Protein Alignment ZnT77C and SLC30A7

DIOPT Version :9

• Sequence 1: NP_649233.2
• Gene: ZnT77C / 40271
• FlyBaseID: FBgn0037000
• Length: 513
• Species: Drosophila melanogaster
• Sequence 2: NP_001138356.1
• Gene: SLC30A7 / 148867
• HGNCID: 19306
• Length: 376
• Species: Homo sapiens
• Alignment Length: 413
• Identity: 82/413 - (19%)
• Similarity: 153/413 - (37%)
• Gaps: 119/413 - (28%)

  Fly    14 LYTVLVLSICYFVLQLILSHLTHGLTLLMASHHMLCNIFALGGCIITIKHSKQAPEARNPSPALT 78
            |:..|.|::.:..::|:....::.|.|:..|.||..:                       |.|:.
Human    38 LFFFLCLNLSFAFVELLYGIWSNCLGLISDSFHMFFD-----------------------STAIL 79

  Fly    79 KINGSGVAISL----ADTDAQTRAKRECREQKLRNTFGWARIDILTMLI--VFIIL-ASLSFSLV 136
                :|:|.|:    .|.||              .::|:.|.::|...:  :|:|. |...||..
Human    80 ----AGLAASVISKWRDNDA--------------FSYGYVRAEVLAGFVNGLFLIFTAFFIFSEG 126

  Fly   137 VEALQTLVHIDHQDTMHLPIPVMMLGFIGLILNGLTYLLIGGYTLHQGSFLHLTPGG-------- 193
            ||.......:.|:       .::::..:|.::|     |||.:....|...|....|
Human   127 VERALAPPDVHHE-------RLLLVSILGFVVN-----LIGIFVFKHGGHGHSHGSGHGHSHSLF 179

  Fly   194 NVVLERPMSSNLDLSLTPMQRHLSKSRNDR-------------QLREELETEVGSVYFATKR--- 242
            |..|:: ...::|...:...:|.:...:|.             .|:|..         ...|
Human   180 NGALDQ-AHGHVDHCHSHEVKHGAAHSHDHAHGHGHFHSHDGPSLKETT---------GPSRQIL 234

  Fly   243 QGA-VEMLRDVSSTIFVIVCAAIVYVAEDEQHTAKFIDPVLSIFSCVLLVTLSYPYMKESCLILL 306
            ||. :.:|.|...:|.||..|.::     :.......||:.||...:|:|....|.::||..||:
Human   235 QGVFLHILADTLGSIGVIASAIMM-----QNFGLMIADPICSILIAILIVVSVIPLLRESVGILM 294

  Fly   307 QTIPGSIDLEI---FERTLVTKFPEIISYHDLHIWQLAAHRYVATIHIQFQNPKLYLK------- 361
            |..|..::..:   ::|  |.:...:.|..:.|.|.|.:..||.|:       ||.:.
Human   295 QRTPPLLENSLPQCYQR--VQQLQGVYSLQEQHFWTLCSDVYVGTL-------KLIVAPDADARW 350

  Fly   362 IIEQVRSYFHDQGIGAVTIQPEF 384
            |:.|..:.|...|:..:.:|.:|
Human   351 ILSQTHNIFTQAGVRQLYVQIDF 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZnT77C	NP_649233.2	CzcD	14..384	CDD:224151	81/411 (20%)
		Cation_efflux	25..306	CDD:279834	59/312 (19%)
SLC30A7	NP_001138356.1	CzcD	31..374	CDD:224151	82/413 (20%)
		Cation_efflux	48..294	CDD:279834	59/313 (19%)
		His-rich loop	161..218		8/57 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..226		3/31 (10%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1230
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810