DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZnT77C and SLC30A8

DIOPT Version :9

Sequence 1:	NP_649233.2	Gene:	ZnT77C / 40271	FlyBaseID:	FBgn0037000	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_776250.2	Gene:	SLC30A8 / 169026	HGNCID:	20303	Length:	369	Species:	Homo sapiens

Alignment Length:	333	Identity:	59/333 - (17%)
Similarity:	129/333 - (38%)	Gaps:	94/333 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SIC--YFVLQLILSHLTHGLTLLMASHHMLCNIFALGGCIITIKHSKQAPEARNPSPALTKINGS 83
            :||  :.:.:::..|:...|.::..:.|:|.::.:....:.::..|.:.|..
Human    79 AICFIFMIAEVVGGHIAGSLAVVTDAAHLLIDLTSFLLSLFSLWLSSKPPSK------------- 130

  Fly    84 GVAISLADTDAQTRAKRECREQKLRNTFGWARIDILTMLIVFIILASLSFSLVVEALQTLVHIDH 148
                                    |.||||.|.:||..|:..:.:..::..||..|.:.|::.|:
Human   131 ------------------------RLTFGWHRAEILGALLSILCIWVVTGVLVYLACERLLYPDY 171

  Fly   149 QDTMHLPIPVMMLGFIGLILNGLTYLLIGGYTLHQGSFLHLTPGGNVVLERPMSSNLDLSLTPMQ 213
            |    :...||:                                  :|....:::|:.|::...|
Human   172 Q----IQATVMI----------------------------------IVSSCAVAANIVLTVVLHQ 198

  Fly   214 RHLSKSRNDRQLREELETEVGSVYFATKRQGAVEMLRDVSSTIFVIVCAAIVYVAEDEQHTAKFI 278
            |.|..:..:.|..            |:.|...|..|.|:..:|.|::.|.|:|...:    .|..
Human   199 RCLGHNHKEVQAN------------ASVRAAFVHALGDLFQSISVLISALIIYFKPE----YKIA 247

  Fly   279 DPVLSIFSCVLLVTLSYPYMKESCLILLQTIPGSIDLEIFERTLVTKFPEIISYHDLHIWQLAAH 343
            ||:.:....:|::..:...:|:..::|::.:|.|::.. ..:.|:.....::|.|.||||.|..:
Human   248 DPICTFIFSILVLASTITILKDFSILLMEGVPKSLNYS-GVKELILAVDGVLSVHSLHIWSLTMN 311

  Fly   344 RYVATIHI 351
            :.:.:.|:
Human   312 QVILSAHV 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZnT77C	NP_649233.2	CzcD	14..384	CDD:224151	59/333 (18%)
ZnT77C	NP_649233.2	Cation_efflux	25..306	CDD:279834	45/280 (16%)
SLC30A8	NP_776250.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..52
		CDF	83..353	CDD:273544	57/329 (17%)
		Cation_efflux	83..274	CDD:279834	45/281 (16%)
		HXXXXX[HY]NH-motif	197..205		3/7 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D820567at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820