Protein Alignment ZnT77C and SLC30A5

DIOPT Version :9

• Sequence 1: NP_649233.2
• Gene: ZnT77C / 40271
• FlyBaseID: FBgn0037000
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_075053.2
• Gene: SLC30A5 / 64924
• HGNCID: 19089
• Length: 765
• Species: Homo sapiens
• Alignment Length: 393
• Identity: 95/393 - (24%)
• Similarity: 156/393 - (39%)
• Gaps: 83/393 - (21%)

  Fly     2 VKDILQRCKPIPLYTVLVLSICYFVLQLILSHLTHGLTLLMASHHMLCNIFALGGCIITIKHSKQ 66
            :|.||:......::..|.|::.:..::|....||:.|.|:....|||.:..||
Human   407 LKQILEESDSRQIFYFLCLNLLFTFVELFYGVLTNSLGLISDGFHMLFDCSAL------------ 459

  Fly    67 APEARNPSPALTKINGSGVAISLADTDAQTRAKRECREQKLRNTFGWARIDILTMLIVFIILASL 131
                           ..|:..:|......||.          .::|:.||:||:..|..:.|..:
Human   460 ---------------VMGLFAALMSRWKATRI----------FSYGYGRIEILSGFINGLFLIVI 499

  Fly   132 SFSLVVEALQTLVHIDHQDTMHLPIPVMMLGFIGLILNGLTYLLIGGYTL-HQGSFLHLTPGGNV 195
            :|.:.:|::..|:.....|| |:..|| .:|  |||:|     |||.... |..|..|....|:.
Human   500 AFFVFMESVARLIDPPELDT-HMLTPV-SVG--GLIVN-----LIGICAFSHAHSHAHGASQGSC 555

  Fly   196 VLERPMSSNLDLSLTPMQRHLSKSRNDRQLREELE-------TEVGSVYFATKRQGAVEMLRDVS 253
                               |.|...:...:....:       ...|....|..|...:.:|.|..
Human   556 -------------------HSSDHSHSHHMHGHSDHGHGHSHGSAGGGMNANMRGVFLHVLADTL 601

  Fly   254 STIFVIVCAAIVYVAEDEQHTAKFIDPVLSIFSCVLLVTLSYPYMKESCLILLQTIPGSIDLEI- 317
            .:|.|||...::     ||......||:.|:|..:|:.....|.:|::|.:||..:|...:.|:
Human   602 GSIGVIVSTVLI-----EQFGWFIADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKELH 661

  Fly   318 --FERTLVTKFPEIISYHDLHIWQLAAHRYVATIHIQFQNPKLYLKIIEQVRSYFHDQGIGAVTI 380
              .|:  :.|...:|||.|.|.|:.:|.....|||||..:..|..:|::||.....|.|:..:||
Human   662 IALEK--IQKIEGLISYRDPHFWRHSASIVAGTIHIQVTSDVLEQRIVQQVTGILKDAGVNNLTI 724

  Fly   381 QPE 383
            |.|
Human   725 QVE 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZnT77C	NP_649233.2	CzcD	14..384	CDD:224151	92/381 (24%)
		Cation_efflux	25..306	CDD:279834	62/288 (22%)
SLC30A5	NP_075053.2	CDF	428..729	CDD:273544	90/372 (24%)
		Cation_efflux	428..649	CDD:279834	62/290 (21%)
		His-rich loop	542..578		6/54 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	551..581		3/48 (6%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810