DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment isoQC and QPCT

DIOPT Version :9

Sequence 1:	NP_788550.1	Gene:	isoQC / 40270	FlyBaseID:	FBgn0036999	Length:	354	Species:	Drosophila melanogaster
Sequence 2:	NP_036545.1	Gene:	QPCT / 25797	HGNCID:	9753	Length:	361	Species:	Homo sapiens

Alignment Length:	370	Identity:	161/370 - (43%)
Similarity:	222/370 - (60%)	Gaps:	46/370 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRLLLRNYSLMEAVKRLLPR----PRKKIYNLGACFELVDIPKISYNPSELSEPRFLEYSNLSDK 61
            :.|||...:|..|.:.:.|.    |.:|.|:..|..          |.|.|.:  ..|.:::|:.
Human    13 LHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAIL----------NSSALRQ--IAEGTSISEM 65

  Fly    62 LHLREAIDKILIPRVVGTTNHSIVREYIVQSLRDL--DWDVEVNSFHDHAPIKGKLHFHNIIATL 124
              .:..:..:||.|..|:......|::|:|.::.|  ||.:|:::|....|. |...|.|||:||
Human    66 --WQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPY-GYRSFSNIISTL 127

  Fly   125 NPNAERYLVLSCHYDSKYMP---GVEFLGATDSAVPCAMLLNLAQVLQEQLKPLK-----KSKLS 181
            ||.|:|:|||:|||||||..   ...|:|||||||||||:|.||:.|.::|..||     |..||
Human   128 NPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLS 192

  Fly   182 LMLLFFDGEEAFEEWGPKDSIYGARHLAKKW----HHEG-----KLDRIDMLVLLDLLGAPDPAF 237
            |.|:||||||||..|.|:||:||:||||.|.    |..|     :|..:|:||||||:|||:|.|
Human   193 LQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTF 257

  Fly   238 YSFFENTESWYMRIQSVETRLAKLQLLERYASSGVAQRDPTRYFQSQAMRSSFIEDDHIPFLRRN 302
            .:||.|:..|:.|:|::|..|.:|.||:.::..|       ||||:.:. ...|:|||||||||.
Human   258 PNFFPNSARWFERLQAIEHELHELGLLKDHSLEG-------RYFQNYSY-GGVIQDDHIPFLRRG 314

  Fly   303 VPILHLIPVPFPSVWHTPDDNASVIDYATTDNLALIIRLFALEYL 347
            ||:|||||.|||.||||.|||...:|.:|.|||..|:::|.||||
Human   315 VPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYL 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
isoQC	NP_788550.1	M28_QC_like	56..346	CDD:193501	144/308 (47%)
QPCT	NP_036545.1	M28_QC_like	51..358	CDD:193501	147/319 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	235	1.000	Domainoid score	I2376
eggNOG	1	0.900	-	-		E1_KOG3946
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8238
Inparanoid	1	1.050	263	1.000	Inparanoid score	I3088
Isobase	1	0.950	-	0.861353	Normalized mean entropy	S1680
OMA	1	1.010	-	-		QHG55920
OrthoDB	1	1.010	-	-		D1257754at2759
OrthoFinder	1	1.000	-	-		FOG0001509
OrthoInspector	1	1.000	-	-		mtm8656
orthoMCL	1	0.900	-	-		OOG6_102560
Panther	1	1.100	-	-	O	PTHR12283
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2349
SonicParanoid	1	1.000	-	-		X1074
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820