DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment isoQC and Qpctl

DIOPT Version :9

Sequence 1:	NP_788550.1	Gene:	isoQC / 40270	FlyBaseID:	FBgn0036999	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_001099700.1	Gene:	Qpctl / 292687	RGDID:	1308128	Length:	383	Species:	Rattus norvegicus

Alignment Length:	380	Identity:	159/380 - (41%)
Similarity:	221/380 - (58%)	Gaps:	48/380 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RLLLRNYSLMEAVKRLLPRPR-----KKIYNLGACFELVDIPKISYNP--SELSEPRFLE---YS 56
            |.|::..||.:  :|||||.:     .....||..|.:|   ..|::|  .|:|..|.|.   ..
  Rat    16 RGLMKPPSLSK--RRLLPRVQLLPLLLLALALGLAFYIV---WNSWHPGVEEVSRSRDLRVPLIG 75

  Fly    57 NLSD-KLHL-----------REAIDKILIPRVVGTTNHSIVREYIVQSLRDLD--WDVEVNSFHD 107
            :||: ||.|           ...:..:||.|..|:..:..||:::..:|:.|.  |.||::.|..
  Rat    76 SLSEAKLRLVVGQLDPQRLWGTFLRPLLIVRPPGSPGNLQVRKFLEATLQSLSAGWHVELDPFTA 140

  Fly   108 HAPIKGKLHFHNIIATLNPNAERYLVLSCHYDSKYM-PGV-EFLGATDSAVPCAMLLNLAQVLQE 170
            ..|: |.|.|.|::|||:|.|.|:|.|:||||||:. ||: .|:||||||||||:||.|.|.|..
  Rat   141 STPL-GPLDFGNVVATLDPGAARHLTLACHYDSKFFPPGLPPFVGATDSAVPCALLLELVQALDV 204

  Fly   171 QLKPLKK--SKLSLMLLFFDGEEAFEEWGPKDSIYGARHLAKKW----HHEG--KLDRIDMLVLL 227
            .|..:|:  :.::|.|||.|||||.:|||||||:||:||||:..    |..|  ::..|::.|||
  Rat   205 MLSRIKQQAAPVTLQLLFLDGEEALKEWGPKDSLYGSRHLAQIMESIPHSPGPTRIQAIELFVLL 269

  Fly   228 DLLGAPDPAFYSFFENTESWYMRIQSVETRLAKLQLLERYASSGVAQRDPTRYFQSQAMRSSFIE 292
            ||||||.|.|:|.|..|..|:.|::|:|.||.:|.||:.:...       ..|||....... :|
  Rat   270 DLLGAPSPIFFSHFPRTARWFQRLRSIEKRLHRLNLLQSHPQE-------VMYFQPGEPPGP-VE 326

  Fly   293 DDHIPFLRRNVPILHLIPVPFPSVWHTPDDNASVIDYATTDNLALIIRLFALEYL 347
            |||||||||.||:||||.:|||:|||||.|..:.:...|..||:.|:.:|..|||
  Rat   327 DDHIPFLRRGVPVLHLIAMPFPAVWHTPADTEANLHPPTVHNLSRILAVFLAEYL 381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
isoQC	NP_788550.1	M28_QC_like	56..346	CDD:193501	137/313 (44%)
Qpctl	NP_001099700.1	M28_QC_like	80..380	CDD:193501	135/308 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	229	1.000	Domainoid score	I2392
eggNOG	1	0.900	-	-		E1_KOG3946
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	256	1.000	Inparanoid score	I3082
OMA	1	1.010	-	-		QHG55920
OrthoDB	1	1.010	-	-		D1257754at2759
OrthoFinder	1	1.000	-	-		FOG0001509
OrthoInspector	1	1.000	-	-		mtm9135
orthoMCL	1	0.900	-	-		OOG6_102560
Panther	1	1.100	-	-	LDO	PTHR12283
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1074
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840