Protein Alignment ZnT77C and Slc30a1

DIOPT Version :9

• Sequence 1: NP_649233.2
• Gene: ZnT77C / 40271
• FlyBaseID: FBgn0037000
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_033605.1
• Gene: Slc30a1 / 22782
• MGIID: 1345281
• Length: 503
• Species: Mus musculus
• Alignment Length: 537
• Identity: 141/537 - (26%)
• Similarity: 220/537 - (40%)
• Gaps: 148/537 - (27%)

  Fly    14 LYTVLVLSICYFVLQLILSHLTHGLTLLMASHHMLCNIFALGGCIITIKHSKQAPEARNPSPALT 78
            |..:|:|:..:.||::::|.:|..|.:|..|.|||.::.||...::
Mouse    11 LLCMLLLTFMFMVLEVVVSRVTASLAMLSDSFHMLSDVLALVVALV------------------- 56

  Fly    79 KINGSGVAISLADTDAQTRAKRECREQKLRNTFGWARIDILTMLIVFIILASLSFSLVVEALQTL 143
                           |:..|:|....||  |||||.|.:::..|:..|.|..|.|::::||::..
Mouse    57 ---------------AERFARRTHATQK--NTFGWIRAEVMGALVNAIFLTGLCFAILLEAVERF 104

  Fly   144 VHIDHQDTMHLPIPVMMLGFIGLILNGLTYLLI----------GGYTLHQGSFLHLTPGG----- 193
            :. .|:  |..|:.|:.:|..||::|.|...|.          |....|.....||..|.
Mouse   105 IE-PHE--MQQPLVVLSVGVAGLLVNVLGLCLFHHHSGEGQGAGHGHSHGHGHGHLAKGARKAGR 166

  Fly   194 ------------------NVVLERPMSSNLDLSLTPMQRHLSKSRNDR----QLREELETEVGSV 236
                              |.::....:||   .|...|....|.|:|.    |:...|..|..::
Mouse   167 AGVEAGAPPGRAPDQEETNTLVANTSNSN---GLKADQAEPEKLRSDDPVDVQVNGNLIQESDNL 228

  Fly   237 YFATKRQGAVEM-------LRDVSSTIFVIVCAAIVY-----VAEDEQHT--------------- 274
            .....|.|.:.|       |.|...::.|:|.|.:.|     ..||:..|
Mouse   229 EAEDNRAGQLNMRGVFLHVLGDALGSVIVVVNALVFYFNWKGCTEDDFCTNPCFPDPCKSSVEII 293

  Fly   275 --------------AKFIDPVLSIFS-CVLLVTLSYPYMKESCLILLQTIPGSIDLEIFERTL-- 322
                          ..::||.|.|.. |:||.| :||.:|||.||||||:|..||::...:.|
Mouse   294 NSTQAPMRDAGPCWVLYLDPTLCIIMVCILLYT-TYPLLKESALILLQTVPKQIDIKHLVKELRD 357

  Fly   323 VTKFPEIISYHDLHIWQLAAHRYVATIHIQFQNPKLYLKIIEQVRSYFHDQGIGAVTIQPEFYPS 387
            |....|:   |:||:||||..|.:||.||:.::|..|:::.:.::..||:.||.|.||||||...
Mouse   358 VDGVEEV---HELHVWQLAGSRIIATAHIKCEDPASYMQVAKTIKDVFHNHGIHATTIQPEFASV 419

  Fly   388 TNKNASASLECLMQCQAVECIEKVCCRDSRTDLREVCDAPSGRKSSSPVKCAGNSHEHSRAKSKS 452
            .:|  |:.|.|.:.|: .:|..|.||                  .:.|...:|...|.:...|.|
Mouse   420 GSK--SSVLPCELACR-TQCALKQCC------------------GTRPQVHSGKDAEKAPTVSIS 463

  Fly   453 CAELSAVVVEKPEELSA 469
            |.|||..:.:|.....|
Mouse   464 CLELSENLEKKARRTKA 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZnT77C	NP_649233.2	CzcD	14..384	CDD:224151	119/450 (26%)
		Cation_efflux	25..306	CDD:279834	83/359 (23%)
Slc30a1	NP_033605.1	CzcD	6..418	CDD:224151	121/452 (27%)
		Cation_efflux	21..339	CDD:279834	83/360 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	140..213		13/75 (17%)
		6 X 2 AA approximate repeats of H-G	145..156		2/10 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8321
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2701
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45820
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.820