DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32425 and C2CD3

DIOPT Version :9

Sequence 1:	NP_730546.1	Gene:	CG32425 / 40273	FlyBaseID:	FBgn0052425	Length:	759	Species:	Drosophila melanogaster
Sequence 2:	NP_001273506.1	Gene:	C2CD3 / 26005	HGNCID:	24564	Length:	2353	Species:	Homo sapiens

Alignment Length:	783	Identity:	155/783 - (19%)
Similarity:	278/783 - (35%)	Gaps:	209/783 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 EQTAQESEDDELVMTPELFR-----SCNALQLHLEALTLQPEGTQRMELVQNEVRP--------- 90
            :|...|:.:|...||..:.|     ..:::::.:|.:.:.|:..|.....::...|
Human   512 QQMLSETPEDAQTMTLSVDRLALLGRTHSVRIIIETMGVPPDSPQMTPGKKSYAGPPPKVTTAKK 576

  Fly    91 -IFTVECQLSGDLIRKVPRQPMFHIMQFESE----KFQSLTQCTRFGQTAQRQVDMEDKSLQD-- 148
             .|.||                :|.....||    |...:|:..|.  .:.:..|.:.|..|.
Human   577 RTFFVE----------------YHFPVGFSESGLGKTALITEVVRL--ASSKITDGKVKFQQRFV 623

  Fly   149 -PEQSAGHVDITVWW---------------REPGTCLNEMLGMGRLELRELYRASLLEQCKCIAI 197
             |.|..|.: |..||               ::|     |::|...|.||.:.::.||.....:.:
Human   624 FPVQFGGPM-IEHWWNSNLTFQIYVKKTPQKKP-----EVIGSVSLSLRAVIQSELLSFSDQLPV 682

  Fly   198 RRRDVH--LGSVYLKISLLQN----------LNG-----------SPEQ--PQQQQQQPGQKN-- 235
            ::.:..  .|.:.:.:.|:.:          |:|           ||.:  |:..|.....||
Human   683 QQENGQSPFGPLKVTMELITDNKDFTGINTKLSGNTHYTPLCAPTSPNKALPELNQDMTCTKNPQ 747

  Fly   236 -------ESGNKAAVNCNSKAVLTPPQPPAPPPPPPQANNNSKAILECINFMAETNK--VRLLRG 291
                   |:..||     ...||...:.|:|..|.|.....:.|....:|....|.|  ..||..
Human   748 NLNQIHEETAKKA-----QNLVLPNRKSPSPVAPHPSTFVATPASHNLVNQTNGTTKESALLLHV 807

  Fly   292 YLYAGELRQLTAGGSKTA--------CQELSLEPF------W-QPQPLLSKLTDGGSFELQEQFA 341
            .|...:.:...:|.|:..        |:..|.|..      | ..||:         |...:...
Human   808 LLMVPDGKDFISGESEKQSPCNVYLNCKLFSTEEVTRSVIAWGTTQPV---------FNFSQVIP 863

  Fly   342 IINDERFLQSVERQQLVME----LRPLG-----GVVRLPLHQFFIAYRDSSITNHLCKGKLPVIS 397
            :....::|:.::...:|:|    :|..|     |:|:||||||:::::|:.|:..|...:.||::
Human   864 VSLSSKYLERLKNNVMVIETWNKVRSPGQDKLLGLVKLPLHQFYMSFKDAKISRLLLDAQYPVVA 928

  Fly   398 IDGWAPIVSAENKTPLGELKVLLAIGSESQIAQLKQLRGFDHDNNQVPAPSRTTDLLDMLQNAIA 462
            :|.:.|::...:....|.|:|.||:||.:||..|::|:  :.:....|...|....||....|..
Human   929 VDSYMPVIDVFSGHQNGSLRVFLAMGSSNQIMALQRLK--NEEGTLPPFSPRPAHFLDQPTAASV 991

  Fly   463 APTPNIAGPVMPPPPAPPAPSTFSFQLRIVGAAGL-PLNPG-YGKSKKQVK-------RQSAAKR 518
            |...:....:|          ...|::.|....|| ||... :|::...|:       .||:..:
Human   992 AMAEDRGNGLM----------EHCFEIHIEMVKGLAPLQATVWGEADCYVQYYFPVQHSQSSVLK 1046

  Fly   519 FPPNEPPNTYVTFQAISCNSQTYKSHEGLVYATPIVPKSTKPQWLSKFRVDVSRDYRSNPQKLFI 583
            .|         .|.......:.:::...|....||.........|....|.|        |:|.:
Human  1047 GP---------EFLENGITLKPFRTATTLCVPDPIFNSEHHHSLLLPAEVPV--------QRLLL 1094

  Fly   584 LKLWKKAVVSPNGIT--------EPSPHEDAIIGFAALNLNQKQAGGGFP-SGWHNIVDFNGRVT 639
            .....:.:|...|:.        .|:..:            ||.|.|..| |....:|....|..
Human  1095 SAFSAQGLVPGGGVQFEIWCRYYYPNVRD------------QKVAKGTLPLSRICAMVTTQHRED 1147

  Fly   640 GGIEAHVEPISPSVDTVIDQFEKSMEL-----GHLQLGQAIKRKYTELEEISQRLRSRLVDVTGE 699
            .||:....|::|.:       |...||     |.|.:|...:|.....|.:   |.:|.|.::.:
Human  1148 VGIQTFNLPLTPRI-------ENRKELRNQSSGLLDVGLRYRRSPRTAEGV---LAARTVSISVQ 1202

  Fly   700 TLK 702
            .::
Human  1203 IIR 1205

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32425	NP_730546.1	None
C2CD3	NP_001273506.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	488..508
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..568		2/18 (11%)
		C2_C2cd3	1199..1341	CDD:176065	0/7 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1569..1591
		C2	<1679..1747	CDD:175973
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1822..1846
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1972..2032
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2084..2118
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2130..2269
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2301..2334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154596
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CMSF
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007278
OrthoInspector	1	1.000	-	-		oto90306
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5564
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.820