DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment isoQC and Qpctl

DIOPT Version :9

Sequence 1:	NP_788550.1	Gene:	isoQC / 40270	FlyBaseID:	FBgn0036999	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_080387.2	Gene:	Qpctl / 67369	MGIID:	1914619	Length:	383	Species:	Mus musculus

Alignment Length:	384	Identity:	157/384 - (40%)
Similarity:	220/384 - (57%)	Gaps:	50/384 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RLLLRNYSLME----AVKRLLPRPR-----KKIYNLGACFELVDIPKISYNP--SELSEPRFLE- 54
            |..|.:..||:    :.:|||||.:     .....:|..|.:|   ..|::|  .|:|..|.|.
Mouse    10 RQRLEDRGLMKPPSLSKRRLLPRVQFLPLLLLALAMGLAFYIV---WNSWHPGVEEMSRSRDLRV 71

  Fly    55 --YSNLSD-KLHL-----------REAIDKILIPRVVGTTNHSIVREYIVQSLRDLD--WDVEVN 103
              ..:||: ||.|           ...:..:||.|..|::.:..||:::..:|:.|.  |.||::
Mouse    72 PLIGSLSEAKLRLVVGQLDPQRLWGTFLRPLLIVRPPGSSGNLQVRKFLEATLQSLSAGWHVELD 136

  Fly   104 SFHDHAPIKGKLHFHNIIATLNPNAERYLVLSCHYDSKYM-PGV-EFLGATDSAVPCAMLLNLAQ 166
            .|....|: |.|.|.|::|||:|.|.|:|.|:||||||:. ||: .|:||||||||||:||.|.|
Mouse   137 PFTASTPL-GPLDFGNVVATLDPGAARHLTLACHYDSKFFPPGLPPFVGATDSAVPCALLLELVQ 200

  Fly   167 VLQEQLKPLKK--SKLSLMLLFFDGEEAFEEWGPKDSIYGARHLAKKW----HHEG--KLDRIDM 223
            .|...|..:|:  :.::|.|||.|||||.:|||||||:||:||||:..    |..|  ::..|::
Mouse   201 ALDAMLSRIKQQAAPVTLQLLFLDGEEALKEWGPKDSLYGSRHLAQIMESIPHSPGPTRIQAIEL 265

  Fly   224 LVLLDLLGAPDPAFYSFFENTESWYMRIQSVETRLAKLQLLERYASSGVAQRDPTRYFQSQAMRS 288
            .||||||||..|.|:|.|..|..|:.|::|:|.||.:|.||:.:...       ..|||......
Mouse   266 FVLLDLLGASSPIFFSHFPRTARWFQRLRSIEKRLHRLNLLQSHPQE-------VMYFQPGEPPG 323

  Fly   289 SFIEDDHIPFLRRNVPILHLIPVPFPSVWHTPDDNASVIDYATTDNLALIIRLFALEYL 347
            . :||||||||||.||:||||..|||:|||||.|..:.:...|..||:.|:.:|..|||
Mouse   324 P-VEDDHIPFLRRGVPVLHLIATPFPAVWHTPADTEANLHPPTVHNLSRILAVFLAEYL 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
isoQC	NP_788550.1	M28_QC_like	56..346	CDD:193501	136/313 (43%)
Qpctl	NP_080387.2	M28_QC_like	80..380	CDD:193501	134/308 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2442
eggNOG	1	0.900	-	-		E1_KOG3946
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	257	1.000	Inparanoid score	I3132
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55920
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001509
OrthoInspector	1	1.000	-	-		mtm8891
orthoMCL	1	0.900	-	-		OOG6_102560
Panther	1	1.100	-	-	LDO	PTHR12283
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2349
SonicParanoid	1	1.000	-	-		X1074
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.860