Protein Alignment ZnT77C and SLC30A8

DIOPT Version :10

• Sequence 1: NP_649233.2
• Gene: ZnT77C / 40271
• FlyBaseID: FBgn0037000
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_776250.2
• Gene: SLC30A8 / 169026
• HGNCID: 20303
• Length: 369
• Species: Homo sapiens
• Alignment Length: 333
• Identity: 59/333 - (17%)
• Similarity: 129/333 - (38%)
• Gaps: 94/333 - (28%)

  Fly    21 SIC--YFVLQLILSHLTHGLTLLMASHHMLCNIFALGGCIITIKHSKQAPEARNPSPALTKINGS 83
            :||  :.:.:::..|:...|.::..:.|:|.::.:....:.::..|.:.|..
Human    79 AICFIFMIAEVVGGHIAGSLAVVTDAAHLLIDLTSFLLSLFSLWLSSKPPSK------------- 130

  Fly    84 GVAISLADTDAQTRAKRECREQKLRNTFGWARIDILTMLIVFIILASLSFSLVVEALQTLVHIDH 148
                                    |.||||.|.:||..|:..:.:..::..||..|.:.|::.|:
Human   131 ------------------------RLTFGWHRAEILGALLSILCIWVVTGVLVYLACERLLYPDY 171

  Fly   149 QDTMHLPIPVMMLGFIGLILNGLTYLLIGGYTLHQGSFLHLTPGGNVVLERPMSSNLDLSLTPMQ 213
            |    :...||:                                  :|....:::|:.|::...|
Human   172 Q----IQATVMI----------------------------------IVSSCAVAANIVLTVVLHQ 198

  Fly   214 RHLSKSRNDRQLREELETEVGSVYFATKRQGAVEMLRDVSSTIFVIVCAAIVYVAEDEQHTAKFI 278
            |.|..:..:.|..            |:.|...|..|.|:..:|.|::.|.|:|...:    .|..
Human   199 RCLGHNHKEVQAN------------ASVRAAFVHALGDLFQSISVLISALIIYFKPE----YKIA 247

  Fly   279 DPVLSIFSCVLLVTLSYPYMKESCLILLQTIPGSIDLEIFERTLVTKFPEIISYHDLHIWQLAAH 343
            ||:.:....:|::..:...:|:..::|::.:|.|::.. ..:.|:.....::|.|.||||.|..:
Human   248 DPICTFIFSILVLASTITILKDFSILLMEGVPKSLNYS-GVKELILAVDGVLSVHSLHIWSLTMN 311

  Fly   344 RYVATIHI 351
            :.:.:.|:
Human   312 QVILSAHV 319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZnT77C	NP_649233.2	CzcD	14..383	CDD:440843	59/333 (18%)
SLC30A8	NP_776250.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	31..52
		CzcD	50..358	CDD:440843	59/333 (18%)
		HCH Motif, seals regulatory zinc-binding pocket. /evidence=ECO:0000269|PubMed:32723473	52..54