DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment isoQC and QPCTL

DIOPT Version :9

Sequence 1:	NP_788550.1	Gene:	isoQC / 40270	FlyBaseID:	FBgn0036999	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_060129.2	Gene:	QPCTL / 54814	HGNCID:	25952	Length:	382	Species:	Homo sapiens

Alignment Length:	384	Identity:	159/384 - (41%)
Similarity:	212/384 - (55%)	Gaps:	51/384 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RLLLRNYSLMEAV----KRLLPR----PRKKIYNLGACF------------EL-----VDIPKIS 41
            ||.|....|||.:    :|||||    |......:|:.|            ||     :.:|.|
Human    10 RLRLGERGLMEPLLPPKRRLLPRVRLLPLLLALAVGSAFYTIWSGWHRRTEELPLGRELRVPLI- 73

  Fly    42 YNPSELSEPRFLEYSNLSDKLHLREA-IDKILIPRVVGTTNHSIVREYIVQSLRDL--DWDVEVN 103
               ..|.|.|........|...|... :..:|:.|..|:..:..||:::..:||.|  .|.||::
Human    74 ---GSLPEARLRRVVGQLDPQRLWSTYLRPLLVVRTPGSPGNLQVRKFLEATLRSLTAGWHVELD 135

  Fly   104 SFHDHAPIKGKLHFHNIIATLNPNAERYLVLSCHYDSKYMP--GVEFLGATDSAVPCAMLLNLAQ 166
            .|....|: |.:.|.|::|||:|.|.|:|.|:||||||..|  ...|:||||||||||:||.|||
Human   136 PFTASTPL-GPVDFGNVVATLDPRAARHLTLACHYDSKLFPPGSTPFVGATDSAVPCALLLELAQ 199

  Fly   167 VLQEQLKPLKK--SKLSLMLLFFDGEEAFEEWGPKDSIYGARHLAKKW----HHEG--KLDRIDM 223
            .|..:|...||  :.::|.|||.|||||.:|||||||:||:||||:..    |..|  ::..|::
Human   200 ALDLELSRAKKQAAPVTLQLLFLDGEEALKEWGPKDSLYGSRHLAQLMESIPHSPGPTRIQAIEL 264

  Fly   224 LVLLDLLGAPDPAFYSFFENTESWYMRIQSVETRLAKLQLLERYASSGVAQRDPTRYFQSQAMRS 288
            .:||||||||:|.|||.|..|..|:.|::|:|.||.:|.||:.:...       ..|||......
Human   265 FMLLDLLGAPNPTFYSHFPRTVRWFHRLRSIEKRLHRLNLLQSHPQE-------VMYFQPGEPFG 322

  Fly   289 SFIEDDHIPFLRRNVPILHLIPVPFPSVWHTPDDNASVIDYATTDNLALIIRLFALEYL 347
            | :||||||||||.||:||||..|||:|||||.|....:...|..||..|:.:|..|||
Human   323 S-VEDDHIPFLRRGVPVLHLISTPFPAVWHTPADTEVNLHPPTVHNLCRILAVFLAEYL 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
isoQC	NP_788550.1	M28_QC_like	56..346	CDD:193501	135/302 (45%)
QPCTL	NP_060129.2	M28_QC_like	79..379	CDD:193501	136/308 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	235	1.000	Domainoid score	I2376
eggNOG	1	0.900	-	-		E1_KOG3946
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	263	1.000	Inparanoid score	I3088
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55920
OrthoDB	1	1.010	-	-		D1257754at2759
OrthoFinder	1	1.000	-	-		FOG0001509
OrthoInspector	1	1.000	-	-		mtm8656
orthoMCL	1	0.900	-	-		OOG6_102560
Panther	1	1.100	-	-	LDO	PTHR12283
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2349
SonicParanoid	1	1.000	-	-		X1074
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870