Protein Alignment ZnT77C and Slc30a10

DIOPT Version :9

• Sequence 1: NP_649233.2
• Gene: ZnT77C / 40271
• FlyBaseID: FBgn0037000
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_001028458.1
• Gene: Slc30a10 / 226781
• MGIID: 2685058
• Length: 470
• Species: Mus musculus
• Alignment Length: 529
• Identity: 131/529 - (24%)
• Similarity: 210/529 - (39%)
• Gaps: 132/529 - (24%)

  Fly    10 KPIPLYTVLVLSICYFVLQLILSHLTHGLTLLMASHHMLCNIFALGGCIITIKHSKQAPEARNPS 74
            |...|..:|||:..:||.:|:..:|.:.:.||..|.:||.::.:|  |:..
Mouse     7 KTCRLLFMLVLTAAFFVAELVSGYLGNSIALLSDSFNMLSDLISL--CVGL-------------- 55

  Fly    75 PALTKINGSGVAISLADTDAQTRAKRECREQKLRNTFGWARIDILTMLIVFIILASLSFSLVVEA 139
                   |||..           |:|..|....  |:|:.|.:::..|...:.|.:|.|::.|||
Mouse    56 -------GSGYI-----------ARRGPRGSSA--TYGYVRAEVVGALSNAVFLTALCFTIFVEA 100

  Fly   140 LQTLVHIDHQDTMHLPIPVMMLGFIGLILNGLTYLLI---------------------------- 176
            :..|...:..|...|   |:::|.:||.:|.:..|:.
Mouse   101 VLRLARPERIDDPEL---VLIVGALGLAVNVVGLLIFQDCGACFSRCTRGRRTRPSQQPSQGDPR 162

  Fly   177 GGYTLHQGSFLHLTPG-GNVVLERPMSS--NLDLSLTPMQRHLSKSRNDRQLREELETEVGSVYF 238
            |.....|.:.....|| |..|..|..|:  ......|........|.|.....||
Mouse   163 GALGCPQEAATATAPGSGTAVTLRGSSAGRKQQEGATVFSNVAGDSLNTENEPEE---------- 217

  Fly   239 ATKRQGAVEMLR----------DVSSTIFVIVCAAIVYV----AEDEQHTAKFIDPVLSIFSCVL 289
            .||::...|.|.          |...::.|::.|.|.||    .||..:...:|||.|::...::
Mouse   218 TTKKEKKSEALNIRGVLLHVMGDALGSVVVVITAIIFYVQPLRREDPCNWQCYIDPSLTVVMVII 282

  Fly   290 LVTLSYPYMKESCLILLQTIPGSIDLEIFERTLVTKFPEIISYHDLHIWQLAAHRYVATIHIQFQ 354
            :::.::|.:||:.:||||.:|..:::|.....|.| .|.|.|.|::|||:|.:.:.:||:||:.|
Mouse   283 ILSSAFPLIKETAVILLQMVPKGVNMEELMSQLST-VPGISSVHEVHIWELISGKIIATLHIKHQ 346

  Fly   355 NPKLYLKIIEQVRSYFHDQGIGAVTIQPEFYPSTNKNASASLECLMQCQA----VECIEKVCCRD 415
            ....|.....::|..||..||..||||  |.....|.|....:.|:.|.|    ..|.:|:||
Mouse   347 KGTEYQDASRKIREIFHHAGIHNVTIQ--FETLDLKEALEQKDFLLTCSAPCITQSCAKKLCC-- 407

  Fly   416 SRTDLREVCDAPSGRKSSSPVK-CAGNSHEHSRAKSKSCAELSAVVVEKPE--------ELSAGQ 471
                       |.|....:.|. ||.::...||...:|        :|.||        ....||
Mouse   408 -----------PPGTLPLALVNGCAEHNGRSSRESYRS--------IEAPEVAIDVDGCPREQGQ 453

  Fly   472 LL-KGQDQQ 479
            .| |.|::|
Mouse   454 TLSKTQERQ 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZnT77C	NP_649233.2	CzcD	14..384	CDD:224151	103/414 (25%)
		Cation_efflux	25..306	CDD:279834	69/325 (21%)
Slc30a10	NP_001028458.1	CzcD	10..376	CDD:224151	104/417 (25%)
		Cation_efflux	20..299	CDD:279834	69/327 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	146..223		15/86 (17%)
		Required for plasma membrane localization. /evidence=ECO:0000250|UniProtKB:Q6XR72	300..470		55/187 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	451..470		6/12 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D458019at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45820
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920