DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18281 and Mfsd14a

DIOPT Version :9

Sequence 1:	NP_649236.1	Gene:	CG18281 / 40274	FlyBaseID:	FBgn0037003	Length:	542	Species:	Drosophila melanogaster
Sequence 2:	NP_001316129.1	Gene:	Mfsd14a / 103689987	RGDID:	9294064	Length:	490	Species:	Rattus norvegicus

Alignment Length:	498	Identity:	166/498 - (33%)
Similarity:	251/498 - (50%)	Gaps:	104/498 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GIGKASVWHAVIVTFMHYFSWGLLTVPFIEKLSGSFGNRVLLVDGLVYGVRGILGFVTTPVMGAI 83
            |||..||:|||||.|:.:|:|||||.|.:..|..:|.....|::||:.||:|:|.|::.|::||:
  Rat    31 GIGSPSVYHAVIVIFLEFFAWGLLTAPTLVVLHETFPKHTFLMNGLIQGVKGLLSFLSAPLIGAL 95

  Fly    84 SDFHGRKVVMLLAVATTYAPIPFMMLKSWWFFAILTVSSICGSTYSSSLAYVADTTTVENRSKGY 148
            ||..|||..:||.|..|.||||.|.:..||:||:::||.:...|:|...|||||.|....||..|
  Rat    96 SDVWGRKSFLLLTVFFTCAPIPLMKISPWWYFAVISVSGVFAVTFSVVFAYVADITQEHERSMAY 160

  Fly   149 GIVAASFGAGIAFSPSLGNYLMKSYGSASVILIAAITGLINIMFIIFAVPESLVLKEKNNMLDEE 213
            |:|:|:|.|.:..||::|.||.:.||.:.|:::|....|::|.||:.||||||
  Rat   161 GLVSATFAASLVTSPAIGAYLGRVYGDSLVVVLATAIALLDICFILVAVPESL------------ 213

  Fly   214 SDNKMEDINPKERKEILNREEKLNNHVSANKSNHGTSQNLVTNKELGQQFNKEENLQNDLTEKEK 278
                                                                          .||
  Rat   214 --------------------------------------------------------------PEK 216

  Fly   279 IDNGSLNSSDLWE------VLRKSRKDKNLLVIYLITFLSIWPFAGVDSTAPVYLKTNMGFEYEE 337
            :...|..:...||      .|:|..:|..:|:|.:..|||..|.||..|:..:||:..|.|..|.
  Rat   217 MRPASWGAPISWEQADPFASLKKVGQDSIVLLICITVFLSYLPEAGQYSSFFLYLRQIMKFSPES 281

  Fly   338 VS---MMLGLLSVLAITSNLLLGYIINIVGAKWSIRLGLLLLLLQLFFFGFGTHHWMYWLSSILA 399
            |:   .:||:||::|.|  ::|..::..:|.|.:|.|||...:|||.::|||:..||.|.:..:|
  Rat   282 VAAFIAVLGILSIIAQT--IVLSLLMRSIGNKNTILLGLGFQILQLAWYGFGSEPWMMWAAGAVA 344

  Fly   400 ALATIIPAANNAVASIYASPDNRGAVLGIISGIECLSEGVGPAFFGVLFFIFQDDSKN------- 457
            |:::|...|.:|:.|..|..|.:|.|.|:|:||..|..|:|||.:|.:|:||..:.|.
  Rat   345 AMSSITFPAVSALVSRTADADQQGVVQGMITGIRGLCNGLGPALYGFIFYIFHVELKELPITGPD 409

  Fly   458 -----------KVNSPI-SMPFVISAIGVFVAIVLTGFIKKET 488
                       :.||.| ..||:..|..|.:|:::..||.:.|
  Rat   410 LGTNTSPQHHFEQNSIIPGPPFLFGACSVLLALLVALFIPEHT 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18281	NP_649236.1	MFS	25..485	CDD:119392	160/487 (33%)
CG18281	NP_649236.1	MFS_1	30..441	CDD:284993	139/419 (33%)
Mfsd14a	NP_001316129.1	MFS	40..397	CDD:119392	147/432 (34%)
Mfsd14a	NP_001316129.1	MFS_1	42..386	CDD:284993	139/419 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336024
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53596
OrthoDB	1	1.010	-	-		D139531at33208
OrthoFinder	1	1.000	-	-		FOG0001490
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23504
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.820