....::.||.|.....:..||.:.:::.|.|:...:|.
Human   152 ALLGDFGGLLAASFASVADVSSSRSRTFRMALLEASIGVAGMLASLLGGHWLRAQGYANPFWLAL 216

  Fly   184 ITGLINIMFIIFAVPESLVLKEKNNMLDEESDNKMEDINPKERKEILNREEKLNNHVSANKSNHG 248
            ...:...::..|...|:|                      ||.|
Human   217 ALLIAMTLYAAFCFGETL----------------------KEPK--------------------- 238

  Fly   249 TSQNLVTNKELGQQFNKEENLQNDLTEKEKIDNGSLNSSDLWEVLRKSRKDKNLLVIYLITFLSI 313
             |..|.|       |....::                 ..|:......:..|:|.:..|..|:.|
Human   239 -STRLFT-------FRHHRSI-----------------VQLYVAPAPEKSRKHLALYSLAIFVVI 278

  Fly   314 WPFAGVDSTAPVY-LKTNMGFEYEEVSMMLGLLSVLA----ITSNLLLGYIINIVGAKWSIRLGL 373
            ....|......:| |.|.:.::    |.::|..|...    :||.|.|..:...:...|...:||
Human   279 TVHFGAQDILTLYELSTPLCWD----SKLIGYGSAAQHLPYLTSLLALKLLQYCLADAWVAEIGL 339

  Fly   374 LLLLLQLFFFGFGTHHWMYWLSSILAALATIIPAANNAVASIYASPDNRGAVLGIISGIECLSEG 438
            ...:|.:..|.|.|...:.:....|..|:.:|.....|..|.......:||:...::.:..|:..
Human   340 AFNILGMVVFAFATITPLMFTGYGLLFLSLVITPVIRAKLSKLVRETEQGALFSAVACVNSLAML 404

  Fly   439 VGPAFFGVLFFIFQDDSKNKVNSPISMPFVISAIGVFVAIVLTGFIKK 486
            .....|..|:       ...:|.....||::.|..:.:..||.|.::|
Human   405 TASGIFNSLY-------PATLNFMKGFPFLLGAGLLLIPAVLIGMLEK 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18281	NP_649236.1	MFS	25..485	CDD:475125	82/435 (19%)
		235kDa-fam	<203..>299	CDD:130673	8/95 (8%)
SLC46A1	NP_542400.2	MFS_SLC46A1_PCFT	22..444	CDD:341007	82/435 (19%)